Simultaneous detection of SARS-CoV-2 and identification of spike D614G mutation using point-of-care real-time polymerase chain reaction현장 진료 실시간 중합효소 연쇄반응을 이용한 SARS-CoV-2 동시 검출 및 스파이크 D614G 돌연변이 식별Article Published on 2022-06-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applied Chain Reaction contagiousness coronavirus COVID-19 D614G D614G mutation detect Detection sensitivity detection system Diagnosis equipment high mortality Human labeling Laboratory Molecular diagnosis Multiple multiplex Mutation PCR platform POCT point-of-care polymerase chain polymerase chain reaction probe probes rapid detection method Real-time PCR respiratory virus respiratory viruses reverse transcription PCR rRT-PCR SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants Sensitivity and specificity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specificity spike Spike D614G mutation. strain was reduced wild type [DOI] 10.1016/j.jviromet.2022.114513 PMC 바로가기 [Article Type] Article
A screening strategy for identifying the dominant variant of SARS-COV-2 in the fifth peak of Kurdistan- Iran population using HRM and Probe-based RT-PCR assayHRM 및 프로브 기반 RT-PCR 분석을 사용하여 쿠르드-이란 인구의 다섯 번째 피크에서 SARS-COV-2의 우세한 변이를 식별하기 위한 스크리닝 전략Article Published on 2022-06-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 변종, [키워드] caused country D614G D614G mutation Del69-70 mutation diagnostic test dominant variant E484K E484K mutation E484Q mutation genomic Genomic surveillance high resolution HRM identify indicated Iran Kurdistan L452R L452R mutation melting mortality rate Mutation operation overlapped positive patient probe Probe-based RT-PCR reduce Resolution RT-PCR RT-PCR assay SARS CoV SARS CoV-2 SARS-CoV-2 positive patients screened screening strategy Sequencing suggested Surveillance T478K T478K mutation. Transmissibility variant variants whole-genome sequencing [DOI] 10.1016/j.jviromet.2022.114514 PMC 바로가기 [Article Type] Article
Heterogeneous SARS-CoV-2-Neutralizing Activities After Infection and Vaccination감염 및 예방 접종 후 이종 SARS-CoV-2-중화 활동Article Published on 2022-05-302022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed antibody Antibody Response Antibody responses best Beta Cohort coronavirus COVID-19 COVID-19 vaccination D614G declined decrease Delta dose exceeded greater heterogeneity Hospitalized hospitalized patient hospitalized patients Humoral immunity Immunity Improvements individual infected individual infected individuals infecting Infection lowest mRNA vaccine Mutation N-terminal domain neutralization neutralization titer neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody responses no difference not differ pandemic Patient patients Protein recognize respiratory SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-neutralizing antibodies SARS-CoV-2-specific antibody responses SARS-CoV-2-specific neutralizing antibodies second vaccination sequence serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly lower Specific specific neutralizing antibodies Spike protein symptom onset the SARS-CoV-2 the spike protein vaccinated individual vaccinated individuals Vaccine vaccinee vaccinees variants variants of concern viral strain viral strains virus infection VoC VOCs [DOI] 10.3389/fimmu.2022.888794 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection-Of Music and Mechanics of Its Spikes! A PerspectiveArticle Published on 2022-05-242022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 arising Biochemistry cellular Cobicistat coronavirus COVID-19 COVID-19 pandemic D614G darunavir Disulfide dorian Egmont endocytosis GSH GSSG hydrogen bonds Lipid rafts Lopinavir manifestation Mechanics mechanobiology music Pandemics peptide piezoelectricity produced Remdesivir Research Ritonavir SARS-CoV-2 spikes the SARS-CoV-2 virus Vaccine Vaccines virus virus propagation while [DOI] 10.1021/acsnano.1c11491 PMC 바로가기
Long-Lived Immunity in SARS-CoV-2-Recovered Children and Its Neutralizing Capacity Against OmicronSARS-CoV-2 회복 아동의 장기 면역 및 오미크론에 대한 중화 능력Article Published on 2022-05-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity Against antibody Antibody Response Antigen Asymptomatic Capacity CD4 T cell CD8 T cell CD8 T cells cellular immune responses children Cohort COVID-19 cross-neutralization D614G declined effectively controlled fold humoral Humoral and cellular immune responses immune immune memory immune responses Immunity IMPROVE induce Infection lack memory T cell memory T cells Mild neutralization neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody omicron pre-existing immunity pre-immune recall remained response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T cells seronegative T cell T cells vaccination Vaccine vaccine response variant variants variants of concern [DOI] 10.3389/fimmu.2022.882456 PMC 바로가기 [Article Type] Article
Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects백신 접종 대상체의 체액성 면역 프로파일링을 위한 SARS-CoV-2 변이 단백질 마이크로어레이 개발Article Published on 2022-05-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 anti-spike antibody antibody Antibody responses AZD1222 B.1.1.7 B.1.351 B.1.617 B.1.617.1 B.1.617.2 binding ChAdOx1 chimeric collected correlated D614G demonstrated develop development domain Drug development Extracellular globe host receptor Humoral immunity Humoral response humoral responses IgA IgG IgM isotype IgM isotypes immune inhibiting Microarray MONITOR mRNA-1273 mutant neutralization neutralizing activities Neutralizing activity neutralizing antibody P.1 platform Protein protein microarray Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serology serum spike variants subject the antibody response vaccinated individual vaccination Vaccine Vaccines variant variants variants of concern Virus neutralization wild-type [DOI] 10.1016/j.bios.2022.114067 PMC 바로가기 [Article Type] Article
