An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in AgingReview Published on 2021-04-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] aging alleviate cell cycle arrest cellular senescence clinical COVID-19 COVID-19 infection COVID-19 pandemic Cytokine storm DNA damage effective strategy Epidemiology health condition high mortality host receptor hyperimmune immune response immune senescence immunological increased mortality individual Inflammatory response interact mechanism pathogenic populations PROTECT public health responsible risk SARS-CoV-2 SARS-CoV-2 protein senescence senescent cell Spike protein Therapeutics translation Treatment Variation worsening [DOI] 10.14336/AD.2020.1019 PMC 바로가기 [Article Type] Review
Age reduces resistance and tolerance in malaria-infected micearticle Published on 2021-03-312024-09-01 Journal: Infection, Genetics and Evolution [Category] 말라리아, [키워드] Anemia Immunity Plasmodium yoelii senescence virulence [Article Type] article
The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?Review Published on 2021-03-152022-10-31 Journal: Cells [Category] COVID-19, [키워드] AGTR1 angiotensin Angiotensin II Anti-inflammatory Autoimmune disease cardiovascular COVID-19 COVID-19 pandemic disease Effect highlight Human human diseases Inflammation Inflammatory interact intervertebral disc involved Major neuropathic Numerous Pain pathologic pathway Pathways Perspective positive pro-inflammatory progression Protective RAS receptor regeneration Regulatory renin-angiotensin renin-angiotensin system reported role SARS-CoV 2 senescence System therapeutic strategy this system tissue Treatment vulvodynia [DOI] 10.3390/cells10030650 PMC 바로가기 [Article Type] Review
Circulating cell-free DNA species affect the risk of hepatocellular carcinoma in treated chronic hepatitis B patientsArticle Published on 2021-03-012023-06-13 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] cirrhosis hepatitis B Liver cancer senescence therapy [DOI] 10.1111/jvh.13446
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative StressPhysiology Published on 2021-01-152022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] activate Atherosclerosis cardiovascular cardiovascular disease cause Cell chronic chronic conditions chronic inflammation COVID-19 disease EndMT Endothelial cell endothelial cells Endothelial dysfunction endothelial function exacerbate excess feedback loop Health Host implication Inflammation Inflammatory inflammatory pathway initiated long-term change Lung injury Mediated mitochondrial mitochondrial dysfunction oxidative stress Pathologies pathway phenotype Potential Potential treatment promote reactive oxygen specy redox status regulate role SARS-CoV-2 SARS-COV-2 infection senescence Signaling Stress thrombosis Vascular [DOI] 10.3389/fphys.2020.605908 PMC 바로가기 [Article Type] Physiology
The Impact of Polyphenols-Based Diet on the Inflammatory Profile in COVID-19 Elderly and Obese PatientsPhysiology Published on 2021-01-122022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 acting acute respiratory distress acute respiratory syndrome ARDS CD26 characterized Clinical deterioration clinical implication Cluster comorbid disorder coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient Cytokine storm develop diet disease elderly enzyme Evidence expression high-risk population Impact individual Inflammation inflammatory disorder inflammatory status kill knowledge marker morbidity and mortality obese COVID-19 patient pandemic Pathogenesis pathology polyphenols Prevent profile promote protective effect Respiratory failure resulting SARS-CoV-2 illness SARS-COV-2 infection senescence severe COVID-19 severity syndrome therapy viral-induced virus receptor World Health Organization [DOI] 10.3389/fphys.2020.612268 PMC 바로가기 [Article Type] Physiology
Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?노화의 바이오마커로서의 기초 실험실 분석: COVID-19 치료 지원?Review Published on 2021-01-012022-09-11 Journal: Gerontology [Category] MERS, 바이오마커, [키워드] ABO blood type Adolescence age Ageing Analysis approach best Biomarker blood type C5a cause causes changes in chromosome chronological age Cluster death disease fitness focus Health status healthy Infection information laboratory assay laboratory assays large cohort life Life expectancy Medical laboratory Metrics multitude network performed plasma Plasma levels risk risk factor SARS CoV-2 SARS CoV-2 infection senescence Stage statistical the stage timeline with COVID-19 Youth [DOI] 10.1159/000517659 PMC 바로가기 [Article Type] Review
The emerging role of cellular senescence in complications of COVID-19COVID-19의 합병증에서 세포 노화의 새로운 역할Review Published on 2021-01-012022-09-12 Journal: Cancer treatment and research communications [Category] MERS, 진단, [키워드] Cancer cellular senescence Chemotherapy complications of COVID-19 coronavirus disease COVID-19 COVID-19 complication COVID-19 pandemic death eliminating Factors global change healthcare Healthcare systems higher risk highlight Older age pandemic Patient potential therapeutic target Research responsible senescence senescent cell Side effect smoking triggered [DOI] 10.1016/j.ctarc.2021.100399 PMC 바로가기 [Article Type] Review
Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV-2 Infection Severity니코틴은 기도 상피 표현형을 변화시키고 SARS-COV-2 감염 심각도를 증가시킬 수 있습니다Article Published on 2020-12-282022-09-12 Journal: Molecules [Category] MERS, SARS, 진단, [키워드] ACE2 Activation agar ATP blue Cell Cell migration cell proliferation cell viability cellular change cigarette Concentration EGFR ELISA EMT evaluated Evidence exclusion exposure to growth implicated increase increase in Infection involved Ki67 Migration mimicking mitochondrial dysfunction molecular nAChR Nicotine over-expression proliferation reduction SARS-CoV-2 SARS-COV-2 infection senescence severity substrate treated trypan blue VEGF viability viral infection western blotting [DOI] 10.3390/molecules26010101 PMC 바로가기 [Article Type] Article
Understanding immunosenescence and its impact on vaccination of older adultsArticle Published on 2020-11-262024-09-04 Journal: Vaccine [Category] 대상포진, [키워드] immune Older adults senescence Vaccine [DOI] 10.1016/j.vaccine.2020.11.002 PMC 바로가기 [Article Type] Article