mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primatesmRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA [DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boostSARS-CoV-2 mRNA 부스트 후 증가된 기억 B 세포 효능 및 폭Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] accompanied analysed antibody breadth Cell clone clones Cohort consequence conserved conserved regions convalescent individual disease domain dose effective Evolution expansion explain help increase in Increased individual Infection memory memory B memory B cell memory B cells Memory cells mRNA boost mRNA vaccine neutralized Neutralizing antibodies neutralizing antibody omicron Omicron variant potency PROTECT receiving Receptor-binding domain reduced Region respond SARS-CoV-2 second dose significantly increased the RBD these cell These cells These data Vaccine variant variant of SARS-CoV-2 variants [DOI] 10.1038/s41586-022-04778-y PMC 바로가기 [Article Type] Article
Impact of breakthrough COVID-19 cases during the omicron wave on vascular health and cardiac autonomic function in young adults오미크론파 중 획기적인 COVID-19 사례가 젊은 성인의 혈관 건강 및 심장 자율 기능에 미치는 영향Article Published on 2022-07-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] COVID19(2023년), SARS, 변종, [키워드] Adults age appear arterial Arterial stiffness autonomic Breakthrough infection cardiac baroreflex sensitivity Cardiovascular health Control COVID-19 COVID-19 case detrimental Diagnosis endothelial endothelial function females flow-mediated dilation group Health healthy heart rate heart rate variability hyperemia Impact impairment investigated less macro measure not different omicron Omicron variant preserved pulse Pulse wave pulse wave velocity reactive reactive hyperemia Research sensitivity severe complications shown These data Variability variant Vascular was determined were assessed with COVID-19 [DOI] 10.1152/ajpheart.00189.2022 PMC 바로가기 [Article Type] Article
Serosurveillance after a COVID-19 vaccine campaign in a Swiss police cohort스위스 경찰 집단에서 COVID-19 백신 캠페인 후 혈청 감시Article Published on 2022-07-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] 치료법, [키워드] age anti-NCP-antibodies anti-S antibody anti-S-antibodies. anti-spike antibody antibody Antibody titer association baseline calculated Cohort Comorbidity COVID-19 COVID-19 seroprevalence COVID-19 vaccine cross-sectional demonstrated Department Follow-up visit General population had no healthcare professionals Infection infection rate male nucleocapsid protein online questionnaires participant performed reported resulting risk SARS-CoV-2 Seroconversion Seroprevalence Spike protein study participant Study participants study population These data U/mL vaccination vaccination rate vaccination rates vaccine dose was performed [DOI] 10.1002/iid3.640 PMC 바로가기 [Article Type] Article
Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination in Kidney Transplant Recipients신장 이식 수혜자에서 mRNA SARS-CoV-2 백신 접종 후 획기적인 감염Article Published on 2022-07-012022-09-11 Journal: Transplantation [Category] COVID19(2023년), SARS, 변종, [키워드] 95% confidence interval administration age Analysis analyzed BNT162b2 BNT162b2 vaccine breakthrough infections clinical clinical effectiveness clinical picture collected confirmation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity death died dose excluded General population hazard ratio hospitalized patients independent risk factor independent risk factors kidney transplant Mortality mRNA mRNA vaccine mRNA-1273 mRNA-1273 vaccine multivariable analysis Nephrology no difference no differences not improved outcome Patient Pneumonia receiving recipient registry remained Research SARS-CoV-2 significantly lower Society Spanish survival survival analysis These data Transplant vaccination Vaccination Status Vaccine vaccine doses variant with COVID-19 [DOI] 10.1097/TP.0000000000004119 PMC 바로가기 [Article Type] Article
Evaluation of humoral and cellular response to third dose of BNT162b2 mRNA COVID-19 vaccine in patients treated with B-cell depleting therapyB세포 고갈 요법으로 치료받은 환자에서 BNT162b2 mRNA COVID-19 백신 3차 접종에 대한 체액 및 세포 반응 평가Article Published on 2022-07-012022-09-11 Journal: Journal of autoimmunity [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] affected anti-CD20 anti-S anti-SARS-CoV-2 antibody Autoimmune disease B-cell BNT162b2 CD-20 CD20 cellular immunity cellular response Cohort COVID-19 COVID-19 vaccination COVID-19 vaccine depleting dose doses drug group healthy control healthy controls humoral humoral and cellular immunity IFN-g IgG IMID Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunogenic immunogenicity Immunosuppressed immunosuppressed patient immunosuppressed patients Inflammatory diseases interferon mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines naïve Neutralization assay neutralization assays neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody no significant difference of BNT162b2 Patient patients treated Quantitative reduced response seroconverted significant difference significantly spike subject therapy These data treated vaccination [DOI] 10.1016/j.jaut.2022.102848 PMC 바로가기 [Article Type] Article
Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysisSARS-CoV-2 항체 수준의 종단적 변이와 바이러스 변이체의 출현: 혈청학적 분석Article Published on 2022-07-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] absence Analysis antibody antibody levels Antibody Response Antibody responses Antibody titre assays baseline Clinical practice Cohort correlation correlation analyses COVID-19 vaccine declined detectable Deterioration determine determined by Effect facilitate functional Immunity individual Infection longitudinal MONITOR National Health Service neutralisation activity neutralisation assays neutralising Neutralising activity neutralising antibody titre neutralising antibody titres nucleocapsid participants with SARS-CoV-2 Post-infection predict Predictive Predictive value presence or absence SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivities sensitivity serological analysis Serological assay serological assays serological measurement serological measurements serological test Serological tests serum sample serum samples Spearman Spike protein Spike protein sequence subsequent Surrogates the spike protein These data threshold timepoint timepoints titres two-tailed variants variants of concern Variation Viral viral variant Viral variants [DOI] 10.1016/S2666-5247(22)00090-8 PMC 바로가기 [Article Type] Article
A cautionary note on altered pace of aging in the COVID-19 era코로나19 시대 고령화 속도 변화에 대한 주의사항Article Published on 2022-07-012022-09-11 Journal: Forensic science international. Genetics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accumulated acute respiratory syndrome Affect age aging all-cause mortality Alter Blood chronological age Clinical research CLOCK confounder Corona virus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 pandemic DNA methylation DNA methylation markers Effect Epigenetic Forensic Forensic age estimation heterogeneous nature Immune cell immune cells immune response individual individuals Interpretation joint life style management marker Modification modify molecular mortality risk pace pandemic pathogen Pathogens Pathologies pathology performed persistence Perturbation perturbations reliability Research respiratory risk SARS-CoV-2 SARS-CoV-2 pandemic scar Severe acute respiratory syndrome SjTREC syndrome T-cell receptor telomere Telomere Length the SARS-CoV-2 These data vaccination virus [DOI] 10.1016/j.fsigen.2022.102724 PMC 바로가기 [Article Type] Article
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection바이러스 부하는 급성 중증 SARS-CoV-2 감염에서 미토콘드리아 기능 장애 및 변경된 단핵구 표현형과 관련이 있습니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD16 CD39 Cell cell surface classical monocyte classical monocytes Clinical outcome COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determined by evaluated exhibited expression Frequency GM-CSF healthy control healthy controls high viral load HLA-DR Hospital admission IFN-α Immune checkpoints induce Infection initial innate immune innate immune response less membrane Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function monocyte Monocyte activation Monocytes oxygen pathological mechanism patients PD-1 phenotype reactive oxygen species reactive oxygen specy SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe SARS-CoV-2 severity the cell the median These data Viral viral burden Viral load with COVID-19 [DOI] 10.1016/j.intimp.2022.108697 PMC 바로가기 [Article Type] Article
Contrasting Epidemiology and Population Genetics of COVID-19 Infections Defined by Multilocus Genotypes in SARS-CoV-2 Genomes Sampled Globally전 세계적으로 샘플링된 SARS-CoV-2 게놈의 다중 유전자형에 의해 정의된 COVID-19 감염의 대조 역학 및 인구 유전학Article Published on 2022-06-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] aligned allele frequency alleles Alpha Amino acid amino acids Analysis Asia association Beta caused Cluster Clustering codon component continent continuous surveillance COVID-19 COVID-19 case COVID-19 incidence COVID-19 vaccine COVID-19 vaccines criteria deaths delta variant demographic data demographics demonstrated dependent on discriminant analysis distribution eight epidemiological Epidemiology Evolution Gamma Genetic genetics Genome genomes Genomic surveillance Genotype genotyping geographical regions GISAID help higher risk Inclusion inclusion criteria Intervention linkage Local loci majority matrix MONITOR multilocus Mutation mutation and transmission. North North America nucleocapsid older patient older patients ORF1ab ORF3a ORF8 persistence polymorphism Population populations predominant Prevalence reference genome repertoire Result risk of infection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 reference genome selected South America spatiotemporal Spread suggested the SARS-CoV-2 These data Transmission utility variant variants variants of concern Viral transmission VoC VOCs younger patient younger patients [DOI] 10.3390/v14071434 PMC 바로가기 [Article Type] Article