Mesenchymal Stem Cells (MSCs) as a Potential Therapeutic Strategy in COVID-19 Patients: Literature ResearchCell and Developmental Biology Published on 2020-11-192022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] anti-inflammatory activity ARDS Biology cell-based therapies Cell-based therapy Characteristics China coronavirus COVID-19 COVID-19 disease COVID-19 patients Critical Critical case Cytokine storm dimension effective therapy Engineering Health literature lung Medicine mesenchymal stem cell Mesenchymal stem cells MSC MSCs outbreak outcome pandemic Pathologies Pneumonia positive Potential Pulmonary edema pulmonary inflammation raised reported representing respiratory responsible SARS-CoV-2 Secretome shown specific treatment STEM Strategy Symptoms symptoms of COVID-19 therapeutic potential therapeutic strategy these cell Treatment Vaccine were used [DOI] 10.3389/fcell.2020.602647 PMC 바로가기 [Article Type] Cell and Developmental Biology
Epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers in Hubei Province, ChinaOriginal Article Published on 2020-11-182022-10-30 Journal: Infection Control and Hospital Epidemiology [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval Analysis Asymptomatic case asymptomatic infections center Characteristics China Clinical characteristics cohort study confounder Contact Control coronavirus disease cough COVID-19 Critical case critical cases death died disease onset epidemiological evaluate Fatality rate fatigue groups HCW HCWs healthcare worker Infection laboratory-confirmed lower risk myalgia outbreak participant Patient prevention proportion reported Respiratory Coronavirus risk of death SARS-CoV-2 shown Symptom virus with COVID-19 [DOI] 10.1017/ice.2020.1321 PMC 바로가기 [Article Type] Original Article
Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysisResearch Published on 2020-11-162022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] 95% CI assessment AUC China Clinical practice clinician CNKI Coronavirus disease 2019 COVID-19 Critical case database diagnosed disease severity effective eligible evaluate Evaluating global public health help identify Infection Infectious disease Infrastructure management Meta-analysis Methodological quality mild patients Mortality Neutrophil-to-lymphocyte ratio NLR overall mortality Patient patients patients with COVID-19 performed poor prognosis Predictive Predictive value PROSPERO database QUADAS-2 Quality reduce Registered Registration reported Result screened searched sensitivity Severe case Severe patient specificity systematic review Treatment [DOI] 10.1186/s13054-020-03374-8 PMC 바로가기 [Article Type] Research
In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesisResearch Article Published on 2020-11-112022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract AKT1 Analysis approach ARDS Cancer candidate cascades Cell changes Coagulation coagulation cascade complement Complication computational analysis COVID-19 Critical Critical case Cytokines storm degranulation degree downstream driver expression Fold change Gene ontology globe host proteins Huh7 IFN-I in silico in vitro in vitro study include Infection inhibit intravascular coagulation IRAK1 IRF3 IRF7 ISG ITGAM KEGG pathway analysis knowledge lack MAPK signaling MAPK1 MAPK1/MAPK3 MAPK3 MAVS mechanism medical intervention mitigate MOST neutrophil degranulation overlap pathway Pathways PD-L1 platelet activation predicted Protein proteomic public health emergency receptor signaling Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 patients Signaling signaling pathway similarity Spread SRC STOM therapeutic targeting thrombosis thrombotic TNF TP53 Traf6 Transcriptome up-regulated VAMP8 viral infection viral pathogenesis [DOI] 10.1016/j.csbj.2020.11.005 PMC 바로가기 [Article Type] Research Article
Outcome of early-stage combination treatment with favipiravir and methylprednisolone for severe COVID-19 pneumonia: A report of 11 cases중증 코로나19 폐렴에 파비피라비르·메틸프레드니솔론 초기 병용치료 결과: 11건 보고Case Reports Published on 2020-11-012022-09-11 Journal: Respiratory investigation [Category] SARS, 치료법, 치료제, [키워드] Blood oxygen saturation Clinical outcome Combination combination treatment coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 pneumonia Critical case critical cases Favipiravir Health Organization indicated management Methylprednisolone novel Novel coronavirus novel coronavirus disease Novel coronavirus disease 2019 oxygen Oxygen administration oxygen supplementation Patient required room air Severe case severe cases severe COVID-19 Severe COVID-19 pneumonia severe illness steroid steroid therapy therapy treated Treatment use of corticosteroid ventilator World Health Organization [DOI] 10.1016/j.resinv.2020.08.001 PMC 바로가기 [Article Type] Case Reports
Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19COVID-19의 중증 및 중대한 사례의 임상 및 자가면역 특성Article Published on 2020-11-012022-09-12 Journal: Clinical and translational science [Category] MERS, SARS, 진단, [키워드] Admission analyzed antibody Autoimmune C-reactive protein caused Characteristics Chest computed tomography China clinical coronavirus coronavirus disease COVID-19 Critical Critical case critical cases disorder dominant elevated enrolled Fever ground-glass opacity immune dysfunction immunosuppressive intensive care interleukin-6 investigated kDa Laboratory laboratory characteristics laboratory data laboratory-confirmed lymphocytopenia men Novel coronavirus patchy Patient Pneumonia Prevalence SARS-CoV-2 Severe case subjects Symptoms therapy women [DOI] 10.1111/cts.12805 PMC 바로가기 [Article Type] Article
Clinical characteristics of “re-positive” discharged COVID-19 pneumonia patients in Wuhan, ChinaArticle Published on 2020-10-152022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] APACHE II blood pressure Characteristics chest CT scan chronic clinical Clinical characteristics Clinical symptoms collected common Comorbidities Confusion correlated COVID-19 COVID-19 patient COVID-19 pneumonia patient Critical case CURB-65 diagnosed discharge discharged Features Illness severity Laboratory results Medical research nucleic acid test Patient patients Physiology quarantine respiratory rate Risk factors RT-PCR Signs and symptoms subsequent Symptom urea Wuhan, China [DOI] 10.1038/s41598-020-74284-6 PMC 바로가기 [Article Type] Article
Epidemiological characteristics and the entire evolution of coronavirus disease 2019 in Wuhan, ChinaResearch Published on 2020-10-082022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, SARS, [키워드] Characteristics collected Community confirmed case coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 case Critical Critical case dead decrease died dropped epidemiological Epidemiological characteristics evaluate the effect Evolution Government incline individuals Infectious disease information Intervention Isolation lowest Mortality MOST National Non-pharmaceutical interventions occurred Older overall mortality proportion reported Result significantly Spread Surveillance Wuhan Wuhan, China [DOI] 10.1186/s12931-020-01525-7 PMC 바로가기 [Article Type] Research
Carcinoembryonic Antigen: A Potential Biomarker to Evaluate the Severity and Prognosis of COVID-19Medicine Published on 2020-10-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] adjusted age Analysis analyzed Antigen AUC Biomarker Carcinoembryonic antigen CEA characteristic Corona corona virus disease 2019 COVID-19 COVID-19 patient Cox regression model Critical case death death case death group discharged discharged patient discharged patients elevated ferritin level high mortality identification increased the risk intensive care Jin Logistic regression analysis medical intervention moderate Mortality pandemic disease Patient positive correlation Potential predict Prognosis radiologic Retrospective study risk of COVID-19 ROC ROC analysis serum severe acute respiratory coronavirus 2 severity and prognosis Sex significantly higher suggested survival with COVID-19 Wuhan [DOI] 10.3389/fmed.2020.579543 PMC 바로가기 [Article Type] Medicine
Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, ChinaResearch Article Published on 2020-10-052022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] abnormality Admission analyzed C-reactive protein Chest computed tomography China clinical Clinical characteristics Clinical data Clinical diagnosis Cluster Clusters common Comorbidities Comparative cough COVID-19 COVID-19 patient Critical Critical case cured D-dimer discharged elevated epidemiological fatigue females Fever Ground-glass opacities hospital investigated Laboratory Local lymphopenia male measure objective Older outbreak patchy pathogenicity Patient patients died prognosis of patient Questionnaires Red Result Severe patient severity Shortness of breath significantly Symptom the disease Transmission Treatment Wuhan Wuhan, China [DOI] 10.1155/2020/4783062 PMC 바로가기 [Article Type] Research Article