Open reading frame – Page 6 – Communicable Diseases Research

1 H, 13 C, and 15 N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein)

Article

Published on 2021-03-262022-10-27
Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS,

Risk stratification by long non‐coding RNAs profiling in COVID‐19 patients

COVID-19 환자의 긴 비코딩 RNA 프로파일링에 의한 위험 계층화

Original Article

Published on 2021-03-232022-09-10
Journal: Journal of Cellular and Molecular Medicine [Category] 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Analysis caused coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 disease enrolled Frame function functions global pandemic Health healthy control healthy controls heterogeneous immune individuals information lack lncRNA Long mononuclear cell mononuclear cells nucleotide nucleotides Open reading frame operator Patient Peripheral blood Peripheral blood mononuclear cells pulmonary injury reported respiratory risk RNA RNA sequencing RNA‐seq SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus Stratification subclass subtype Transcriptome valuable resource
[DOI] 10.1111/jcmm.16444 PMC 바로가기 [Article Type] Original Article

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

SARS-CoV-2에서 G-quadruplex 형성 시퀀스의 발견

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 진단, 치료법,

T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals

T 세포 및 항체 동역학은 COVID-19 회복기 개인에서 장기 면역 반응을 매개하는 SARS-CoV-2 펩티드를 묘사합니다

Research Article

Published on 2021-03-152022-09-10
Journal: Science Translational Medicine [Category] MERS, SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody kinetics Antibody titer Antibody titers approaches Cell convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine design dominant Efficacy epitope Epitopes Frequency functional Humoral immunity identification identify Immunity Immunological memory intensity investigated long-term immune response longitudinal longitudinal analysis memory T memory T cell nucleocapsid nucleocapsid-specific antibody open Open reading frame peptide Post-infection question remained report respiratory response responses robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 peptide severe acute respiratory syndrome Coronavirus spike T cell T cell epitope T cell memory T cell response T cell responses target vaccination
[DOI] 10.1126/scitranslmed.abf7517 PMC 바로가기 [Article Type] Research Article

Risks associated with cryopreserved semen in a human sperm bank during and after the COVID-19 pandemic

COVID-19 대유행 기간 동안 및 이후에 인간 정자 은행의 냉동보존된 정액과 관련된 위험

Comment

Published on 2021-03-012022-09-11
Journal: Reproductive biomedicine online [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제,

[키워드] Bank Blood blood sample Blood samples Chain Reaction China cohort study collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic crystal Crystal digital PCR detect digital PCR Donor droplet external use false-negative false-negative results Frame Genes Human Human sperm bank men nucleocapsid protein Open reading frame OSN-qRT-PCR pandemic polymerase chain polymerase chain reaction positive Quantitative retrospective cohort study risk RNA Safe SARS-CoV-2 Semen semen sample Semen samples specimen Sperm sperm bank Target genes tested two group was performed was used Wave Wuhan
[DOI] 10.1016/j.rbmo.2020.11.015 PMC 바로가기 [Article Type] Comment

Evaluation of sample pooling for screening of SARS CoV-2

SARS CoV-2 스크리닝을 위한 샘플 풀링 평가

Research Article

Published on 2021-02-262022-09-10
Journal: PLoS ONE [Category] MERS, 진단, 치료기술, 치료법, 치료제,

[키워드] Accuracy ad hoc Algorithm amplified approach approaches Chain Reaction clinical sample clinical samples Community coronavirus disease Coronavirus disease 2019 COVID-19 cycle threshold diagnostic diagnostic testing Disease prevalence Efficiency equipment evaluated expansion expected extracted RNA false negativity Final Frame genomic region global public health greater increase in indicated Mass screening nucleic acid nucleocapsid objective Open reading frame ORF1 ORF1ab overcome pandemic polymerase chain polymerase chain reaction pooling positive positive sample Predictive protocol reaction reagent reagents Result reverse transcriptase robust RT-PCR RT-PCR assay Sample size SARS CoV SARS CoV-2 SARS-CoV-2 tested transcriptase Viral virus Volume
[DOI] 10.1371/journal.pone.0247767 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation

Article

Published on 2021-02-262022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] activate Activation activation of inflammasome amino acid residue antagonist antiviral immune response caspase-1 cDNA cells complementary complexes coronavirus disease Coronaviruses detrimental effect DNA domain dysregulated Effect Effector mechanism evade Helicase Host IL-1β implicated induce Inflammasome inflammasome activation inhibit inhibited involved MERS-CoV NLRP3 NLRP3 inflammasome nonstructural protein nsp1 Open reading frame ORFs Pathogenesis positive promote reduced Replication responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 NSP1 Screening secretion severe acute respiratory syndrome coronavirus 2 severity significantly THP-1 translation viral clearance viral replication virus
[DOI] 10.3390/microorganisms9030494 PMC 바로가기 [Article Type] Article

Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France

일상적인 게놈 감시 동안 병원 클러스터에서 검출된 SARS-CoV-2 ORF6 결실 변이체의 특성화, 프랑스 리옹

Coronaviruses

Published on 2021-01-272022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종, 치료기술,

[키워드] Analysis Care CCL2 center characterization Cluster coding collected comparable replication Cytokines Deletion deletion variant disease severity fecal Frame France genomic Genomic surveillance Health Health care high plasma level high plasma levels hospital Host immune response host immune responses immune responses Infection Inflammation Inflammatory cytokine Inflammatory cytokines interferon-stimulated gene interferon-stimulated genes MCP1 molecular MONITOR nasopharyngeal sample NF-kB NF-kB pathway no difference nosocomial nosocomial cluster Nosocomial transmission Occurrence one health Open reading frame ORF6 overexpression Patient patients hospitalized performed Ptx3 reference respiratory respiratory viruses SARS-CoV-2 sequence severe COVID-19 Stool suggested Surveillance TNFα Transmission upregulated variants viruses while wild-type
[DOI] 10.1080/22221751.2021.1872351 PMC 바로가기 [Article Type] Coronaviruses

SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike

SARS-CoV-2 감염 심각도는 스파이크에 대한 우수한 체액 면역과 관련이 있습니다.

Research Article

Published on 2021-01-192022-09-10
Journal: mBio [Category] 변종, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response antibody response against Antigen binding Cell coronavirus COVID-19 COVID-19 disease Critical cross-react D614G epitope Frame global pandemic greater Humoral immunity Infection infection severity memory B memory B cell memory B cells mounted mutant natural immunity Neutralizing antibodies Neutralizing antibody response nonstructural proteins nucleocapsid protein Open reading frame pandemic Receptor binding domain respiratory reveal robust SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease severe SARS-CoV-2 specificity Spike protein subject Superior the antibody response the Spike Viral viral antigens virus
[DOI] 10.1128/mBio.02940-20 PMC 바로가기 [Article Type] Research Article

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

여러 세포 모델 및 임상 샘플에서 SARS-CoV-2에 대한 호스트 미토콘드리아 전사체 반응

Article

Published on 2021-01-082022-09-10
Journal: Scientific Reports [Category] 유전자 메커니즘,