sera – Page 69 – Communicable Diseases Research

COVID-19 and Hyperimmune sera: A feasible plan B to fight against coronavirus

Review

Published on 2020-11-202022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

Performance of the COVID19SEROSpeed IgM/IgG Rapid Test, an Immunochromatographic Assay for the Diagnosis of SARS-CoV-2 Infection: a Multicenter European Study

SARS-CoV-2 감염 진단을 위한 면역 크로마토그래피 분석인 COVID19SEROSpeed IgM/IgG Rapid Test의 성능: 다기관 유럽 연구

Multicenter Study

Published on 2020-11-202022-09-10
Journal: Journal of Clinical Microbiology [Category] 진단, 치료기술,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody antibody assay Antibody Response Autoimmune disorders chemiluminescence immunoassay clinical sensitivity clinical specificity Cohen’s kappa coefficient Concordance coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated diagnosis of SARS-CoV-2 diagnostic disease early stage early stages Efficiency enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay European evaluated exhibited FIVE highest IgM and IgG IgM/IgG immunoassay immunochromatographic assay Infection Kappa coefficient Kinetics multicenter N proteins New coronavirus overall concordance pandemic Paris Pasteur Institute Patient patients performance positive post-symptom onset presence of antibody PSO qRT-PCR Quantitative Rapid Rapid test respiratory reverse transcription-PCR SARS-CoV-2 SARS-COV-2 infection sera serology Seven severe acute respiratory syndrome Coronavirus specificity specimen specimens Symptomatic patients Test tested the antibody response the disease Viral viral infection viral infections
[DOI] 10.1128/JCM.02240-20 PMC 바로가기 [Article Type] Multicenter Study

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

Article

Published on 2020-11-182022-10-04
Journal: Scientific Reports [Category] 변종, 치료기술,

[키워드] addition Administered adverse effect aluminum applied candidate vaccine Combination COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 vaccine CpG cross-neutralize cytokine D614G variant development dominant elicited ENhance health emergency hydroxide immunized immunized mice immunology immunopathology lentivirus MERS-CoV mice Microbiology mitigate neutralizing antibody prefusion Prevent pseudotyped pseudovirus reporter S-2P SARS-CoV-2 spike antigen SARS-CoV-2 spike protein secreted sera splenocyte subunit Support Th1 the antibody the spike protein TLR9 Toll-like receptor Treatment two-dose regimen Vaccine was selected wild-type SARS-CoV-2
[DOI] 10.1038/s41598-020-77077-z PMC 바로가기 [Article Type] Article

COVID-19 Infection Detection and Prevention by SARS-CoV-2 Active Antigens: A Synthetic Vaccine Approach

Communication

Published on 2020-11-182022-10-28
Journal: Vaccines [Category] COVID-19,

Seroprevalence of SARS-CoV-2 IgG Antibodies in Corsica (France), April and June 2020

Article

Published on 2020-11-052022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

SARS-CoV-2 스파이크 대 핵단백질 항체 반응의 변화는 인구 기반 혈청 유병률 연구에서 감염 추정에 영향을 미칩니다

Pathogenesis and Immunity

Published on 2020-11-032022-09-10
Journal: Journal of Virology [Category] 진단, 치료법, 치료제,

[키워드] acute infection acute phase acute respiratory syndrome acute respiratory syndrome coronavirus anti-N antibodies anti-N antibody anti-S antibody anti-S IgG Antibody binding Antibody detection Antibody Response Antibody responses Antigen assays binding change characterization Cohort cohorts conformational coronavirus Critical enrolled epitope Epitopes estimate evaluate evaluated General population generate greater Impact individual Infection Luminex assay monomer monomeric N protein N protein assay nucleocapsid nucleoprotein Patient population study Postinfection Protein ranged reduction in respiratory response responses responses against S protein S protein trimer S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sera Serological assay serology Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly more spike subjects Switzerland the antibody response the N protein the S protein trimer trimeric trimeric S protein vaccine-induced antibody response viral S was reduced
[DOI] 10.1128/JVI.01828-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods

경미한 영향을 받은 COVID-19 회복기 환자의 낮은 혈청 중화 항-SARS-CoV-2 S 항체 수준이 두 가지 다른 검출 방법으로 밝혀짐

Article

Published on 2020-11-022022-09-11
Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 진단, 치료기술, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-SARS-CoV-2 S anti-SARS-CoV-2 S1 IgG antibodies antibody binding biosafety Cell clinical symptom Clinical symptoms convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated correlated strongly COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients Donor ELISA enzyme faster IgA antibodies Infection interfere less Neutralization assay neutralization test Neutralizing Neutralizing antibodies neutralizing antibody passive antibody therapy Patient patient age plasma Predictive markers Prevalence RBD Receptor-binding domain respiratory S protein S1 IgG SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike sera serum serum antibodies serum antibody severe acute respiratory syndrome Coronavirus severity stomatitis surrogate virus neutralization test sVNT the receptor-binding domain the SARS-CoV-2 vesicular stomatitis vesicular stomatitis virus viral infection virus neutralization test VSV
[DOI] 10.1038/s41423-020-00573-9 PMC 바로가기 [Article Type] Article

Validation and clinical evaluation of a SARS-CoV-2 surrogate virus neutralisation test (sVNT)

Research Article

Published on 2020-11-012022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS,

[키워드] analytical sensitivity anti-SARS-CoV-2 antibody biosafety can be used cell-based virus neutralisation assay clinical clinical evaluation clinical sensitivity collected COVID-19 described detect determine Diagnosis ELISA functional Immune status increase in independent infection assay natural infection neutralisation neutralisation assay neutralisation assays Neutralising Antibodies PCR-confirmed COVID-19 performed positive Pseudotyped viruses pseudovirus neutralisation assay Receptor binding domain SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralising antibody sensitivity sera severity specificity surrogate virus neutralisation assay sVNT symptom onset titre vaccinated individual vaccination validation Virus neutralisation virus neutralising assay wild type
[DOI] 10.1080/22221751.2020.1835448 PMC 바로가기 [Article Type] Research Article

Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA

Article

Published on 2020-10-222022-10-04
Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술,

[키워드] absorbance value acute respiratory syndrome Affect Algorithms anti-SARS-CoV-2 IgG antibody Antibody detection Asymptomatic asymptomatic subject caused collected Contact Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 patient demonstrated detect detection detection rate development Diagnosis disease ELISA healthy donor IgG IgG antibody IgG ELISA IgG response inactivated Inactivated virus Infection OD value pandemic Patient populations positive proportion Result SARS-CoV-2 sera serologic serum/plasma severe disease severity significant difference specificity the patient utility Viral RNA was used with mild disease
[DOI] 10.1016/j.jviromet.2020.113996 PMC 바로가기 [Article Type] Article

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

Research

Published on 2020-10-222022-10-31
Journal: Eurosurveillance [Category] COVID-19, MERS, SARS,