Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variantSARS-CoV-2 스파이크에서 우성 및 하위 우성 에피토프를 인식하는 단일클론 항체의 중화 효능은 B.1.1.7 변이체의 영향을 받습니다.Article Published on 2021-06-082022-09-10 Journal: Immunity [Category] MERS, SARS, 변종, 진단, [키워드] Abstract Affect antibodies antibody antigenic antigenic drift antigenicity arising Asymptomatic B.1.1.7 B.1.1.7 variant characterized circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants COVID-19 disease COVID-19 disease severity disease severity dominant Donor epitope Epitopes glycan host cell host cells Immune escape impacted individual infected individuals Infectious virus less monoclonal antibodies monoclonal antibody MOST Mutation N-terminal domain NAb NAbs neutralization neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing epitope neutralizing epitopes neutralizing monoclonal antibodies neutralizing monoclonal antibody NTD overlapping plasma potent RBD receptor ACE2 Receptor binding domain recognizing retained S2 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants SARS-CoV-2-infected individuals specific antibodies spike The B.1.1.7 the RBD the SARS-CoV-2 variant variant of concern variants Viral viral entry [DOI] 10.1016/j.immuni.2021.03.023 PMC 바로가기 [Article Type] Article
Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-2SARS-CoV-2의 스파이크 단백질을 표적으로 하는 치료 항체 및 융합 억제제Editorial Published on 2021-06-012022-09-11 Journal: Expert opinion on therapeutic targets [Category] MERS, SARS, 진단, 치료제, [키워드] Abstract inhibitor N-terminal N-terminal domain Receptor-binding domain S2 subunit SARS-CoV-2 Spike protein the spike protein Therapeutic antibody therapeutic targets [DOI] 10.1080/14728222.2020.1820482 PMC 바로가기 [Article Type] Editorial
Comparative Transcriptomic and Molecular Pathway Analyses of HL-CZ Human Pro-Monocytic Cells Expressing SARS-CoV-2 Spike S1, S2, NP, NSP15 and NSP16 GenesArticle Published on 2021-05-312022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] antigen processing arising binding bioinformatics cell line Comparative complex complications of COVID-19 contribute COVID-19 pandemic Critical disease down-regulated down-regulated gene down-regulation Endoplasmic reticulum endoribonuclease (NSP15) enrichment analysis expression facilitate global public health heart development Heat shock Host host gene Human Immunity insulin signaling pathway Interaction methyltransferase Methyltransferase (NSP16) nervous system neurodegeneration neutrophil degranulation Nucleocapsid (NP) nucleocapsid protein offer oxidative phosphorylation pathway phosphatidylinositol 3-kinase positive Protein Regulation response RNA sequencing RNA-sequencing S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 proteins SARS-CoV-2 virus Signaling signaling pathway spike Spike S1 Spike S2 Stress target host cell transcriptomic transcriptomic alteration up-regulated viral gene viral spike virus receptor [DOI] 10.3390/microorganisms9061193 PMC 바로가기 [Article Type] Article
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infectionSARS-CoV-2 및 풍토성 코로나바이러스 감염의 스파이크 단백질에 대한 교차 반응성 혈청 및 기억 B 세포 반응Article Published on 2021-05-192022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] activated antibodies antibody Antibody Response Antibody responses assays B cells betacoronaviruses binding Cell cell population consequence convalescent coronavirus Coronavirus infection coronavirus spike protein coronavirus spike proteins Coronaviruses cross-reactive cross-reactivity Donor donors Endemic endemic human coronaviruses Evidence evidence of functional Human identify immune response immune responses Immunity in viral Infection memory B memory B cell memory B cells memory B-cell monoclonal antibodies natural infection neutralizing antibody pre-existing immunity related virus response S protein S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 serum serum antibodies serum antibody Spike protein the S protein vaccination Vaccinations viral infection viral infections [DOI] 10.1038/s41467-021-23074-3 PMC 바로가기 [Article Type] Article
In vitro cell culture model of human nasal-associated lymphoid tissue (NALT) to evaluate the humoral immune response to SARS-CoV-2 spike proteinsOriginal Article Published on 2021-04-242022-10-28 Journal: Saudi Journal of Biological Sciences [Category] COVID-19, [키워드] absence anti-S IgG antibody concentration Antibody Response Antigen appear candidate vaccine Cell Cell culture cells Cellular immune response co-cultured complete medium concerning coronavirus disease COVID-19 Culture demonstrated effort ELISA enzyme-linked immunosorbent assay evaluate full-length S full-length S protein Germany health authorities humoral immune response IgA IgM in vitro induce intranasally Lymphoid tissue Mild mononuclear cell mucosal natural infection nucleocapsid pandemic pathogenicity Patient Protein Proteins Result RPMI S protein S1 and S2 S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Saudi Arabia scientist secreted separated serious complication severe disease Significant subunit the S protein the SARS-CoV-2 tonsil used to evaluate Vaccine viral antigens Viral protein viral spike virus was used [DOI] 10.1016/j.sjbs.2021.04.051 PMC 바로가기 [Article Type] Original Article
Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein내피 세포 손상은 COVID-19의 중심 부분이며 스파이크 단백질의 S1 서브유닛을 주입하여 유도된 마우스 모델Article Published on 2021-04-012022-09-11 Journal: Annals of diagnostic pathology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Autopsy Behavior Brain Brain tissues C5b-9 caspase caspase 3 caspase-3 cell damage Complication COVID-19 demonstrated detect diagnostic died endothelial Endothelial cell endothelial cell damage endothelial damage envelope eosin examined fatal COVID-19 full length hematoxylin Hematoxylin and eosin host response IL6 immunohistochemistry increased thirst incubated injected injection Localization membrane protein Membrane proteins MFSD2a mice neurologic neurologic signs Neuron neuronal neuronal cell neuronal cells NOS pathologist pathology positive Protein Proteins pseudovirion pseudovirions S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV2 SHIP1 spike Spike protein subunit subunits symptomatic symptomatic COVID-19 tail the S1 subunit the spike protein tissue TNFα Viral RNA were used wild type [DOI] 10.1016/j.anndiagpath.2020.151682 PMC 바로가기 [Article Type] Article
SARS-CoV-2 evolution during treatment of chronic infection만성 감염 치료 중 SARS-CoV-2 진화Case Reports Published on 2021-04-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody chronic infection compensating convalescent plasma Convalescent plasma therapy convalescent plasma treatment coronavirus Course Critical Deletion deletion mutant dominant Engagement Evidence evidence of Final Frequency Genotype human Ace2 protein Immunosuppressed in vitro individuals mutant Mutation N-terminal domain Neutralizing antibodies neutralizing antibody reduced Remdesivir respiratory S2 subunit SARS-CoV-2 SARS-CoV-2 evolution sensitivity sequence Sequencing serum antibodies serum antibody severe acute respiratory syndrome Coronavirus Spike protein Substitution susceptibility the spike protein These data transferred treated Treatment Viral viral evolution viral strain viral variant Viral variants virus virus infection viruses whole-genome wild-type wild-type SARS-CoV-2 wild-type virus [DOI] 10.1038/s41586-021-03291-y PMC 바로가기 [Article Type] Case Reports
Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes경증 및 중증 COVID-19 에피소드 6개월 후 안정적인 중화 항체 수준Article Published on 2021-03-122022-09-12 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단, [키워드] Analysis anti-RBD Antibody titers asymptomatic infection carried changes conducted COVID-19 patient Diagnosis disease disease severity Durability ELISA evaluated Evidence expressing follow-up period HIV Hospitalized humoral Humoral response Hypothesis IgG antibody immune response Immunity individual initial longitudinal analysis Mild mixed-effects models neutralization Neutralizing Neutralizing activity neutralizing antibody neutralizing titers pandemic prospective cohort pseudovirus public health RBD Receptor binding domain remained reporter S2 subunit SARS-CoV-2 SARS-CoV-2 S protein severe COVID-19 significantly STABLE symptom onset symptomatic understanding Vaccine development [DOI] 10.1016/j.medj.2021.01.005 PMC 바로가기 [Article Type] Article
The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 PandemicS2의 경우: COVID-19 팬데믹과 싸우는 면역원으로서 SARS-CoV-2 스파이크 단백질의 S2 서브유닛의 잠재적 이점Immunology Published on 2021-03-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Accessibility Affect antibodies antibody Antibody-dependent enhancement Antigen antigen competition B-cells benefit common cold common cold Coronaviruses conserved coronavirus COVID-19 COVID-19 case COVID-19 cases cross-reactive Evidence exposure to Fighting glycan glycans highlight HIV-1 Immunity immunogen imperative include memory memory B-cell neutralization neutralizing antibody Perspective Population Potential potential benefit potential benefits produced Receptor-binding domain Research S2 subunit SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 vaccine similarities spike Spike protein Spike proteins stability steric T-cell T-cell responses T-cells target the receptor-binding domain the SARS-CoV-2 the spike protein therapy Vaccine Vaccine design Vaccines virus while [DOI] 10.3389/fimmu.2021.637651 PMC 바로가기 [Article Type] Immunology
The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients회복기 COVID-19 환자의 펩티드 급증을 위한 범 코로나바이러스 항체 개발의 가능성Article Published on 2021-03-062022-09-12 Journal: Archivum immunologiae et therapiae experimentalis [Category] SARS, 진단, [키워드] antibodies bind binding Blood cell entry cellular receptor collected collected data control group control patients convalescent COVID-19 patient Coronaviral coronavirus COVID-19 COVID-9 Cross reactivity cross-reactive antibody cross-reactivity decrease described Developing domain effective ELISA help heptad repeat hidden homology IgG antibody immunogenic immunoglobulins Infection infections inhibitory membrane membrane fusion MERS-CoV Middle East non-infected opposite peptide polyclonal antibody Population Potential presence of antibody raise reactivity recognize respiratory syndrome coronavirus S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection sera seropositive severity similarity spike Spike protein tested the spike protein Vaccine Viral mutations were used [DOI] 10.1007/s00005-021-00607-8 PMC 바로가기 [Article Type] Article