RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in BetacoronavirusArticle Published on 2022-01-012022-11-16 Journal: RNA Biology [Category] 변종, [키워드] analysed Analysis Antiviral bat bat virus bats Betacoronavirus build changes in coding complement conserved cross-species horizontal transmission D614G develop disrupt events Factor function Genome genome-wide analysis Health hosts hotspot Human Impact in viral information investigated jumping the species barrier MERS-CoV Missense mutation molecular molecular evolution Mutation natural selection overlap Positive selection Protein Proteins Research reservoir RNA RNA genome RNA structure RNA structures RNA viruses S protein SARS-CoV SARS-CoV-2 secondary RNA structures selected small RNA spike Surveillance the Betacoronavirus the S protein Therapeutic strategies Transmission viral genome Viral proteins viral RNA genome viral RNA genome. Viral transmission [DOI] 10.1080/15476286.2022.2115750 PMC 바로가기
Critical Role of the Subways in the Initial Spread of SARS-CoV-2 in New York CityPublic Health Published on 2021-12-232022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Analysis community transmission COVID-19 COVID-19 incidence cumulative dissemination Evidence FIVE hospitalizations hotspot incidence of COVID-19 Infection initial Local multi-generational household transmission network models New York City percolation Phylogenetic analysis Predictive public transport role SARS-CoV-2 smartphone device tracking spatial regression analysis Spread subsequent subway viral isolates Volume [DOI] 10.3389/fpubh.2021.754767 PMC 바로가기 [Article Type] Public Health
Household serial interval of COVID-19 and the effect of Variant B.1.1.7: analyses from prospective community cohort study (Virus Watch)Research Article Published on 2021-12-212022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] affected analysed Analysis average B.1.1.7 B.1.1.7 variant caused cohort study Community COVID-19 COVID-19 pandemic England English Epidemiology estimate Evidence explain hotspot household illness Increased individual Infection National no significant difference positive positive swab previous study Receptor binding Region reported SARS-CoV-2 Serial interval Spread surveillance data tested the mean Transmissibility UK undergo variant of concern Viral load viral shedding VoC [DOI] 10.12688/wellcomeopenres.16974.2 PMC 바로가기 [Article Type] Research Article
Knowledge into the Practice against COVID-19: A Cross-Sectional Study from GhanaCOVID-19에 대한 실천에 대한 지식: 가나의 횡단면 연구Article Published on 2021-12-072022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, [키워드] acceptance adjusted affected African Attitudes authority Characteristics cholera comparable Compliance conducted country COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 vaccine Critical cross-sectional cross-sectional study effective intervention effective interventions Europe Face masks Ghana Government hand washing hotspot include Influenza knowledge knowledge of COVID-19 linear linear multiple regression analysis Local lockdown measure Multiple regression analysis open pandemic Population Practice practices against COVID-19 preventive measure preventive measures problem public health public health communication Public health intervention questionnaire Region reported soap social distancing socio-demographic socio-demographics Spread the disease turn vaccination variant Viral Viral variants virus wearing [DOI] 10.3390/ijerph182412902 PMC 바로가기 [Article Type] Article
Hotspot Mutations in SARS-CoV-2Genetics Published on 2021-11-292022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome addition amino acid change Analysis calculated carried Characteristics coding region Coronavirus-2 country COVID-19 Deletion deletions Entropy Evolution example functional consequence global pandemic greater hotspot hotspot mutations human Ace2 protein L452R MAFFT Missense mutations Multiple sequence alignment Mutation mutations N501Y Non-synonymous Patient performed Phylogenetic analysis Protein resulting SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 sequence sequence spike Spread Structure Substitution T478K the binding affinity the receptor-binding domain unique vaccination variants of concern virus virus strain Wuhan, China [DOI] 10.3389/fgene.2021.753440 PMC 바로가기 [Article Type] Genetics
Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer SimulationsImmunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Affect affinity antibody approach assessment bind binding affinities binding affinity Biomolecule can be used cause change circulating computer Coronavirus disease 2019 COVID-19 domain Dynamics Effect experimental work expression facilitate hACE2 hACE2 receptor helping host cell membrane hotspot Human human ACE2 human Angiotensin-converting enzyme infect Infection modulate molecular dynamics mutated Mutation mutations Neutralizing Neutralizing antibodies protein-protein interaction protocol Rapid S-RBD S1 domain S2 domain SARS-CoV-2 SARS-CoV-2 genome Screening selected Simulation spike spike glycoprotein Spike protein Spike-RBD the binding affinity time-consuming vaccination variant virus [DOI] 10.3389/fimmu.2021.730099 PMC 바로가기 [Article Type] Immunology
Estimating Economic Losses Caused by COVID-19 under Multiple Control Measure Scenarios with a Coupled Infectious Disease—Economic Model: A Case Study in Wuhan, ChinaArticle Published on 2021-11-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] average caused Contact Control control measures COVID-19 COVID-19 epidemic COVID-19 infected patient COVID-19 pandemic Economic losses effective hotspot impacted Infectious disease infectious diseases model less measure Multiple outbreak parameter public health crisis quantitative assessment quarantined patient reduce Research scenario SEIR Spread spread of COVID-19 threshold value Wuhan Wuhan, China [DOI] 10.3390/ijerph182211753 PMC 바로가기 [Article Type] Article
Cold traps as reliable devices for quantitative determination of SARS-CoV-2 load in aerosols에어로졸 내 SARS-CoV-2 부하의 정량적 측정을 위한 신뢰할 수 있는 장치로서의 콜드 트랩Article Published on 2021-11-082022-09-11 Journal: Environmental Monitoring and Assessment [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aerosol Aerosols Algorithm area of interest can be used carrier carriers Cold collected Concentration Contamination coronavirus COVID-19 detect determined by Early detection effective eliminated handling hazards help hotspot identify Indoor hotspots Isolation MALL nasal New new SARS-CoV-2 not effective Occurrence outbreak PCR pharyngeal mucosa positioned Public places Quantitative quantitative determination quantitative real time PCR reached real time real time PCR respiratory SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 testing SARS-CoV-2 variants School Schools Spread Spreading kinetics supplementary material Surveillance swabs today Transmissibility Transmission variant Ventilation Viral viral mutation viral presence virus were recorded zone [DOI] 10.1007/s10661-021-09580-3 PMC 바로가기 [Article Type] Article
In silico binding profile characterization of SARS-CoV-2 spike protein and its mutants bound to human ACE2 receptorSARS-CoV-2 스파이크 단백질 및 인간 ACE2 수용체에 결합된 돌연변이체의 인 실리코(in silico) 결합 프로필 특성화Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected approach binding binding affinities binding affinity binding free energies binding free energy complexes coronavirus country COVID-19 decomposition domain drug resistance free energies free energy Free energy calculation and decomposition Free energy calculations G476S hACE2 hACE2 protein hotspot Hotspot residues human ACE2 human ACE2 receptor infect interfere investigated MD simulation molecular molecular dynamics Molecular mechanics mutant nine Novel coronavirus pandemic Poisson Protein–protein interaction protocol prototype provide RBD RBD mutations RBDs receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs spike spike glycoprotein Spike RBD/hACE2. Structure structures surface area V367F V483A Vaccine virus [DOI] 10.1093/bib/bbab188 PMC 바로가기 [Article Type] Article
virusMED: an atlas of hotspots of viral proteinsResearch Papers Published on 2021-11-012022-10-29 Journal: IUCrJ [Category] COVID-19, [키워드] antigen epitope antiviral drugs atomic binding binding site characterized Critical database drug DrugBank Epitopes FDA-approved drugs functional Google Map HIV-1 hosts hotspot in viral Influenza Interaction metal metal ions Protein Research SARS-CoV-2 viruses specific antibody Strains structures therapeutic agent valuable resource viral infections viral metal proteins Viral protein viral protein structures Viral proteins virus virus hotspots virus strain virusMED database [DOI] 10.1107/S2052252521009076 PMC 바로가기 [Article Type] Research Papers