Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORM-a prospective, randomized, single-centre, open-label study염증 표지자가 상승한 입원한 COVID-19 환자에서 토실리주맙의 조기 투여; COVIDSTORM-전향적, 무작위, 단일 센터, 공개 라벨 연구Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, [키워드] (interleukin-6 activities addition administration Admission benefit C-reactive protein clinical clinical recovery clinical status control group control patient control patients COVID-19 D-dimer demonstrated discharged elevated ferritin hospital Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient Hypoxemia immune response Inflammation inflammation markers Inflammatory inflammatory biomarkers intensive care intensive care unit admission interleukin interleukin-6 interquartile range marker median Open-label Ordinal Scale Patient patients hospitalized primary endpoint Randomized respiratory Respiratory Support SARS-CoV-2 secondary endpoint Secondary endpoints seven-category ordinal scale severe COVID-19 significantly SOC Standard of care TCZ Tocilizumab with COVID-19 [DOI] 10.1016/j.cmi.2022.02.027 PMC 바로가기 [Article Type] Randomized Controlled Trial
Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients입원한 COVID-19 환자의 혈장에서 프롤린 특이적 펩티다제 활성(DPP4, PRCP, FAP 및 PREP)Article Published on 2022-06-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] MERS, 바이오마커, 진단, [키워드] Activation activities activity Alpha Biomarker changes in collected coronavirus COVID-19 COVID-19 patient COVID-19 patients decrease dipeptidyl peptidase Dipeptidyl peptidase 4 discharge DPP4 dysregulated dysregulation elevated FAP feature fibroblast Fibroblast activation protein alpha Follow-up healthy control healthy controls Hospital admission Hospital stay Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients immune system investigated pathophysiological patients peptidase plasma PRCP PrEP proline Prolyl oligopeptidase Prolylcarboxypeptidase. Protein remained Sepsis Septic shock significantly significantly increased significantly lower utility were measured while [DOI] 10.1016/j.cca.2022.03.005 PMC 바로가기 [Article Type] Article
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patientsSARS-CoV-2의 지속적인 바이러스 RNA 방출은 입원한 COVID-19 환자의 섬망 발병률 및 6개월 사망률과 관련이 있습니다Article Published on 2022-06-012022-09-12 Journal: GeroScience [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI age BMI Chronic kidney disease Corticosteroid COVID-19 COVID-19 hospitalization delirium Diabetes Mellitus diagnosis of COVID-19 dysfunction Factor hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient implication In-hospital incidence increasingly initial Logistic regression Male sex Medicine Mortality occur Occurrence outcome Patient persistent positive predictor remained SARS-CoV-2 SARS-CoV-2 RT-PCR severity shedding significantly Viral RNA shedding viral shedding [DOI] 10.1007/s11357-022-00561-z PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients입원한 COVID-19 환자의 호기에서 SARS-CoV-2 RNAArticle Published on 2022-05-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition breath contagiousness contribute COVID-19 demonstrated distress droplets epidemiological studies feasible hospitalized COVID-19 patient hospitalized COVID-19 patients Infection management nasopharyngeal pandemic Patient patients required respiratory distress Saliva SARS-CoV-2 RNA SARS-CoV-2 transmission Spread throat swab Transmission Viral Viral detection virus [DOI] 10.1038/s41598-022-13008-4 PMC 바로가기 [Article Type] Article
The role of kidney dysfunction in COVID-19 and the influence of age Research Published on 2022-05-232022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 95% confidence interval Accuracy age AKI Analysis approach baseline Cohort Comorbidities COVID-19 COVID-19 patient COVID-19 severity D-dimer death demonstrated elderly patients examined GFR glomerular filtration rate Hospital admission hospitalized COVID-19 patient hypertension impairment Italy kidney dysfunction Kidney function Kidney injury logistic regressions Mortality occurred Occurrence outcome performed predict Predictive procalcitonin progression reached Retrospective study risk factor severity [DOI] 10.1038/s41598-022-12652-0 [Article Type] Research
Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes-A Single-Center Experience and a Brief Review of the LiteratureCOVID-19 환자의 낮은 혈청 비타민 D는 염증 마커 및 환자의 결과와 관련이 없습니다-단일 센터 경험 및 문헌에 대한 간략한 검토Review Published on 2022-05-102022-09-11 Journal: Nutrients [Category] MERS, 바이오마커, [키워드] Admission age association C reactive protein Comorbidities Comorbidity correlation COVID-19 CRP disease disease severity evaluate except for experience ferritin fibrinogen form forms groups highest hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patients Inflammation Inflammatory Inflammatory biomarker inflammatory biomarkers IQR Laboratory laboratory procedures leukocytes literature median Mild Mild disease moderate Patient Peripheral blood peripheral blood leukocytes Prospective Study review Serum level serum levels severe COVID-19 significantly significantly higher significantly lower stratified subject Vitamin D vitamin D level vitamin D levels vitamin D serum Vitamin D status was collected was performed were assessed [DOI] 10.3390/nu14101998 PMC 바로가기 [Article Type] Review
Gastrointestinal manifestations of COVID-19 in a single center in the Eastern Province of Saudi ArabiaObservational Study Published on 2022-05-012022-10-04 Journal: Saudi journal of gastroenterology : official journ [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI abdominal pain acute respiratory distress Altered mental status AOR association conducted COVID-19 COVID-19 infection Cytokine storm syndrome death diarrhea Gastrointestinal gastrointestinal manifestations GI symptom higher risk hospital hospitalized COVID-19 patient less lower mortality lung field lung infiltration manifestation Manifestations Middle East Mortality mortality rate multiorgan failure nausea Novel coronavirus outcome Patient patients PCR test positive Prevalence reported retrospective Saudi Arabia severe COVID-19 disease severity single center Symptom syndrome university hospital vomiting [DOI] 10.4103/sjg.sjg_547_21 PMC 바로가기 [Article Type] Observational Study
Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia입원한 COVID-19 환자와 정상 인지, 경도 인지 장애 또는 알츠하이머 치매가 있는 비 COVID-19 환자의 혈청 신경퇴행성 바이오마커 비교Article Published on 2022-05-012022-09-11 Journal: Alzheimer's & dementia : the journal of the Alzhei [Category] MERS, 바이오마커, [키워드] Acidic Alzheimer's disease amyloid beta Biomarker Biomarkers Cognitive impairment Complication Control correlated COVID COVID patient Covid patients COVID-19 COVID-19 patient Dementia died discharge home discharged home disease elevated Encephalopathy GFAp Glial fibrillary acidic protein hospitalized COVID-19 patient hospitalized COVID-19 patients In-hospital In-hospital death light chain marker Mild Mortality neurodegeneration neurodegenerative neurofilament light chain Neurological complications outcome Patient phosphorylated Protein SARS-CoV-2 serum severity significantly significantly lower subject survival tau. UCHL1 [DOI] 10.1002/alz.12556 PMC 바로가기 [Article Type] Article
Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19Research article Published on 2022-05-012022-10-05 Journal: Clinical neurophysiology : official journal of the [Category] 바이오마커, 유전자 메커니즘, [키워드] abnormality Cohort collected Comorbidities COVID-19 COVID-19 pandemic COVID-19 patient Critical died discharge EEG electroencephalogram Electroencephalography epileptiform Factor Hemorrhagic Stroke hospital hospitalized COVID-19 patient hospitalized COVID-19 patients increasing age indication Injury MOST NeuroCOVID New York City nonspecific objective occurred outcome Patient patients patients with COVID-19 performed Result retrospective Risk factors Seizure Seizures severe COVID-19 Significance stroke Treatment [DOI] 10.1016/j.clinph.2022.03.001 [Article Type] Research article
Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patientsObservational Study Published on 2022-05-012022-10-05 Journal: The American journal of clinical nutrition [Category] 임상, [키워드] 25-hydroxyvitamin D 28-day mortality 95% CI age albumin Analysis analyzed approved bioavailable vitamin D calculated case notes circulating clinical Comorbidities Concentration conducted coronavirus disease COVID-19 COVID-19 mortality DBP deficiency defined died ethics committee Free free vitamin D Frequency hospitalized COVID-19 patient hospitalized patient increased mortality Logistic regression male Mortality mortality risk mortality risks nonsurvivor Older outcomes patients with COVID-19 Protein relationship sera serum severe deficiency Sex Study protocol survivor Vitamin D Vitamin D status vitamin D-binding protein vitamin D–binding protein. were measured [DOI] 10.1093/ajcn/nqac027 PMC 바로가기 [Article Type] Observational Study