A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants결합이 강화되었지만 효소 활성이 제거된 인간 ACE2는 SARS-CoV-2 변이체를 효율적으로 중화합니다Comment Published on 2022-01-112022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, [키워드] human ACE2 Molecular biology neutralize SARS-CoV-2 variant structural biology [DOI] 10.1038/s41392-021-00821-y PMC 바로가기 [Article Type] Comment
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift Research Published on 2022-01-112022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acid substitution antigenic antigenic site bind conserved convalescent individual dose Effectiveness ENCODE epitope fraction human ACE2 immune evasion in vitro individual less magnitude monoclonal antibody MOST neutralized Neutralizing Neutralizing activity neutralizing antibody neutralizing monoclonal antibody omicron overcome pandemic plasma pseudovirus raising RBD receptor-binding motif recognize reductions in sarbecovirus SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain the spike protein Vaccine variant Wuhan-Hu-1 zoonotic [DOI] 10.1038/s41586-021-04386-2 [Article Type] Research
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo이중특이성 단량체 나노바디는 스파이크 삼량체 이량체를 유도하고 생체 내에서 SARS-CoV-2를 중화합니다Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies binding Antiviral Beta Beta variant binding coronavirus cross-neutralize Delta variants elicited host cell host cell receptor human ACE2 in vivo inactivation induce inhibit interact Isolation mechanisms mice monomeric nanobody neutralization neutralize RBD RBDs respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike trimer therapeutic Therapeutic molecule therapeutic molecules therapeutic potential Transgenic mouse Trimers variant variants variants of concern Viral Viral antigen viral antigens viral infection virus [DOI] 10.1038/s41467-021-27610-z PMC 바로가기 [Article Type] Article
Growth, Antigenicity, and Immunogenicity of SARS-CoV-2 Spike Variants Revealed by a Live rVSV-SARS-CoV-2 VirusMedicine Published on 2022-01-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] anti-viral drug antibodies antibody antigenicity Beta comparable convalescent COVID-19 patients coronavirus Efficacy elicit G protein Growth Curve hamsters Health human ACE2 immunogenicity in vitro Infectivity introduced mice mutant mutant virus Mutation neutralized Neutralizing antibody response neutralizing monoclonal antibody pandemic RBD recurrent mutation resulting Revealed RNA virus SARS-CoV-2 selected sera single dose spike spike variant the receptor-binding domain therapeutic Vaccine Vaccines variant variants VSV wild-type wild-type virus [DOI] 10.3389/fmed.2021.793437 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2SARS-CoV-2 Omicron RBD는 인간 ACE2에 대해 현재 지배적인 Delta 변이체보다 약한 결합 친화력을 나타냅니다.Comment Published on 2022-01-052022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, [키워드] binding affinity Biochemistry Computational biology and bioinformatics delta variant dominant human ACE2 omicron RBD SARS-CoV-2 [DOI] 10.1038/s41392-021-00863-2 PMC 바로가기 [Article Type] Comment
Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein자기 마이크로비드 친화성 선택 스크리닝의 발전: SARS-CoV-2 스파이크 단백질에 대한 천연 리간드의 발견Article Published on 2022-01-052022-09-11 Journal: Journal of the American Society for Mass Spectrome [Category] Coronavirus, SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance affinity Amino acid amino acid sequence angiotensin Angiotensin converting enzyme-2 antibodies applied approaches binding caused complex coronavirus COVID-19 enzyme glycyrrhiza High-resolution HPLC human ACE2 human cell human cells include Interaction licochalcone a Ligand ligands Like mass spectrometry Microbead natural peptide pharmacological Prevent Protein subunit receptor robotics S1 protein SARS-CoV-2 SARS-COV-2 infection Selection sensitivity sequence severe acute respiratory syndrome Coronavirus small molecule Small molecules spike Spike protein subunit Tandem mass spectrometry targets the S1 protein the SARS-CoV-2 therapeutic agent therapeutic agents throughput treat virus spike protein [DOI] 10.1021/jasms.1c00318 PMC 바로가기 [Article Type] Article
