Hospitalization requiring intensive care unit due to SARS-CoV-2 infection correlated with IgM depression and IgG elevationShort Communication Published on 2022-02-022022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] analyzed anti-Spike IgG antibody Antibody Response antibody response against biochemical blood sample Care clinical disease correlated COVID-19 Depression disease severity FIVE help hospital hospitalized patient hospitalized patients humoral ICU ICU admission IgG IgG level IgM Immunoglobulin immunology Infectious disease initial symptom intensive care investigated knowledge material Patient patients patients hospitalized positively correlated predict Protein SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection Spike protein symptom onset the spike protein viral membrane virus with COVID-19 [DOI] 10.2144/fsoa-2021-0126 PMC 바로가기 [Article Type] Short Communication
Differential Dynamics of SARS-CoV-2 Binding and Functional Antibodies upon BNT162b2 Vaccine: A 6-Month Follow-UpBNT162B2 백신에 대한 SARS-COV-2 결합 및 기능적 항체의 차등 역학 : 6 개월 추적 관찰Article Published on 2022-02-022022-09-01 Journal: Viruses [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, [키워드] anti-RBD Anti-RBD IgG anti-Spike IgG antibody association binding BNT162b2 characteristic collected comparable correlates of protection COVID-19 cutoff point decrease Definition demonstrated dose Dynamics functional high correlation Humoral response IgG indications Laboratory laboratory procedures lack less maturation mRNA NAb NAbs Neutralizing antibodies neutralizing antibody of BNT162b2 receiver operating characteristic receiver operating characteristic curve receiving resulting SARS-CoV-2 serum sample serum samples vaccination were measured WHO [DOI] 10.3390/v14020312 PMC 바로가기 [Article Type] Article
SARS-CoV-2 memory B and T cell profiles in mild COVID-19 convalescent patients경증 COVID-19 회복기 환자의 SARS-CoV-2 기억 B 및 T 세포 프로필Article Published on 2022-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive adaptive cellular immunity Analysis Anti-spike anti-Spike IgG cellular immunity convalescent Convalescents coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient cross-sectional declined demonstrated determined by disease onset ELISA ELISPOT evaluated first visit Frequency Humoral immunity IFN-γ IgG IL2 Immunity interferon gamma interleukin interleukin 2 long-lasting longitudinal longitudinal analysis longitudinal study magnitude MBC median memory B memory B cell memory B cells memory T cell memory T cells Mild Patient peptide peptide pools performed post infection profile RBD Receptor binding domain respiratory response SARS-CoV-2 SARS-CoV-2 anti-spike IgG SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Significant T cell T cells was determined [DOI] 10.1016/j.ijid.2021.12.309 PMC 바로가기 [Article Type] Article
Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare WorkersArticle Published on 2022-01-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered All participant Analysis anti-Spike IgG B cell baseline blood sample booster booster dose Cellular immune response cellular immunity ChAdOx1 ChAdOx1 nCoV-19 CoronaVac COVID-19 COVID-19 pandemic Decline dose early phase ELISA ELISPOT evaluate function healthcare healthcare worker humoral Humoral immunity IgG Immunity immunogenicity indicated neutralizing antibody PROTECT provided random SARS-CoV-2 significantly higher stratified T cell third dose Twenty participant vaccination Vaccine Vaccines were measured worker [DOI] 10.3390/vaccines10020217 PMC 바로가기 [Article Type] Article
Humoral response to the SARS-CoV-2 BNT162b2 mRNA vaccine: Real-world data from a large cohort of healthcare workersSARS-CoV-2 BNT162b2 mRNA 백신에 대한 체액 반응: 대규모 의료 종사자 집단의 실제 데이터Article Published on 2022-01-282022-09-12 Journal: Vaccine [Category] SARS, 진단, [키워드] accelerated age Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-Spike IgG antibody Blood BNT162b2 mRNA CMIA cohorts COVID-19 death determine elevated ENCODE Factor group groups healthcare healthcare worker humoral immune response Humoral immunity Humoral response IgG IgG antibody immune response immunological increase in independent large cohort median titer men Messenger RNA mRNA vaccine multivariate logistic regression participant pre-vaccination RBD real-world data Receptor binding domain reduction responsible S1 subunit SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 pandemic significantly Support susceptibility tested the SARS-CoV-2 the spike protein timepoints titer vaccination Vaccine Vaccines virus was collected women [DOI] 10.1016/j.vaccine.2021.12.014 PMC 바로가기 [Article Type] Article
