responses – Page 67 – Communicable Diseases Research

A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques

새로운 DNA 및 단백질 조합 COVID-19 백신 제형은 붉은털 원숭이에서 SARS-CoV-2에 대한 완전한 보호를 제공합니다

Coronaviruses

Published on 2021-03-012022-09-12
Journal: Emerging Microbes & Infections [Category] SARS, 진단,

Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system

1차 인간 기도 시스템에서 합성 STING 효능제에 의한 코로나바이러스 감염 억제

Article

Published on 2021-03-012022-09-11
Journal: Antiviral Research [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] 229E Activation addition agonists Air-liquid interface airway anti-coronavirus activity antiviral activity apical surface approved autophagy caused cell culture systems clinically common cold coronavirus Coronavirus infection Coronavirus infections COVID-19 cultures Defense defense mechanisms demonstrated dependent on diABZI. dimeric effective elicit epithelial fibroblast HCoV HCoV-229E highly pathogenic Host host defense human coronavirus human coronavirus 229E human coronaviruses Infection inhibition inhibitory effect initiated interferon interferon pathway International investigated low-dose lung cell mechanism Medicine microbial microbial infections other coronavirus other coronaviruses outbreak Pathogens pathway Pneumonia Prevent prevented primary human airway public health emergency receptor reduced Remdesivir responses SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus small molecule Spread stimulator STING STING agonist the interferon the SARS-CoV-2 therapeutic potential treat Treatment triggered type I interferon unmet need Viral load
[DOI] 10.1016/j.antiviral.2021.105015 PMC 바로가기 [Article Type] Article

Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses

Article

Published on 2021-02-262022-10-04
Journal: Scientific Reports [Category] MERS, 진단,

Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

인간의 급성 SARS-CoV-2 감염에 대한 항체 반응의 범위와 기능

Research Article

Published on 2021-02-262022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, 진단, 치료법,

[키워드] ACE2 ACE2-blocking response acute SARS-CoV-2 infection acute viral infection analysed anti-non-RBD S1 Anti-RBD antibodies Anti-RBD antibody Anti-RBD MAb Anti-RBD MAbs anti-receptor-binding domain anti-S2 Anti-spike anti-spike MAbs antibody Antibody Response Antibody responses Antibody-mediated immunity average Betacoronavirus binding blockade blocked clone Clusters combinations Complete COVID-19 outbreak COVID-19 patient cross-react elicited epitope Epitopes expansion Fever FIVE glycoprotein Health Human human coronavirus human coronavirus OC43 humans Humoral response IgG Immunity independent assays mAbs memory B cell memory B cells monoclonal antibody neutralise neutralising Neutralising activity Neutralising Antibodies neutralising antibody neutralising antibody response non-overlapping epitope non-overlapping epitopes non-RBD S1 nucleocapsid offer outbreak Patient peripheral plasmablast response plasmablast plasmablast response plasmablast responses potent Prolonged fever Prophylactic RBD reactive Receptor-binding domain recovered patient Region responses SARS-CoV-2 SARS-COV-2 infection separate cluster sera serological Serological and plasmablast responses serology somatic mutations spike glycoprotein subset tested the RBD the receptor-binding domain therapeutic agent therapeutic agents titre Viral viral infection Virus spike wild-type SARS-CoV-2
[DOI] 10.1371/journal.ppat.1009352 PMC 바로가기 [Article Type] Research Article

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG는 외피 바이러스 반응을 특성화하고 COVID-19 심각성과 상관 관계가 있습니다.

Research Article

Published on 2021-02-262022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단,

[키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADCC amplify amplifying anti–SARS-CoV-2 IgG antibody antibody-dependent cellular cytotoxicity anticancer Antigen antigens Antiviral association Attenuated Virus B cell B cell response binding Blood blood cell Blood cells Blood Group C-reactive protein C-reactive protein (CRP cause Cell cellular circumvent Clinical outcome complement Concentration condition conserved coronavirus COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients cytokine Cytokine storm dengue virus destruction determined by disparate domain domains elevated Exacerbation example excessive inflammation Fc receptor Fc receptors FcγRIIIa foreign antigen foreign antigens fucose functions glycoprotein Glycoproteins glycosylation help hepatitis B Hepatitis B virus HIV host cell host cells humans Hypothesis IgG IgG antibody IgG immune response IgG response IgG responses IL-6 Immune cell immune response immune responses Immune-mediated Immunoglobulin Immunoglobulin G in some in vitro individual individuals induce initiate interleukin-6 invading pathogens investigated isotype Macrophage macrophages membrane Mild disease mild symptoms mRNA vaccines myeloid cells natural infection natural killer occur over Pathogens Pathologies pathology Patient patients plasma position proinflammatory Proinflammatory cytokine promote promoted Protective Protein Protein subunit receptor receptors Region report reported required respiratory response responses responses against SARS-CoV-2 Science Seroconversion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe symptom severe symptoms severity strength subclass subunit sugar surface protein target target cell target cells tested therapeutic therapeutic antibodies Treatment Trigger vaccination Vaccinations Vaccine variant Viral Viral load virus viruses with COVID-19 with mild disease
[DOI] 10.1126/science.abc8378 PMC 바로가기 [Article Type] Research Article

Repurposing of Sitagliptin- Melittin Optimized Nanoformula against SARS-CoV-2; Antiviral Screening and Molecular Docking Studies

Article

Published on 2021-02-262022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Clinician Perspectives of COVID-19-Related Cancer Drug Funding Measures in Ontario

Article

Published on 2021-02-262022-10-31
Journal: Current Oncology [Category] COVID-19, MERS,

Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients

Article

Published on 2021-02-252022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS,

Nature’s Role in Supporting Health during the COVID-19 Pandemic: A Geospatial and Socioecological Study

Article

Published on 2021-02-242022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS,

SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection

초기 비인두 감염에서 SARS-CoV-2 선천적 이펙터 연관성 및 바이러스 부하

Observational Study

Published on 2021-02-242022-09-01
Journal: Physiological Reports [Category] MERS, 임상, 진단,

[키워드] 95% CI ACE age ambulatory Antiviral antiviral gene antiviral protein antiviral responses applied association Biomarkers blocked BST cause Chain Reaction change characterized clinical outcomes clinical testing COVID‐19 cytokine Cytokines discrepancy disease disrupt early disease Effects elevated Evidence evidence of examined Host host shut‐off Hypothesis IFIT1 IFIT3 IFN IFN‐γ immune immune responses immunoassays individual Infection Inflammatory cytokines innate immune innate immune response innate immune responses Innate immunity interferon interferons ISG Modification multiplex nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Older age outcomes Patient polymerase chain polymerase chain reaction polymerase chain reaction assays Proinflammatory cytokine Protein proteomics Quantitative responses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease subsequent Symptom symptomatic patient systemic inflammatory tested transcribed transcript Transcription transcripts translated translation university Utah Viral viral infection Viral load widespread with infection
[DOI] 10.14814/phy2.14761 PMC 바로가기 [Article Type] Observational Study