The Value of Interleukin-6 among Several Inflammatory Markers as a Predictor of Respiratory Failure in COVID-19 PatientsArticle Published on 2021-07-232022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] adjusted administration Analysis Area Blood C-reactive protein can be used characteristic Clinical course coronavirus disease COVID-19 COVID-19 patients creatinine CRP D-dimer Deterioration develop Dexamethasone distress failure fraction IL-6 Inflammatory marker initiated interleukin-6 investigated Laboratory lactate dehydrogenase LDH marker novel coronavirus disease Odds ratio oxygen Patient patients predict respiratory Respiratory failure Respiratory illness retrospective severe respiratory failure significantly higher two group two groups value White blood cell with COVID-19 [DOI] 10.3390/diagnostics11081327 PMC 바로가기 [Article Type] Article
Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)SARS-CoV-2(COVID-19)에 의한 폐렴의 호흡 부전 및 사망률의 조기 예측에 헤파린 결합 단백질과 인터루킨-6의 통합Article Published on 2021-07-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] SARS, 바이오마커, [키워드] 28-day mortality Admission Biomarker Course COVID-19 Cox regression analysis creatinine cut-offs diagnostic disposition evidenced heparin Heparin-binding protein IL-6 immunoassay immunoassays independent risk factor independent risk factors integration interleukin interleukin-6 Lactate likelihood Logistic regression analysis Mortality multivariate analyses Negative predictive value outcome Oxygenation Patient patients with COVID-19 patients with pneumonia Pneumonia Positive predictive value predict Predictive Predictive value Prognosis prognostic Protein recent regression analysis remained respiratory Respiratory failure Result SARS-CoV-2 sensitivity Sepsis severe COVID-19 severe respiratory failure significantly higher specificity SRF were measured [DOI] 10.1007/s10096-020-04145-7 PMC 바로가기 [Article Type] Article
Intestinal Barrier Biomarker ZO1 and Endotoxin Are Increased in Blood of Patients With COVID-19-associated PneumoniaCOVID-19 관련 폐렴 환자의 혈액에서 장 장벽 바이오마커 ZO1 및 내독소 증가Article Published on 2021-07-012022-09-11 Journal: In vivo (Athens, Greece) [Category] SARS, 바이오마커, [키워드] Admission analysed Bacterial bacterial translocation barrier Biomarker blood sample Blood samples C-reactive protein circulation Clinical course clinical courses collected community-acquired pneumonia Concentration control group COVID-19 COVID-19 pneumonia dysfunction Endotoxemia endotoxin ferritin Gut Gut barrier healthy healthy controls hospitalized patient Increased intestinal mechanical ventilation no difference no significant difference no significant differences on admission Patient Pneumonia positively correlated prognostic progression Prospective Study Respiratory failure serum Serum level serum levels severe respiratory failure significantly higher SRF systemic circulation translocation were recorded with COVID-19 ZO1 zonula [DOI] 10.21873/invivo.12528 PMC 바로가기 [Article Type] Article
Low-Dose Tocilizumab With High-Dose Corticosteroids in Patients Hospitalized for COVID-19 Hypoxic Respiratory Failure Improves Mortality Without Increased Infection RiskCOVID-19 저산소 호흡기로 입원 한 환자에서 고용량 코르티코 스테로이드가있는 저용량 토 실리 주맙Multicenter Study Published on 2021-06-282022-09-01 Journal: The Annals of Pharmacotherapy [Category] MERS, 진단, [키워드] 28-day mortality 95% CI Adult patients adult respiratory distress syndrome Analysis balance benefit Biomarker Combination combination therapies combination therapy Corticosteroid Corticosteroids COVID-19 COVID-19 pneumonia COVID-19 treatment Dexamethasone dexamethasone 6 mg dosage failure group hazard ratio high mortality hypoxia hypoxic respiratory failure Increased Infection Inflammation Interleukins medication therapy management Modification Mortality objective Patient patients with COVID-19 Pneumonia present reduction in mortality Relative risk Relevance respiratory Respiratory failure respiratory infections Result Retrospective study risk risk of infection Secondary infection severe respiratory failure Standard of care steroid supportive therapy survival therapeutic effect therapy Tocilizumab Treatment was performed were assessed [DOI] 10.1177/10600280211028882 PMC 바로가기 [Article Type] Multicenter Study
The U-shaped association of serum iron level with disease severity in adult hospitalized patients with COVID-19Observational Study Published on 2021-06-282022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료법, [키워드] adjusted age and sex analyzed association Coronavirus disease 2019 COVID-19 COVID-19 severity demonstrated disease severity Diseases exacerbating groups hospitalized COVID-19 patient hospitalized patient Host Infectious disease Infectious diseases initial Mild mitigate Multivariate analysis no significant difference pathogenic Patient patients serum severe respiratory failure significantly significantly higher significantly lower tissue damage Transferrin Trigger viral infection with COVID-19 [DOI] 10.1038/s41598-021-92921-6 PMC 바로가기 [Article Type] Observational Study
