DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines박테리아의 DNA 슈퍼코일링 차이는 폴리아민에 의한 이질적인 DNA 자이라제 활성화로 인해 발생합니다.Research Article Published on 2020-10-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation activity addition Alter Amino acid Bacteria bacterial species bacterial specy change changes in Concentration conserved Control determine discrepancies discrepancy disparate DNA DNA supercoiling E . coli enzyme Enzymes Escherichia coli Extracellular gyrase humans identify identity in vivo inhibit living cell mechanism metabolic conditions metabolic pathway metabolic pathways organism pathogen Pathogens pathway physiological polyamine polyamines precursor putrescine reducing reflect regulate regulated responsible Salmonella Signal transduction spermidine target topoisomerase [DOI] 10.1371/journal.pgen.1009085 PMC 바로가기 [Article Type] Research Article
Access and enrollment in safety net programs in the wake of COVID-19: A national cross-sectional surveyResearch Article Published on 2020-10-062022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] access added age Analysis applied calculated COVID-19 COVID-19 pandemic cross-sectional cross-sectional survey disparate economic devastation employment enrolled Enrollment Health identify Impact increase individual individuals individuals with COVID-19 Medicaid National oversampling pandemic question reduced reduction robust Seven significantly more [DOI] 10.1371/journal.pone.0240080 PMC 바로가기 [Article Type] Research Article
The Social Distancing Imposed To Contain COVID-19 Can Affect Our Microbiome: a Double-Edged Sword in Human HealthPerspective Published on 2020-09-162022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acting acute respiratory syndrome addition Antibiotic resistance Bacteria Bacterial bacterial diversity Can consequence coronavirus COVID-19 COVID-19 disease decrease Deleterious disparate Dysbiosis effective Health Host Human Infection intestinal measure microbial Microbiome microbiota New Oropharyngeal pandemic person-to-person transmission Prognosis progression pulmonary viral Research SARS-CoV-2 shown social distancing Spread Sword Transmission [DOI] 10.1128/mSphere.00716-20 PMC 바로가기 [Article Type] Perspective
The Health Opportunity Index: Understanding the Input to Disparate Health Outcomes in Vulnerable and High-Risk Census TractsArticle Published on 2020-08-102022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, [키워드] Analysis assist census Cincinnati Cleveland Community complex COVID-19 COVID-19 pandemic creating determine disease convergence disparate effective facilitated GIS Health Health disparities health equity health opportunity index highlight identify index influence input Intervention methodology Ohio opportunity outcome outcomes pandemic principal component analysis public health exposome risk social determinant social determinants of health synonymous thematic mapping tract understanding utility variable [DOI] 10.3390/ijerph17165767 PMC 바로가기 [Article Type] Article
Pathogenesis of COVID-19 from the Perspective of the Damage-Response FrameworkMinireview Published on 2020-07-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alter caused clinical manifestation Community coronavirus coronavirus disease COVID COVID-19 COVID-19 disease COVID-19 pathogenesis disease disparate explain flexible framework Host Immune-mediated manifestation mechanism microbial outcome pandemic Pathogenesis pathogenic Population potential therapy provide SARS-CoV-2 susceptibility viral pathogenesis virus [DOI] 10.1128/mBio.01175-20 PMC 바로가기 [Article Type] Minireview
A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis코로나바이러스 복제 소기관의 통합 구조 및 기능 모델: RNA 합성 추적Research Article Published on 2020-06-082022-08-13 Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] acute respiratory syndrome Analysis assortment autoradiography beta-CoV Cell cellular complex coronavirus Coronavirus replication CoV CoV infection CoV RNA-synthesizing machinery CoV RO CoVs disparate drug target element endomembrane endoplasmic reticulum membrane followed by functional induce infected cells Infection infections Infectious Bronchitis Virus international public health labeling membrane modifications membrane structures MERS-CoV metabolic Microscopy Middle East observation open organelle pan-CoV RO element pandemic Quantitative Replication respiratory responsible RNA synthesis SARS-CoV SARS-CoV-2 spherule thought Vesicle Viral viral replication Viral RNA viral RNA synthesis Zoonotic coronavirus [DOI] 10.1371/journal.pbio.3000715 PMC 바로가기 [Article Type] Research Article
Agile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health PlatformViewpoint Published on 2020-05-282022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Care Combination computational health coronavirus coronavirus disease COVID-19 Disease surveillance disparate Enabling Health health information Health information technology health system HIT identify information interface monitoring outbreak pandemic Pathogens Patient platform presenting provide public health real time real-time analytics real-world data respiratory tract infection Support Surveillance [DOI] 10.2196/18707 PMC 바로가기 [Article Type] Viewpoint
DC/L‐SIGNs of Hope in the COVID‐19 PandemicCOVID-19 팬데믹에서 희망의 DC/L-SIGNCommentary Published on 2020-05-062022-09-10 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] alveolar cell clinical observation copyright COVID‐19 dendritic cell disparate distal Effect endothelial cells explain explained Glycoproteins help Hope immune response immunopathology Interaction lung pandemic protein S receptor respiratory SARS Coronavirus SARS‐CoV‐2 Spike protein Spike Protein S [DOI] 10.1002/jmv.25980 PMC 바로가기 [Article Type] Commentary
The nucleoid occlusion protein SlmA is a direct transcriptional activator of chitobiose utilization in Vibrio choleraenucleoid occlusion protein SlmA는 Vibrio cholerae에서 키토비오스 활용의 직접적인 전사 활성제입니다.Research Article Published on 2017-07-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity addition aquatic environment bind Catabolism cause Cell cell division ChiS chitin chitobiose cholera cholerae composed Critical disaccharide disease disparate disrupt downstream drinking water Evolution expression function Gene regulation gene transfer horizontal gene Horizontal gene transfer identify implicated in vivo Interaction involved locus mechanism member mutant pathogen persistence Point mutation point mutations promoter Protein Proteins regulated Regulation regulator required TetR the marine transcriptional transcriptional activation transcriptional regulator transfer transposon utilization Vibrio cholerae water [DOI] 10.1371/journal.pgen.1006877 PMC 바로가기 [Article Type] Research Article
Extensive Copy-Number Variation of Young Genes across Stickleback Populations스틱백 개체군에 걸친 젊은 유전자의 광범위한 복사 수 변이Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive Analysis candidate Candidates category CNV CNV gene CNV genes CNVs Comparative genomics complexity copy-number variation copy-number variations disparate distribution duplicate gene Duplicate genes duplication duplications eco-genomic model ecological Effect elevated evaluate Evolution Extensive fixed Frequency function functional Genes Genetic genetic diversity Genome highlight identify individual Innovation interactions joint lineage-specific gene lineage-specific genes Local locus low frequencies molecular natural populations occur over Population population genomics population level populations prevalent producing selective pressure selective pressures Stage structural polymorphism subset teleost genome teleost genomes three-spined stickleback three-spined sticklebacks Variation whole genome sequence [DOI] 10.1371/journal.pgen.1004830 PMC 바로가기 [Article Type] Research Article