TLR7 – Page 6 – Communicable Diseases Research

IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

SARS-CoV-2에 대한 IL-33 발현은 COVID-19 회복기 개인의 혈청 양성과 상관관계가 있습니다

Article

Published on 2021-04-092022-09-12
Journal: Nature Communications [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법,

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Research

Published on 2021-04-012022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

Rare variants increase the risk of severe COVID-19

희귀 변종은 심각한 COVID-19의 위험을 증가시킵니다

Comment

Published on 2021-03-232022-09-10
Journal: eLife [Category] SARS, 변종,

[키워드] COVID-19 form Human LASSO Logistic Regression Analysis loss-of-function medical history men risk severe COVID-19 severe forms of COVID-19 TLR7 TLR7 gene variant
[DOI] 10.7554/eLife.67860 PMC 바로가기 [Article Type] Comment

Immunogenetic Predictors of Severe COVID-19

Review

Published on 2021-03-032022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] ACE-2 Analysis analyzed article articles association assumed Biomarkers CCR9 Characteristics Clinical studies complications Corona virus coronavirus Coronavirus infection Course COVID-19 criteria CXCR6 Cytokine storm database described develop diagnostic disease enzyme ERAP2 expression Factor Gene Expression Genes Genetic Genotype HLA immune response immunogenic immunological parameters Infection life-threatening likelihood literature review marker men Mutation New New coronavirus new coronavirus infection overexpression Patient Polymorphisms predictor Protein SARS-CoV-2 selected severe COVID-19 the disease thrombosis TLR7 TMPRSS2 wild-type
[DOI] 10.3390/vaccines9030211 PMC 바로가기 [Article Type] Review

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

남성에서 생명을 위협하는 COVID-19 질병과 Toll 유사 수용체 7 변이의 연관성: 중첩 사례 대조 연구의 결과

Short Report

Published on 2021-03-022022-09-10
Journal: eLife [Category] SARS, 변종, 유전자 메커니즘,

[키워드] affected Analysis applied Asymptomatic case-control study clinical Cohort conditioned contributing to Control COVID-19 Deleterious demonstrated disease disease susceptibility disorder Donor expression profile extreme functional gene funding GEN-COVID Gene Expression Human iceberg IFN impairment initiative investigated Italian LASSO Logistic Regression Analysis life-threatening COVID-19 disease loss-of-function male male participant male participants participant Participants Patient patients phenotype rare variant Rare variants reduction in Regression regression analysis responses SARS-CoV-2 selected Severe case severe COVID-19 subset susceptibility TLR7 toll-like receptor 7 Trial type I variant X-linked
[DOI] 10.7554/eLife.67569 PMC 바로가기 [Article Type] Short Report

Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions

Review

Published on 2021-02-202022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

[키워드] “cytokine storm” activate Activation acute lung injury acute lung injury (ALI) acute respiratory distress acute respiratory distress syndrome (ARDS) Bacterial Bacterial coinfection characteristic characterized Combination coronavirus COVID-19 Cytokine release syndrome Cytokine storm effective eight Evidence exhibiting fungal fungal coinfection Fungal infection fungal infections healthy control hyperinflammation implication Infection Innate Innate immunity Interaction Involving Making mechanism melatonin microbes Mild mild cases mild COVID-19 patient Model NLR NLRP3 novel nucleotide-oligomer-recognition-domain-like receptors (NLR) oligomerization outlined pattern prediction receptor respiratory resulting review SARS-CoV-2 Sepsis severe COVID-19 severe COVID-19 patients suggestion Symptoms syndrome synergistic synergy therapeutic TLR TLR antagonists TLR2 TLR3 TLR4 TLR7 TLR9 Toll-like receptor toll-like receptors (TLR) treating COVID-19
[DOI] 10.3390/ijms22042108 PMC 바로가기 [Article Type] Review

Analysis of chicken macrophage functions and gene expressions following infectious bronchitis virus M41 infection

Research Article

Published on 2021-01-282022-10-28
Journal: Veterinary Research [Category] Coronavirus,

[키워드] analyzed Apoptosis autophagy biological process bronchitis CCL4 CD36 Cell change CXCL12 expression expressions function Gene Expression Host host immune responses IBV IBV infection IBV-infected cells IFN-α IFN-γ IL-10 IL-1β IL-6 immune response Immunity Infection Infectious Bronchitis Virus Inflammation Interaction involved M41 Macrophage macrophage cell line Marco MDA5 MHCII MIF MOI morbidity and mortality multiplicity of infection pathogen pathogenic coronavirus Peripheral blood phagocytic Protein receptor Result significantly higher TLR3 TLR7 TNF-α viability virus virus replication were infected XCL1
[DOI] 10.1186/s13567-021-00896-z PMC 바로가기 [Article Type] Research Article

Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro

시험관 내 SARS-CoV-2 감염에 대한 락토페린의 보호 효과

Article

Published on 2021-01-232022-09-10
Journal: Nutrients [Category] MERS, 진단, 치료제,

[키워드] analyzed anti-inflammatory cytokine Anti-inflammatory effects Antiviral antiviral immune response antiviral immunity Caco-2 Caco-2 cell Caco-2 cells COVID-19 curative cytokine determined by Effect epithelial cells expression Gene Expression Genes glycoprotein IFNA1 IFNB1 immune immune response immune response gene immunomodulatory immunostaining in vitro in vitro data Infection inhibited intestinal epithelial cell intestinal epithelial cells IRF3 IRF7 lack lactoferrin MAVS moderate non-toxic Plaque assay qRT-PCR Replication SARS-CoV-2 SARS-COV-2 infection significantly Support TLR3 TLR7 treated uninfected virus was determined was performed
[DOI] 10.3390/nu13020328 PMC 바로가기 [Article Type] Article

An overview of Betacoronaviruses-associated severe respiratory syndromes, focusing on sex-type-specific immune responses

Review

Published on 2021-01-102022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS,

[키워드] Abstract Activation acute respiratory illness Anti-viral approaches autoimmune reactions beta-coronavirus bi-allelic blood circulation coronavirus COVID-19 COVID19 disease epidemiological expression Fatality rate feature female females Frequency Genes Host immune response IFN immune Immune cell immune protection immune response immune responses immune system Immunotherapy inactive Infection infection rate information involved less male MERS MERS-CoV Middle East pathogen Regulatory respiratory respiratory infection responsible robust SARS SARS-CoV-1 SARS-CoV-2 similarity susceptibility susceptible the antibody TLR7 Treatment Vaccine development Variation viral infections Viral load X-linked β-CoVs
[DOI] 10.1016/j.intimp.2021.107365 PMC 바로가기 [Article Type] Review

Virus in the pathogenesis of inflammatory bowel disease: role of Toll-like receptor 7/8/3

Review Article

Published on 2021-01-012022-10-31
Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19,

[키워드] Activation antagonist antiviral immune responses association bowel cause COVID-19 Critical Crohn’s disease dendritic cells effective evaluated expressed finding help IBD IL-1 IL-6 immune system IMPROVE incidence induce Inflammation Inflammatory Inflammatory bowel disease Inflammatory mediators Influenza inhibitors innate immune interferons (IFNs involved less molecular mechanism Pathogenesis Patient patients Quality of life receptor receptors regulate SARS-CoV-2 shown the disease Therapies TLR TLR pathways TLR7 TLR8 TLRs Toll-like receptor Toll-like receptors Treatment ulcerative colitis understanding Vaccine viral infection virus
PMC 바로가기 [Article Type] Review Article