Pharmacokinetics of high-titer anti–SARS-CoV-2 human convalescent plasma in high-risk children고위험 소아에서 고역가 항-SARS-CoV-2 인간 회복기 혈장의 약동학Clinical Trial Published on 2022-01-252022-09-12 Journal: JCI Insight [Category] 임상, 진단, [키워드] age Analysis Anti-spike anti-Spike IgG antibody antibody kinetics antibody production Antibody titer Antibody titers appear characterized children convalescent plasma coronavirus COVID-19 declined develop disease Donor ELISA assays enrolled epitope Euroimmun evaluated expected exposure to funding IgG immunoglobulins Infectious disease Kinetics Kinetics of antibodies median age Mild Mild disease neutralization capacity neutralization titer neutralizing capacity NIH passive transfer performed pharmacokinetic pharmacokinetics plasma PROTECT receive recipient Research Safe SARS-CoV-2 Serious Adverse Event Serious Adverse Events severe disease Spike protein symptom onset transferred transfused transfusion Trial registration underlying condition underlying conditions unlikely virus neutralization assays weight while [DOI] 10.1172/jci.insight.151518 PMC 바로가기 [Article Type] Clinical Trial
The Immune Response to SARS-CoV-2 Vaccination: Insights Learned From Adult Patients With Common Variable Immune DeficiencySARS-CoV-2 백신 접종에 대한 면역 반응: 공통 가변 면역 결핍증이 있는 성인 환자로부터 얻은 통찰력Immunology Published on 2022-01-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, [키워드] administration anti-SARS-CoV-2 anti-Spike IgG antibodies Antigen ATM Atypical B and T cells benefit binding classical cohorts common common variable immune deficiency convalescent COVID-19 CVID dose elicit elicited Frequency generate IgG response IgG responses immune response immune responses immunization immunize Infection Influenza Influenza virus insight MBCs mechanism memory B cell memory B cells monoclonal antibodies mRNA vaccine offered Patient patients positive potential benefit potential benefits produced Protein question Reinfection response SARS-CoV-2 SARS-COV-2 infection specific antibodies spike Spike protein spike-specific antibodies Spike-specific antibody subjects subsequent susceptibility T cell T cells T-cells T-cells response vaccinated individuals vaccination Vaccine variable Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2021.815404 PMC 바로가기 [Article Type] Immunology
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer암 환자에서 COVID-19 백신에 대한 면역 반응 약화를 증가시키는 부스터 용량의 효능Article Published on 2022-01-102022-09-12 Journal: Cancer cell [Category] MERS, SARS, 진단, 치료기술, [키워드] anti-Spike IgG booster booster dose COVID-19 vaccine Efficacy immune response Immunity inhibitor Patients with cancer Prospective clinical trial reduced seroconverted seronegative patient significant increases in therapy vaccination Vaccine were assessed [DOI] 10.1016/j.ccell.2021.11.006 PMC 바로가기 [Article Type] Article
Immunogenicity of SARS-CoV-2 vaccination in rituximab-treated patients: Effect of timing and immunologic parameters리툭시맙 치료 환자에서 SARS-CoV-2 백신 접종의 면역원성: 시기 및 면역학적 매개변수의 영향Article Published on 2022-01-012022-09-12 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 anti-Spike IgG antibody asked Autoimmune diseases B cell B cells Characteristics correlated COVID-19 Effect Hypogammaglobulinemia IgG IgM immune immune response immune system immunogenicity impair median time medications parameter Patient pre-vaccination recruited reduce reduced respond responses Rheumatic diseases rituximab RTX SARS-CoV-2 vaccination shown significantly therapeutic option therapy titers of IgG treated patient vaccination Vaccines [DOI] 10.1016/j.clim.2021.108897 PMC 바로가기 [Article Type] Article
Successful Elimination of SARS-CoV-2 Following Vaccination with BNT162b2 after Prolonged Viral Infection in an Immunocompromised Lymphoma PatientArticle Published on 2022-01-012022-11-15 Journal: Internal medicine (Tokyo, Japan) [Category] SARS, 진단, [키워드] acute respiratory syndrome Administered Anti-spike anti-Spike IgG antibody Bendamustine blood cell count BNT162b2 cellular cellular immunity coronavirus elevated eliminated Elimination humoral Infection Lymphocyte count lymphoma mantle cell Prolonged Prolonged infection SARS-CoV-2 suggested treated vaccination Vaccine virus [DOI] 10.2169/internalmedicine.9513-22 PMC 바로가기