hACE2 – Page 7 – Communicable Diseases Research

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제

Article

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제,

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

단봉 낙타 나노바디는 SARS-CoV-2 변종을 광범위하게 중화시킵니다.

Article

Published on 2022-05-032022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antibodies antibody apex B.1.351 B.1.617.2 bind CDR3 complex structure conformational coronavirus CoV COVID-19 cryo cryo-EM Cryoelectron microscopy dose Dromedary dromedary camel nanobody VHH Epitopes expressing hACE2 heterodimer high affinity human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 humans involved MERS-CoV Middle East Middle East respiratory syndrome Middle East Respiratory Syndrome CoV nanobodies nanobody neutralization activity neutralize Neutralizing neutralizing antibody nonoverlapping epitope nonoverlapping epitopes platform Protein RBDs Receptor-binding domain receptor-binding domains recognize reservoir residue S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single-domain antibody syndrome target the RBD the S1 subunit therapeutic use transgenic mice transmitted trimer unique variant variants variants of concern viruses
[DOI] 10.1073/pnas.2201433119 PMC 바로가기 [Article Type] Article

Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid

SARS-CoV-2 Omicron SGp RBD와 인간 수용체 ACE2, 리모닌 및 글리시리진산의 상호작용에 대한 전산 연구

Article

Published on 2022-05-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종,

Potent Anti-SARS-CoV-2 Efficacy of COVID-19 Hyperimmune Globulin from Vaccine-Immunized Plasma

백신 면역 혈장에서 COVID-19 과면역 글로불린의 강력한 Anti-SARS-CoV-2 효능

Article

Published on 2022-05-012022-09-11
Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin anti-SARS-CoV-2 Antiviral assessment assessments B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 BBIBP-CorV Beta block clinical trials convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hyperimmune globulin COVID-19 vaccine D614G Delta Effect effective Efficacy exhibit Gamma global public health Globulin hACE2 healthy donor healthy donors high-affinity binding human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hyperimmune hyperimmune globulin IFNAR Immunotherapy in vitro Injury lung N-terminal domain neutralization neutralization potency neutralization titer nucleocapsid nucleocapsid protein omicron Omicron variants P.1 Passive immunotherapy plasma potent Prophylactic Protein pseudotyped RBD RBD binding Receptor-binding domain reduced reduction in S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus significantly Sinopharm sinopharm COVID-19 vaccine. subsequent the receptor-binding domain the S protein Treatment variants variety viral loads weight loss
[DOI] 10.1002/advs.202104333 PMC 바로가기 [Article Type] Article

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19

펩티드 기반 치료제: COVID-19에 대한 새로운 잠재적 치료제

Review

Published on 2022-05-012022-09-11
Journal: Thérapie [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 임상, 치료제,

[키워드] antimicrobial peptide antiviral activity Antiviral agents blocked causative agent cell membrane cleave clinical trials COVID-19 COVID-19 outbreak drug drugs feasibility form fusion hACE2 host cell host cell membrane Human humans In silico method inhibitor Interaction intestine intestines lactoferrin lung Lungs mechanism MERS outbreak pandemic peptide peptide-based peptides Peptides-based therapeutics positive-sense RNA virus potential therapeutic agent RNA virus S protein S protein-hACE2 interaction S1 subunit S2 subunit SARS-CoV-2 shown the S1 subunit the SARS-CoV-2 therapeutic viral envelope viral infection
[DOI] 10.1016/j.therap.2021.09.007 PMC 바로가기 [Article Type] Review

A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model

SARS-CoV-2 감염 모델에서 질병으로부터 보호하는 한 쌍의 비경쟁 중화 인간 단일클론 항체

Article

Published on 2022-05-012022-09-11
Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] Analysis animals antibodies antibody binding candidate cellular receptor cellular receptor hACE2 Cluster competing COVID-19 disease DNA DNA sequence hACE2 human ACE2 human immunoglobulin human monoclonal antibodies Human monoclonal antibody IC50 Immunoglobulin mice N-terminal domain neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody pandemic platform powerful tool Prophylaxis Receptor-binding domain reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein selected Spike protein Support the receptor-binding domain the SARS-CoV-2 the spike protein therapy transgenic variants variants of concern Viral viral spread weight loss
[DOI] 10.1002/eji.202149374 PMC 바로가기 [Article Type] Article

Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

백신 접종으로 유도된 오미크론 포함 SARS-CoV-2 변이체에 대한 광범위 중화 항체

Article

Published on 2022-04-272022-09-11
Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] ACE2 Adenovirus Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies Antibody Response Beta binding broad spectrum Complete complex COVID-19 vaccine Cryo-electron microscopy defined Delta demonstrated develop drug elicited epitope exhibited Gamma hACE2 highlighting Infection investigated K18-hACE2 mAb monoclonal antibody nCoV neutralization neutralizing antibody omicron other variant other variants Prophylactic Protein Protein binding provided Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the RBD the spike protein therapeutic Transgenic mouse vaccination Vaccines variant VOCs
[DOI] 10.1038/s41392-022-00987-z PMC 바로가기 [Article Type] Article

Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron

치명적인 SARS-CoV-2 감염 표적 수용체 결합 에피토프로부터 보호하는 나노바디는 오미크론 이외의 바이러스 변이체에 보존되어 있습니다

Article

Published on 2022-04-252022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종,

[키워드] affinity antibody binding binding epitope binding mode blocked cell cultures cell entry cell entry receptor competition coronavirus COVID-19 COVID-19 pandemic cryo Cryo-electron microscopy electron microscopy Epitopes fusion glycoprotein groups hACE2 heavy chain human ACE2 humanized immune Immune escape immunized lethal mice Microscopy mono MOST nanobodies nanobody neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibody nine omicron Other Prevent prevented progression Protecting pseudotyped RBD RBD binding RBM receptor receptor binding motif Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants selected target the receptor-binding domain the S protein therapeutic potential Therapeutics Vaccine variant variants of concern virus
[DOI] 10.3389/fimmu.2022.863831 PMC 바로가기 [Article Type] Article

An in-silico study of the mutation-associated effects on the spike protein of SARS-CoV-2, Omicron variant

SARS-CoV-2, Omicron 변이체의 스파이크 단백질에 대한 돌연변이 관련 효과에 대한 in-silico 연구

Article

Published on 2022-04-212022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종,

[키워드] accompanied Affect alkalinity all-atom molecular dynamics simulations B.1.1.529 change Combination concern COVID-19 pandemic Critical decrease delta variant demonstrated Effect electrostatic epitope Epitopes exhibit functional hACE2 Health higher affinity hydrogen Hydrogen bond hydrogen bonds hydrophobic hydrophobic interaction hydrophobic interactions hydrophobicity in silico Approach in-silico increase in Infection Interaction modulate molecular dynamics Molecular dynamics simulation mutated Mutation new infection omicron Omicron variant predict predicted Protein RBD receptor Receptor-binding domain residue residues SARS-CoV-2 spike glycoprotein Spike protein the RBD the receptor-binding domain the spike protein transmission rate variant Variation variations virus
[DOI] 10.1371/journal.pone.0266844 PMC 바로가기 [Article Type] Article

Interaction Analysis of the Spike Protein of Delta and Omicron Variants of SARS-CoV-2 with hACE2 and Eight Monoclonal Antibodies Using the Fragment Molecular Orbital Method

단편 분자 궤도 방법을 사용한 hACE2 및 8개의 단일클론 항체와 SARS-CoV-2의 델타 및 오미크론 변이체의 스파이크 단백질 상호작용 분석

Article

Published on 2022-04-112022-09-11
Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin binding binding affinities binding affinity changed changes in coronavirus crystal structure Delta eight enzyme fragment hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Interaction molecular monoclonal antibodies monoclonal antibody mutated Mutation omicron Omicron variant performed predict predicted Protein Quantum mechanics required residue respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein statistical analysis the binding affinity the Spike the spike protein variant variant of SARS-CoV-2 Viral viral surface
[DOI] 10.1021/acs.jcim.2c00100 PMC 바로가기 [Article Type] Article