Humoral Response to BNT162b2 Vaccine Against SARS-CoV-2 Variants Decays After Six MonthsSARS-CoV-2 변이체에 대한 BNT162b2 백신에 대한 체액 반응은 6개월 후 쇠퇴합니다.Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Against age age and gender Alpha Alter analyzed B.1 BNT162b2 BNT162b2 vaccine carried changes in Complete D614G decay decrease Delta determine Effectiveness evade evaluated Evidence FIVE Follow-up Gamma GraphPad humoral immune response immune escape mutation immune escape mutations immune response Immunity immunization immunogenicity individual men Month Neutralization assay Neutralizing Neutralizing activity Neutralizing antibodies neutralizing capacity Neutralizing titer Older participant plaque reduction neutralization Prospective Study protocols raised reduction response SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants serum serum sample serum samples severity shown Support titer titers Transmissibility vaccination Vaccine variant variants Viral viral variant Viral variants was measured [DOI] 10.3389/fimmu.2022.879036 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort studyCOVID-19에서 회복된 사람들의 감염 1년 후 SARS-CoV-2-특이 항체 및 T-세포 반응: 종단 코호트 연구Article Published on 2022-05-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Academy age analysed antibody Antibody Response antibody titres B.1.351 B.1.617.2 Beta Beta variant breadth caused center Chinese collected communicable disease Communicable Disease Diagnosis COVID-19 Critical cross-reactive cytokine cytokine profile D614G D614G variant delta variant Delta variants detect detectable discharged disease disease severity ELISA ELISPOT enrolled enzyme evaluated Follow-up Follow-up visit follow-up visits foundation humoral humoral and T-cell response ICS IFN-γ IFNγ IgA IgG antibodies IgG antibody IgM IL-2 immune immune response In-vitro individual individuals Infection initial interferon interferon γ interleukin interleukin-2 intracellular cytokine staining longitudinal cohort study magnitude Medical Research Council Medical Sciences memory memory immune response memory T-cell response memory T-cell responses microneutralisation assay natural Necrosis neutralising Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody titre neutralising antibody titres no difference not disrupted participant Patient patients patients with moderate PBMC PBMCs plasma plasma sample plasma samples Protein Receptor-binding domain recovered patient recovered patients recruited reduce reduced reducing reduction Reinfection remained retained robustness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 strain SARS-CoV-2 viral SARS-CoV-2-specific T-cell response Science severe disease spike Spike protein subset symptom severity Symptoms T-cell Response T-cell responses tested the interferon the receptor-binding domain the SARS-CoV-2 titre TNFα tumour necrosis factor Tumour Necrosis Factor α variant variants variants of concern Viral proteins viral strain viral strains Wuhan Wuhan, China [DOI] 10.1016/S2666-5247(22)00036-2 PMC 바로가기 [Article Type] Article
Potent Anti-SARS-CoV-2 Efficacy of COVID-19 Hyperimmune Globulin from Vaccine-Immunized Plasma백신 면역 혈장에서 COVID-19 과면역 글로불린의 강력한 Anti-SARS-CoV-2 효능Article Published on 2022-05-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin anti-SARS-CoV-2 Antiviral assessment assessments B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 BBIBP-CorV Beta block clinical trials convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hyperimmune globulin COVID-19 vaccine D614G Delta Effect effective Efficacy exhibit Gamma global public health Globulin hACE2 healthy donor healthy donors high-affinity binding human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hyperimmune hyperimmune globulin IFNAR Immunotherapy in vitro Injury lung N-terminal domain neutralization neutralization potency neutralization titer nucleocapsid nucleocapsid protein omicron Omicron variants P.1 Passive immunotherapy plasma potent Prophylactic Protein pseudotyped RBD RBD binding Receptor-binding domain reduced reduction in S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus significantly Sinopharm sinopharm COVID-19 vaccine. subsequent the receptor-binding domain the S protein Treatment variants variety viral loads weight loss [DOI] 10.1002/advs.202104333 PMC 바로가기 [Article Type] Article
Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patientsSARS-CoV-2 및 COVID-19 환자의 우려 변종에 대한 면역 회피 및 중화 항체 역가의 시간적 감소Article Published on 2022-05-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acquisition Alpha Beta Breakthrough infection breakthrough infections Chronological change concerning Course COVID-19 COVID-19 patient COVID-19 patients D614G decrease Delta delta variant disease severity ELISA enrolled examined Gamma Immune evasions Infection Neutralizing antibodies neutralizing antibody Neutralizing titer neutralizing titers prevalent strain problem SARS-CoV-2 strain Strains thought titers vaccination variant variants of concern variants of SARS-CoV-2 Variants strain. Wuhan Wuhan-Hu-1 [DOI] 10.1016/j.clim.2022.108999 PMC 바로가기 [Article Type] Article