Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)Short Communication Published on 2021-01-052022-11-01 Journal: Virus research [Category] COVID-19, MERS, SARS, [키워드] Cell coronavirus disease Course COVID-19 COVID-19 patient COVID-19 severity decrease defined expressed expression Genes healthy controls IFN IFN alpha/beta IFN lambda IFNs Innate immunity interferon Invasive mechanical ventilation IRF7 ISG ISGs Oropharyngeal Patient required respiratory tract SARS-CoV-2 SARS-CoV-2 positive patient stimulated type I upper respiratory tract [DOI] 10.1016/j.virusres.2020.198283 PMC 바로가기 [Article Type] Short Communication
Polycations and polyanions in SARS-CoV-2 infectionSARS-CoV-2 감염의 다중양이온 및 다중음이온Review Published on 2021-01-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] Adding administration aggravate Cell cell membrane conjunction COVID-19 cytokine Cytokines cytotoxicity Effect electrostatic repulsion heparin heparins Histones Innate immunity neutrophil Neutrophils nuclear opsonin oxidants polyanions Polycations pro-inflammatory released SARS-CoV-2 SARS-COV-2 infection secreted the cell therapy virus particle virus particles [DOI] 10.1016/j.mehy.2020.110470 PMC 바로가기 [Article Type] Review
Detection of Viral Infections by Innate ImmunityReview Published on 2021-01-012023-07-11 Journal: Biochemical pharmacology [Category] SARS, [키워드] cGAS. COVID-19 DNA sensors IFI16 inflammasomes Innate immunity interferon Pattern recognition receptors pro-inflammatory cytokines RIG-like receptors SARS-CoV-2 STING Toll-like receptors virus [DOI] 10.1016/j.bcp.2020.114316 [Article Type] Review
Fasciola hepatica induces weak NETosis and low production of intra- and extracellular ROS in exposed bovine polymorphonuclear neutrophilsArticle Published on 2021-01-012023-06-22 Journal: Developmental and comparative immunology [Category] 조류인플루엔자, [키워드] Fasciola hepatica Innate immunity NETosis Neutrophil extracellular traps ROS. [DOI] 10.1016/j.dci.2020.103787
Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sexCOVID-19의 사이토카인 방출 증후군: 선천성 면역, 혈관 및 혈소판 병원성 요인은 질병의 중증도와 성별이 다릅니다.Clinical Trial Published on 2021-01-012022-09-25 Journal: Journal of leukocyte biology [Category] SARS, 바이오마커, 임상, 진단, [키워드] Activation acute illness addition age Analysis analyzed association Biomarker CD40L Characteristics clinical feature Clinical features Cluster Cohort controls COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines disease disease pathology disease severity examined Factor females FGF fibroblast fibroblast growth factor growth Growth factors Health Health crisis highlight Hospitalized ICU admission identify IL-13 IL-4 immune immune response immune responses Immunopathogenesis Inflammatory cytokines Innate Innate immunity IP10 male pathogenic Patient PDGF Plasma cytokine Platelet platelet-derived growth factors Protein public health crisis risk severe disease Severity of disease Sex significant increases in syndrome Treatment understanding Vascular Vasculitis with COVID-19 [DOI] 10.1002/JLB.3COVA0820-410RRR PMC 바로가기 [Article Type] Clinical Trial
COVID-19: disease, or no disease? – that is the question. It’s the dose stupid!Mini review Published on 2021-01-012022-10-05 Journal: Microbes and infection [Category] 유전자 메커니즘, [키워드] Affect consequence Course COVID-19 COVID-19 pandemic disease dose Effect galectins high variability infecting Infection Innate immunity outcome question raise raised threshold tissue virus [DOI] 10.1016/j.micinf.2021.104779 [Article Type] Mini review
SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsetsSARS-CoV-2 감염은 순환 단핵구에서 혼합 M1/M2 표현형을 유도하고 수지상 세포 및 단핵구 하위 집합 모두에서 변경을 유도합니다Clinical Trial Published on 2020-12-312022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] activated Activation adoptive immunity alteration Analysis B lymphocytes Cell center circulating monocyte clinical Clinical Center clinical manifestation clinical manifestations COVID-19 patient cytometric dendritic cell dendritic cells event expressed Flow Flow cytometric analysis functional highlight Immunity immunological indicated induce Innate immunity less low expression lymphocyte Lymphocytes M1 and M2 monocytes M2 marker M2 monocyte M2 monocytes marker Mild mild case mild cases Mild symptom mild symptoms monocyte Monocytes myeloid NK cell NK cells Patient Peripheral blood peripheral blood cell peripheral blood cells phenotype phenotypic preserved proportion recruited SARS-COV-2 infection severe cases severe disease severe symptom severity subset Symptom T and B lymphocytes the disease was performed [DOI] 10.1371/journal.pone.0241097 PMC 바로가기 [Article Type] Clinical Trial
The delicate balance between Entamoeba histolytica, mucus and microbiotaarticle Published on 2020-12-312024-09-01 Journal: Gut Microbes [Category] 세균성이질, [키워드] Bacteria Entamoeba histolytica Goblet cell Innate immunity Muc2 mucin mucosal epithelium Mucus pro-inflammatory cytokines secretion [Article Type] article
Mucin signature as a potential tool to predict susceptibility to COVID‐19COVID-19에 대한 감수성을 예측하는 잠재적 도구로서의 뮤신 시그니처Review Published on 2020-12-292022-09-10 Journal: Physiological Reports [Category] MERS, 유전자 메커니즘, 진단, [키워드] Asymptomatic Biomarker cells component Corona COVID‐19 COVID‐19 patients Critical cytokine Cytokines Economy expression glycome Health help highlight host cells identify individual individuals Infection Infectious disease Inflammation Innate immunity involved lead Measures Mild molecular mucin mucins new virus pandemic pathogenicity Pathogens pathology Patient predict progression Protein quarantine quarantine measures recent receptor receptors regulated respiratory response to therapy SARS‐CoV‐2 severe symptom severe symptoms susceptibility symptomatic the cells therapy upper respiratory tract virus viruses [DOI] 10.14814/phy2.14701 PMC 바로가기 [Article Type] Review
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 막(M) 단백질은 RIG-I/MDA-5 신호전달을 표적으로 하여 I형 및 III형 인터페론 생산을 억제합니다Article Published on 2020-12-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affected Antiviral antiviral immunity attenuate caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosolic ectopic expression ENhance evade facilitate IFN Immune suppression individuals Infection Infectious diseases inhibit Innate immunity interact interferon Interpretation IRF3 M protein MAVS mechanism membrane molecular mechanism multiprotein complex nuclear translocation pathogenic pathway Phosphorylation Protein provide Replication reported respiratory RIG-I SARS-CoV-2 SeV severe acute respiratory syndrome Coronavirus Signaling Spread stimulated stomatitis suppresse suppression TBK1 the SARS-CoV-2 TRAF3 type I type I and III IFNs vesicular stomatitis vesicular stomatitis virus Viral viral replication [DOI] 10.1038/s41392-020-00438-7 PMC 바로가기 [Article Type] Article