Osteoclast-mediated bone loss observed in a COVID-19 mouse modelCOVID-19 마우스 모델에서 관찰된 파골세포 매개 뼈 손실Article Published on 2022-01-012022-09-11 Journal: Bone [Category] SARS, 치료기술, [키워드] added affected aging analyzed animal Asymptomatic body weight bone Bone mass consequence controls cortical cortical bone COVID-19 criteria days post infection death Decline decrease develop eight euthanized examined expressing fraction greater group groups hACE2 Health healthy help human ACE2 human disease human SARS-CoV-2 increase in increases in Infection intranasal K18-ACE2 K18-hACE2 K18-hACE2 transgenic mice knowledge mice moderate moderate disease moderate to severe Musculoskeletal Musculoskeletal health musculoskeletal system no difference no differences non-infected Osteoclasts parameter Patient plaque forming units Post-infection posture receiving reduction in remained resulting risk robust SARS-CoV-2 SARS-COV-2 infection severe disease skeletal staining TRAP treated Viral load viral loads Volume volume fraction were infected while [DOI] 10.1016/j.bone.2021.116227 PMC 바로가기 [Article Type] Article
DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemicSARS-CoV-2 대유행을 치료하는 혁신적인 방법으로 안지오텐신 전환 효소 2를 마스킹하는 DNA 앱타머Article Published on 2022-01-012022-09-11 Journal: Pharmacological research [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 applied approach binding biochemical assay Cell cellular cellular receptor clinical development Corona coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 therapy demonstrated disease DNA DNA molecule docking effective enzyme Evolution experiment form glycoprotein human ACE2 identify Immune-mediated in silico Infection inhibitors Interaction K353 Ligand ligands mechanism mutant neutralization nucleic acid Nucleic acid-based drugs pandemic Prevent residue SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 variants steric hindrance target cell the SARS-CoV-2 therapeutic treat variant viral infection viral variant Virus Disease [DOI] 10.1016/j.phrs.2021.105982 PMC 바로가기 [Article Type] Article
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in miceNLRP3 인플라마좀의 특정 억제는 면역 과잉 활성화를 억제하고 생쥐의 병리와 같은 COVID-19를 완화합니다Article Published on 2021-12-312022-09-11 Journal: EBioMedicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] activated Activation advance alleviate biosafety level BSL-3 Bureau C57BL/6 CAS Cell culture cell cultures conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 severity Cytokines education Evidence finding funding global public health histological host gene Host immune response human ACE2 immune immunofluorescence analysis immunopathology indicated inhibition inhibitor injected Intervention intranasally intraperitoneally Invasion involved knockout mice Laboratory level 3 live SARS-CoV-2 Lung inflammation lung tissue lung tissues Lungs macrophages MCC950 mice NLRP3 NLRP3 inflammasome pandemic pathology performed pro-inflammatory cytokine pro-inflammatory cytokines Program provided quantitative real-time PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, NLRP3 inflammasome, Immune overactivation, Cytokine storm Science severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe pathology severity Specific supported suppresse targeting THP-1 tissues transgenic mice Vaccine development Viral was reduced West wild-type with COVID-19 [DOI] 10.1016/j.ebiom.2021.103803 PMC 바로가기 [Article Type] Article
Omicron SARS-CoV-2 Variant Spike Protein Shows an Increased Affinity to the Human ACE2 Receptor: An In Silico AnalysisArticle Published on 2021-12-312022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 ACE2 receptor addition affinity angiotensin-converting enzyme 2 binding affinity binding free energy change changes in charged residues Community contribute docking electrostatic interaction evaluated GISAID HADDOCK host receptor Human human ACE2 human host Increased Interaction modulate Mutation occurred omicron pathogenicity retrieved SARS-CoV-2 SARS-CoV-2 variants show spike Spike protein the SARS-CoV-2 variant variants viral spike virus WT spike [DOI] 10.3390/pathogens11010045 PMC 바로가기 [Article Type] Article