Respiratory Failure in an Extremely Premature Neonate with COVID-19Case Report Published on 2021-06-042022-10-31 Journal: Children [Category] COVID-19, [키워드] C-reactive protein children Clinical course Coronavirus disease 2019 Course COVID-19 Day deficiency Dexamethasone elevated failure higher risk hypoxic respiratory failure immature immunocompromised status Immunosuppression implication Infant Infants Infection intensive care Lung disease Lungs management mild infection mother nasal Neonatal Neonate NICU non-invasive ventilation oxygen Oxygen requirement positive Premature Prematurity Prevent Prolonged protocol respiratory Respiratory failure risk factor RT-PCR SARS-CoV-2 severe respiratory failure Spread the disease treated unique ventilatory support virus with COVID-19 worsening [DOI] 10.3390/children8060477 PMC 바로가기 [Article Type] Case Report
Clinical characteristics and respiratory support of 310 COVID-19 patients, diagnosed at the emergency room: a single-center retrospective studyObservational Study Published on 2021-06-012022-10-04 Journal: Internal and Emergency Medicine [Category] 임상, [키워드] airway analyzed case sery Characteristics clinical Clinical course cohort of patient consecutive patients Continuous COVID-19 COVID-19 patients CPAP CPAP (continuous positive airway pressure) diagnosed discharged discharged home DNI Emergency Epidemiology high mortality rate Hospitalization Intubated Italy lombardy mechanical ventilation mortality rate NIV NIV (non-invasive ventilation) Non-invasive occurred outbreak outcome overall mortality oxygen oxygen only oxygen support Patient patients patients died patients treated Pneumonia poor prognosis positive pressure Respiratory Coronavirus Respiratory Support retrospective Retrospective study room SARS-CoV-2 SARS-COV-2 infection severe respiratory failure single-center Support therapy threshold Throughout the study treated Treatment ventilator with COVID-19 [DOI] 10.1007/s11739-020-02548-0 PMC 바로가기 [Article Type] Observational Study
Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19Research article Published on 2021-06-012022-10-05 Journal: European journal of internal medicine [Category] SARS, 치료법, [키워드] acute respiratory distress acute respiratory syndrome Administered administration adverse event Algorithm Anakinra applied Arm baseline Combination combination treatment comparator Coronavirus-2 Corticosteroid COVID-19 death rate Endpoint ferritin Hypothesis IL-1 IL-6 immune Immunomodulatory agent IMPROVE independent risk factors inflammatory process Intervention intubation lesson management median age moderate disease Mortality mortality rate Older age Patient patients patients with COVID-19 Respiratory failure Result SARS-CoV-2 Secondary infection severe respiratory failure Significant significantly higher single dose Standard-of-care survival syndrome Tocilizumab treated Treatment with COVID-19 [DOI] 10.1016/j.ejim.2021.03.026 [Article Type] Research article
Clinical Characteristics, Management, and Outcome of the First 19 Patients With Pneumonia Due to the 2019 Novel Coronavirus Disease Treated in an Intensive Care Unit in the Republic of CyprusInternal Medicine Published on 2021-05-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute kidney injury acute respiratory syndrome Admission affected age AKI analyzed anonymously association caused children clinical co-morbidities collected consequence contrary contributed coronavirus coronavirus disease correlated COVID-19 COVID-19 patient COVID-19 positive patient Critically ill critically ill patients Cyprus death determine died discharged eight four group Gender Health healthcare personnel Healthcare system Hospitalization hypertension ICU ICU admission IMPROVE increased mortality intensive care intensive care unit Invasive mechanical ventilation male management mechanical ventilation median men Microsoft Corporation Microsoft Excel Mortality Nicosia novel obese obesity outcome outcomes Patient patients PEEP phenotype polymerase chain Positive end-expiratory pressure positive result progression prone Prone position prospective observational study Remdesivir required Result risk factor RT-PCR SARS-CoV-2 severe respiratory failure study period suggested the patient understanding vasopressor support Ventilation was used were excluded widespread women [DOI] 10.7759/cureus.15114 PMC 바로가기 [Article Type] Internal Medicine
Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation호흡기 장애, 중증 폐렴 및 과염증이 있는 COVID-19 환자에서 IL-1 및 IL-6 차단에 대한 반응 예측Clinical Trial Published on 2021-04-292022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, [키워드] administration Anakinra anti-cytokine therapy anti-cytokine therapy initiation coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patient Cytokines Efficacy Evidence evidence of Follow-up hyper-inflamed COVID-19 patient hyper-inflamed COVID-19 patients identify IL-1 IL-6 IL-6 blockade IL-6 blocking inhibitor initiated interleukin interleukin (IL)-1 interleukin-1 interleukin-6 median Mortality objective PaO Patient patients treated pro-inflammatory cytokine pro-inflammatory cytokines provided reduced respiratory Respiratory failure respiratory impairment response Restraining maladaptive inflammation Result sarilumab SARS-CoV-2 selective severe coronavirus disease severe hyper-inflamed COVID-19 patients severe respiratory failure significantly higher Standard of care Standard therapy stratified survival survival rate therapeutic therapy Tocilizumab treat treated Treatment treatment failure treatment initiation treatment with biologics window [DOI] 10.3389/fimmu.2021.675678 PMC 바로가기 [Article Type] Clinical Trial