viral spike – Page 6 – Communicable Diseases Research

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Antiviral Agents

Published on 2021-09-202022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19,

Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Research Article

Published on 2021-09-082022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 glycoprotein ACE2 receptor ACE2-spike binding addition antiviral therapy approach binding biological activities Cell cell entry receptor cell membrane coronavirus Critical demonstrated disrupt Endoplasmic reticulum enzyme examined expression function glycosylation hACE2 Human human ACE2 illness implicated Infection Interaction Mutagenesis N-glycan N-glycosylation N-linked glycan not affected offer property Protein Pseudotyped viruses receptor recruitment reduced reducing required role S proteins SARS Coronavirus SARS-CoV SARS-CoV S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 S protein subsequent Support surface susceptibility syncytium formation transmembrane glycoprotein Treatment type I understanding viral entry viral spike virus entry
[DOI] 10.1128/Spectrum.01199-21 PMC 바로가기 [Article Type] Research Article

Neutralizing antibodies for the prevention and treatment of COVID-19

코로나19 예방 및 치료를 위한 중화항체

Review

Published on 2021-09-082022-09-11
Journal: Cellular and Molecular Immunology [Category] SARS, 변종, 비임상, 신약개발, 임상, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 antibody binding binding affinity cellular receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 effective Efficiency focus followed by host cell Immunotherapy IMPROVE infection process information initiate membrane fusion monoclonal antibodies N-terminal domain NAb NAbs neutralization Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody Protein provide provided RBD Receptor-binding domain respiratory S protein S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S protein SARS-CoV-2 strains SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 therapeutic target Treatment treatment of COVID-19 Viral viral infection viral spike virus entry
[DOI] 10.1038/s41423-021-00752-2 PMC 바로가기 [Article Type] Review

The structural basis of accelerated host cell entry by SARS-CoV-2†

SARS-CoV-2에 의한 가속화된 숙주 세포 진입의 구조적 기초†

Article

Published on 2021-09-012022-09-11
Journal: The Febs Journal [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] accelerate accelerated ACE-2 ACE2-RBD acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Antiviral strategies antiviral strategy base C-terminal domain causative agent cell entry cellular entry cleavage site conserved Contact contagious contribute coronavirus Coronavirus disease 2019 COVID-19 disease domain effective entry receptor enzyme epithelial epithelium exhibit explain faster Features flat furin furin protease HCoVs high-affinity binding host cell human coronavirus hypothese Interaction leads Mutation N-terminal domain notable NTD other proteases pandemic pandemic coronavirus Proteases Protein protein-protein interaction RBD receptor Receptor-binding domain respiratory respiratory epithelia S protein S1 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sialic acid sialic acid-binding domain. Spike protein subunit the receptor-binding domain the S protein the S1 subunit the spike protein Tight binding turn Viral viral RBD viral S viral spike
[DOI] 10.1111/febs.15651 PMC 바로가기 [Article Type] Article

Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteins

Research article

Published on 2021-09-012022-10-05
Journal: Bioresource Technology Reports [Category] 신약개발,

[키워드] Analysis Antiviral binding binding energy COVID degrade docking drugs enzyme Enzymes Extracellular fungal identify in-silico infectious agents microbial Penicillium protease Protein repurposing resource selected tap the SARS-CoV-2 virus therapeutic therapeutic agent Viral protein viral spike
[DOI] 10.1016/j.biteb.2021.100756 [Article Type] Research article

Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor

Research

Published on 2021-08-302022-11-01
Journal: Cell & Bioscience [Category] COVID-19,

Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza

Molecular Biosciences

Published on 2021-08-302022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 activated Activation angiotensin-converting enzyme 2 Antiviral bind can be used cathepsin L cellular protease cleaved coronavirus COVID-19 effective vaccine enzyme FIVE furin help host cell host cells host protease host proteases human proteases indicate Influenza outlined pandemic pathway Pathways Potential provided receptor S glycoprotein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-S serine protease the S protein therapeutic agents Therapeutic approach therapeutic option therapeutic strategy therapeutic targets TMPRSS2 viral infection viral mutation viral S protein viral spike virus
[DOI] 10.3389/fmolb.2021.725528 PMC 바로가기 [Article Type] Molecular Biosciences

Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral Immunity

SARS-CoV-2 감염 중 COVID-19 증상의 발생은 체액 면역 약화를 정의합니다

Immunology

Published on 2021-08-162022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] age antibody Antibody Response Antibody responses Antigen Asymptomatic asymptomatic individual Asymptomatic individuals asymptomatic infections body weight both groups collective/herd immunity correlated COVID-19 COVID-19 patients declined detectable Endemic enrolled Humoral immunity IgG IgG antibodies IgG response IgG responses IgM IgM response IgM responses Immunity immunization Immunoglobulin Immunoglobulin G implication in both groups individual Infection mounted neutralizing capacity nucleoprotein occur Plasma level Plasma levels Prevalence question raising SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2-specific IgG Sex side specific IgG antibodies subsequent Surveillance symptomatic symptomatic and asymptomatic symptomatic patient Symptomatic patients Symptoms the SARS-CoV-2 Viral viral spike Wuhan Wuhan, China
[DOI] 10.3389/fimmu.2021.722027 PMC 바로가기 [Article Type] Immunology

Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools

컴퓨터 도구를 사용한 SARS-CoV-2 바이러스 단백질에 대한 식물 유래 화합물의 가상 스크리닝

Article

Published on 2021-08-102022-09-11
Journal: The Science of the total environment [Category] SARS, 치료제,

[키워드] 3-chymotrypsin-like protease addition amyrin antiviral activity Atazanavir AutoDock binding Chloroquine chymotrypsin Chymotrypsin-like protease Compound computational tool Control COVID-19 COVID-19 pandemic delphinidin dicumarol docking Docking studies drug evaluate evaluated explain glycoprotein Glycyrrhetinic acid glycyrrhizin highest affinity host cell host cells hydrogen Hydrogen bond hydrophobic hydrophobic interaction hydrophobic interactions Hydroxychloroquine identify in viral inhibitor Interaction involved lowest M pro molecular molecular docking molecular target nelfinavir new SARS-CoV-2 plants protease Protein Proteins public health Recognition Replication responsible S protein SARS-CoV-2 SARS-CoV-2 viral SARS-CoV2 spike spike glycoprotein taraxasterol target umifenovir Viral protein Viral proteins viral replication viral spike virus was performed were used
[DOI] 10.1016/j.scitotenv.2021.146400 PMC 바로가기 [Article Type] Article

Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease Progression

Article

Published on 2021-08-092022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

[키워드] age anti-SARS-CoV-2 antibody Cellular and humoral immunity Cellular immune response Cohort concerning convalescent COVID-19 detectable domain Donor donors elderly elevated ELISA assay Epitopes equipment evaluate evidence of flow cytometry healthy controls humoral Humoral immunity IFN-γ Immune cell Immunity individuals interferon-γ knowledge Laboratory leucocyte long-lasting membrane Mild Moderate COVID-19 Multiplex assay natural killer cell NK-cells no difference nucleocapsid protein performed persistence post infection previous study provide SARS-CoV-2 SARS-CoV-2-specific peptides significantly specimen subpopulations viral spike while
[DOI] 10.3390/life11080805 PMC 바로가기 [Article Type] Article