Transmissible gastroenteritis virus infection decreases arginine uptake by downregulating CAT-1 expressionResearch Article Published on 2018-09-202022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] Activation amino acid transporter Analysis arginine cationic cause coronavirus decrease diarrhea downregulating Effect epithelial cell line evaluated expression growth factor hpi HPLC infect Infection intestinal intestinal epithelial cells investigated involved mechanism phospho-protein Post-infection receptor reduced target TGEV transmissible gastroenteritis virus [DOI] 10.1186/s13567-018-0591-1 PMC 바로가기 [Article Type] Research Article
Impact of TGEV infection on the pig small intestineResearch Published on 2018-06-192022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Analysis Bacterial cause CD3 Cell cell proliferation cytokine DCs dendritic cell diarrhea Effect Enterobacteriaceae evaluated facilitate help high mortality IL-10 IL-1β IL-6 immune functions Impact impair in vivo increase Infection lactobacillus less Mortality mRNA expression mucosal pathogenic pathogenic mechanism Pathogens pig positive cells reduced Result Secondary infection SIgA significantly small intestine survived T cells TGEV TGF-β TNF-α transmissible gastroenteritis virus [DOI] 10.1186/s12985-018-1012-9 PMC 바로가기 [Article Type] Research
Contribution of porcine aminopeptidase N to porcine deltacoronavirus infectionArticle Published on 2018-04-112022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] adopted alphacoronavirus amino acid sequence aminopeptidase N Analysis antibody BHK-21 cell blocked C-terminal domain Cell Cluster Contact coronavirus CoV CoVs Critical effort Evolution explain expression functional gastroenteritis Infection information inhibitor Interaction intestinal epithelial cells involved Porcine deltacoronavirus Protein receptor receptors recognize residue Support susceptible TGEV Treatment turn Variation virus [DOI] 10.1038/s41426-018-0068-3 PMC 바로가기 [Article Type] Article
microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro *Research Published on 2018-02-072022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] Coronavirus, [키워드] Accessory activating Activation addition adopted aggravate Analysis Cell damage demonstrated diarrhea differentially expressed downregulated Effect elevated expression IL1RAP Infection interleukin-1 investigated kidney MAPK mitochondrial Mitochondrial function mitochondrial membrane potential p38 MAPK signaling pathway PK-15 positive previous study Protein proteomic Quantitative RB1 receptor reduced Regulatory retinoblastoma suppressed target targeting TGEV transmissible gastroenteritis virus upregulated Via [DOI] 10.1074/mcp.RA117.000432 PMC 바로가기 [Article Type] Research
Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon- β through Its Deubiquitinase ActivityResearch Article Published on 2017-10-232022-10-27 Journal: BioMed Research International [Category] Coronavirus, [키워드] activity acute respiratory syndrome catalytic activity coronavirus CoV CoVs dependent on deubiquitinase DUB epidemic diarrhea Evidence expression gastroenteritis HCoV-NL63 Host host innate immunity IFN inhibit inhibited innate immune response interfere interferon interferon regulatory factor IRF3 mechanism MERS-CoV MHV Middle East murine hepatitis virus NL63 nuclear translocation PEDV Production protease respiratory SARS-CoV Sendai virus Signaling suppress TGEV virus [DOI] 10.1155/2017/7089091 PMC 바로가기 [Article Type] Research Article
Detection and phylogenetic analyses of spike genes in porcine epidemic diarrhea virus strains circulating in China in 2016–2017Short Report Published on 2017-10-102022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition Amino acid Analysis analyzed Characteristics China Chinese circulating classical collected Complete contribute detection diarrhea epidemic diarrhea Epidemiology gastroenteritis Genetic genetic diversity Hainan identity indicated insertion island knowledge Molecular epidemiology nucleotide outbreak Pathogens PCR PEDV Phylogenetic analysis Porcine deltacoronavirus positive Result S gene sequenced Sequencing spike gene strain TGEV the epidemic the vaccine vaccine strain virulent virus virus strain [DOI] 10.1186/s12985-017-0860-z PMC 바로가기 [Article Type] Short Report
Immunogenicity of eGFP-Marked Recombinant Lactobacillus casei against Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea VirusArticle Published on 2017-09-252022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute diarrhea Administered antibiotic antibiotic-free selection antibody Antigen antigenic site develop effective eGFP epidemic diarrhea evaluated expression fluorescent gastroenteritis IgG immunized immunized mice immunogenicity immunogens Immunoglobulin immunoglobulin A Infection Lactobacillus casei Lymphocytes mice Microscopy mucosal Neutralizing neutralizing effect Oral vaccine PBS PEDV phosphate-buffered saline Porcine epidemic diarrhea virus proliferation Protein provide recombinant reporter resulting S protein Safe secreted serum serum IgG antibody significantly higher TGEV transmissible gastroenteritis virus Vaccine development virus was used were used [DOI] 10.3390/v9100274 PMC 바로가기 [Article Type] Article
Ultrastructural Characterization of Membrane Rearrangements Induced by Porcine Epidemic Diarrhea Virus InfectionArticle Published on 2017-09-052022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] alpha-coronavirus approach cause characterization coronavirus Course CoV drastic electron microscopy Endoplasmic reticulum epidemic diarrhea examined form gastroenteritis Golgi high mortality host cell membrane immature induced Infection lifecycle membrane membrane rearrangement Microscopy organelle PEDV promote Rearrangement Replication resulting secretory pathway similarity TGEV Vesicle viral particle virus [DOI] 10.3390/v9090251 PMC 바로가기 [Article Type] Article
Identification of a natural recombinant transmissible gastroenteritis virus between Purdue and Miller clusters in ChinaOriginal Article Published on 2017-08-232022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] breakpoint cause China Cluster Clusters Complete computational analysis coronavirus CoV evaluated Evolution facilitate Frame gastroenteritis genome sequence identification infective information Miller molecular morbidity and mortality natural recombinant ORF1a Pathogenesis pathogenic pathogenicity Phylogenetic tree Recombination small intestine TGEV transmissible gastroenteritis virus virus [DOI] 10.1038/emi.2017.62 PMC 바로가기 [Article Type] Original Article
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral ActivityArticle Published on 2017-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activities activity approach block cells cellular combination treatment Compound Comprehensive Coronaviral Coronaviruses dominant effective feasible host cell Infection inhibit inhibition inhibitor IκBα Jak JAK2 mechanisms Mediated MERS-CoV NF-κB NF-κB activation p65 pathway Pathways Phosphorylation pro-inflammatory response Regulation Replication SARS-CoV target targeting TGEV Treatment viral infection Viral RNA virus [DOI] 10.1038/s41598-017-04203-9 PMC 바로가기 [Article Type] Article