VEGF – Page 6 – Communicable Diseases Research

miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells

Article

Published on 2021-02-022022-10-30
Journal: Non-Coding RNA [Category] COVID-19,

ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients

중환자실 COVID-19 환자의 사망률 예측인자로서의 내피 바이오마커의 ICU 입원 수준

Observational Study

Published on 2021-01-192022-09-11
Journal: Cells [Category] MERS, 바이오마커, 임상,

[키워드] Adhesion Molecule Admission Ang-1 angiopoietin association Biomarker Biomarkers characteristic Cohort COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients determine died E-selectin elevated endothelial endothelial damage endothelial marker Endothelial markers endotheliopathy greater growth factor hospitalized patients ICU ICU admission Ill intensive care intensive care unit intercellular intercellular adhesion molecule involved Kaplan–Meier analysis Level marker Mortality non-survivor observational study predict Probability Prognostic value receiver operating characteristic ROC ROC Curve sE-selectin selectin sICAM-1 significantly sP-selectin suggested survival survivor Survivors Vascular vascular endothelial growth factor VEGF von Willebrand factor was used were assessed were measured
[DOI] 10.3390/cells10010186 PMC 바로가기 [Article Type] Observational Study

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험

Controlled Clinical Trial

Published on 2021-01-012022-09-11
Journal: Cell transplantation [Category] 유전자 메커니즘, 임상,

[키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF
[DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial

Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV-2 Infection Severity

니코틴은 기도 상피 표현형을 변화시키고 SARS-COV-2 감염 심각도를 증가시킬 수 있습니다

Article

Published on 2020-12-282022-09-12
Journal: Molecules [Category] MERS, SARS, 진단,

Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection

Cell and Developmental Biology

Published on 2020-12-182022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing
[DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology

System biological investigations of hydroxychloroquine and azithromycin targets and their implications in QT interval prolongation

Article

Published on 2020-12-012022-10-04
Journal: Chemico-biological interactions [Category] SARS, 신약개발,

Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19

코로나바이러스감염증-19(COVID-19) 전 몇 주 동안 최적의 수분 공급이 COVID-19로 인한 사망의 위험 요소라는 가설

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 receptors active transport airway airways aldosterone angiotensin angiotensin converting enzyme AQP5 aquaporin Attention balance body water capillary leakage chronic chronic disease Chronic hydration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 mortality COVID-19 testing drinking water Drinking water intervention Effect endothelial enzyme epidemiological epithelial cells Evidence exaggerated immune response exposure to favor greater growth factor Hydration Hypertonicity hypothese hypotheses Hypovolemia increase Infection intake kinase likelihood limit lung lung epithelial cell Lung epithelial cells Male sex mechanism Mortality Older age pathway Pathways positive public health receptor recommendation reduce reduced risk factor Risk factors risk of COVID-19 risk reduction Saliva osmolality SGK1 Signaling TNF-alpha total body total body water Transport Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Vascular vascular endothelial growth factor VEGF VEGF. Via water Water balance
[DOI] 10.1016/j.mehy.2020.110237 PMC 바로가기 [Article Type] Article

Old Player-New Tricks: Non Angiogenic Effects of the VEGF/VEGFR Pathway in Cancer

Review

Published on 2020-10-272023-08-30
Journal: Cancers [Category] E형 간염,

[키워드] Angiogenesis anti-angiogenesis anti-angiogenic agents combination therapy Immune-checkpoint inhibitors Immunosuppression Immunotherapy tumor progression VEGF VEGFR
[DOI] 10.3390/cancers12113145 PMC 바로가기 [Article Type] Review

Stem cell therapy for COVID‐19, ARDS and pulmonary fibrosis

Review

Published on 2020-10-242022-10-31
Journal: Cell Proliferation [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory distress acute respiratory syndrome alveolar epithelial cell ARDS cause caused Cell clinical trial clinical trials coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CRS Cytokine release syndrome Cytokines derivative Efficacy endothelial Exosomes Factor Factors FGF fibroblast function growth hearts HGF illnesses immune cells immune system KGF lung Mesenchymal stem cells MSC MSCs MSCs therapy Necrosis other organ paracrine Pathogenesis pathogenic Patient potential mechanism Potential treatment preclinical studies preclinical study progression promote PROTECT Protein pulmonary fibrosis quantified Registered regulate respiratory infectious disease SARS‐CoV‐2 secrete secreting secretion shown stem cell Stem cell therapy suggested supportive care syndrome the disease therapeutic therapeutic potential therapy tissue repair TNF‐α Treatment variety Vascular VEGF
[DOI] 10.1111/cpr.12939 PMC 바로가기 [Article Type] Review

Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology

Research

Published on 2020-10-162022-10-28
Journal: BioData Mining [Category] COVID-19,

[키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing
[DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research