Novel Therapeutic Target(s) for Psoriatic DiseaseReview Published on 2022-02-212024-09-02 Journal: Frontiers in Medicine [Category] 대상포진, [키워드] Autoimmune hepatitis biologics and biosimilars infliximab monotherapy psoriasis psoriatic arthritis small molecule Treatment [DOI] 10.3389/fmed.2022.712313 PMC 바로가기 [Article Type] Review
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples Research Published on 2022-02-072022-10-05 Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] biofluid biofluids Concentration controls Cycle threshold value DNA double-stranded flexible ions less molecular nasopharyngeal sample nucleic acid nucleic acid amplification patients with COVID-19 probe Proteins Rapid RNA extraction SARS-CoV-2 SARS-CoV-2 RNA single-stranded DNA small molecule thrombin [DOI] 10.1038/s41551-021-00833-7 [Article Type] Research
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method천연 MS 기반 친화성 선택 방법을 사용하여 허브 추출물에서 SARS-CoV-2 3C 유사 프로테아제에 대한 잠재적 억제제의 효율적인 발견Article Published on 2022-02-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL 3CL Protease 3CLpro acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied baicalein binding affinity characterized China Cirsium complexes Compound compounds conducted Coronaviral coronavirus COVID-19 COVID-19 therapy Data acquisition Data processing Effectiveness efficient effort flavonoids Forsythia fraction Fractions Glycyrrhiza uralensis identify incubated Infection inhibitor investigated life cycle Ligand Lonicera japonica Native Native MS natural natural product outcomes protease protein-ligand resources SARS-CoV-2 scutellarein Scutellaria baicalensis severe acute respiratory syndrome Coronavirus small molecule Standard TCM therapy Traditional Chinese medicine traditional Chinese medicines Treatment UHPLC Virus life cycle were used [DOI] 10.1016/j.jpba.2021.114538 PMC 바로가기 [Article Type] Article
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistanceSARS-CoV-2 변이체의 새로운 돌연변이와 항체가 소분자 기반 치료 내성으로 탈출하는 역할Review Published on 2022-02-012022-09-11 Journal: Current opinion in pharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Antiviral article candidate Clinical stages clinical trial clinical trials COVID-19 pandemic effective Genome identify Major Mutation mutations Neutralizing antibodies neutralizing antibody RdRP RdRp mutations Remdesivir SARS-CoV-2 variant SARS-CoV-2 variants small molecule the SARS-CoV-2 therapeutic variant [DOI] 10.1016/j.coph.2021.11.006 PMC 바로가기 [Article Type] Review
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection실리코 분석은 SARS-CoV-2 감염에 의해 유발된 사이토카인 폭풍을 잠재적으로 조절하는 약물을 식별합니다Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] “cytokine storm” addition Analysis anti-inflammatory properties anti-inflammatory property approach BALF Bronchoalveolar lavage fluid cause causes Computational biology and bioinformatics connectivity COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient Cytokines Data mining dataset drug Effect expected female hormone glucocorticoid Glucocorticoids Health help human cell lines identify immune response immune responses in silico analysis in vitro data Inflammatory Map MEK inhibitor modulating molecules Mortality negative regulation pathology pathway Pathways PKC predicted reveal SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules supported the cytokine storm these compounds Transcription Transcriptome transcriptomic data Treatment triggered [DOI] 10.1038/s41598-022-05597-x PMC 바로가기 [Article Type] Article
A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung CellsSARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다Article Published on 2022-01-262022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle [DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infectionSARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.Comparative Study Published on 2022-01-242022-09-10 Journal: eLife [Category] 변종, 치료기술, 치료제, [키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type [DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study
Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein자기 마이크로비드 친화성 선택 스크리닝의 발전: SARS-CoV-2 스파이크 단백질에 대한 천연 리간드의 발견Article Published on 2022-01-052022-09-11 Journal: Journal of the American Society for Mass Spectrome [Category] Coronavirus, SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance affinity Amino acid amino acid sequence angiotensin Angiotensin converting enzyme-2 antibodies applied approaches binding caused complex coronavirus COVID-19 enzyme glycyrrhiza High-resolution HPLC human ACE2 human cell human cells include Interaction licochalcone a Ligand ligands Like mass spectrometry Microbead natural peptide pharmacological Prevent Protein subunit receptor robotics S1 protein SARS-CoV-2 SARS-COV-2 infection Selection sensitivity sequence severe acute respiratory syndrome Coronavirus small molecule Small molecules spike Spike protein subunit Tandem mass spectrometry targets the S1 protein the SARS-CoV-2 therapeutic agent therapeutic agents throughput treat virus spike protein [DOI] 10.1021/jasms.1c00318 PMC 바로가기 [Article Type] Article
Small molecule interactions with the SARS-CoV-2 main protease: In silico all-atom microsecond MD simulations, PELE Monte Carlo simulations, and determination of in vitro activity inhibitionSARS-CoV-2 주요 프로테아제와의 소분자 상호작용: 인실리코 전 원자 마이크로초 MD 시뮬레이션, PELE 몬테카를로 시뮬레이션 및 시험관 내 활성 억제 결정Article Published on 2022-01-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral caused clinical evaluation clinical trials concentrations coronavirus COVID-19 COVID-19 pandemic Critical Cyanidin-3-O-glucoside demonstrated domain dose-dependent manner Effective vaccines enzymatic activity eradication experiments FDA GC376 glucoside highlight Hypericin in vitro in vitro activity inhibit inhibitor Interaction less Ligand ligands M pro main protease MD simulations molecular molecular dynamics Molecular modelling notable Orphan Drug performed positive control Previous studies protease respiratory Safe SARS-CoV-2 SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus situation small molecule stability the SARS-CoV-2 Trajectories Vaccine hesitancy variants of concern was used [DOI] 10.1016/j.jmgm.2021.108050 PMC 바로가기 [Article Type] Article
Drug similarity and structure-based screening of medicinal compounds to target macrodomain-I from SARS-CoV-2 to rescue the host immune system: a molecular dynamics study숙주 면역계를 구하기 위해 SARS-COV-2로부터 마크로 도메인 -I를 표적화하기위한 약용 화합물의 약물 유사성 및 구조 기반 스크리닝 : 분자 역학 연구Article Published on 2022-01-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] active site ADPr Analysis approaches cause caused Compound coronavirus Critical docking docking score drug drug similarity drug target free energy Free energy calculations help Host host immune system identify immune immune system in viral Infection inhibit Interaction macrodomain Macrodomain-I molecular molecular dynamics Molecular dynamics simulation outbreak positive control public health repeated Replication reported researcher residue residues risk SARS-CoV-2 screened severe pneumonia significantly similarity small molecule small molecule inhibitor Small molecule inhibitors structure-based screening targets the disease these compound these compounds vaccine candidate vaccine candidates Viral viral replication Virtual screening Wuhan Wuhan, China [DOI] 10.1080/07391102.2020.1815583 PMC 바로가기 [Article Type] Article