COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
COVID-19 가상 환자 코호트는 질병 결과를 주도하는 면역 메커니즘을 제안합니다
Research Article
[키워드] accelerated
Analysis
approach
Biomarker
Biomarkers
calibrated
CD8
clinically
Cohort
Concentration
COVID-19
Critical
diagnostic
disease
Diversity
driver
Drivers
driving
expand
experimental model
experimental models
feature
identifying
IFN
IL-6
immune mechanism
immune response
immune responses
immunological
immunopathology
in silico
individual
infected cell
Inflammation
inflammatory disease
Intervention
lead
Longitudinal data
Macrophage
mathematical
mathematical model
maximum concentration
outcome
pathogen
Pathogens
Patient
patient cohort
patients
Phenotypes
predicted
production rates
reduced
reducing
regulate
responses
robust
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 infections
severe COVID-19
Support
T cell
T cell depletion
therapeutic targets
treatment approaches
Type I IFN
understanding
[DOI] 10.1371/journal.ppat.1009753 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009753 PMC 바로가기 [Article Type] Research Article