Old drug, new Trick? The rationale for the treatment of COVID-19 with activated protein C오래된 약, 새로운 트릭? 활성화된 단백질 C로 코로나19를 치료하는 근거Article Published on 2021-04-012022-09-11 Journal: Medical Hypotheses [Category] 치료법, 치료제, [키워드] activated activated protein C adaptive Antiviral agents antiviral treatments apixaban approach Aspirin clinical trial Coagulation consequence convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 therapeutics COVID-19 therapeutics. current described dysregulated immune response evaluated followed by heparin heparins Hope Hypothesis identify immune immune response immunomodulator immunomodulators Infection Inflammatory mechanism monoclonal antibodies Protein protein C researcher steroid Steroids therapeutic interventions therapeutic target Therapies therapy treating COVID-19 patient Treatment [DOI] 10.1016/j.mehy.2021.110537 PMC 바로가기 [Article Type] Article
Zoonotic coronavirus epidemics: Severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019동물원성 코로나바이러스 전염병: 중증 급성 호흡기 증후군, 중동 호흡기 증후군 및 코로나바이러스 질병 2019Review Published on 2021-04-012022-09-11 Journal: Annals of allergy, asthma & immunology : official [Category] SARS, 치료제, [키워드] acute respiratory syndrome Affect allergy Antiviral Asthma atopy Basic science biologic Biologic therapy caused Clinical characteristics clinical courses clinical manifestation clinical manifestations Clinical outcome coronavirus coronavirus disease Coronavirus disease 2019 coronavirus epidemics Corticosteroids courses COVID-19 COVID-19 infection database deaths deficiencies deficiency disease disease control Effect effective Efficacy Epidemiology fatal disease immunodeficiency immunology immunomodulator immunomodulators Inconclusive Infection inhaled corticosteroid inhaled corticosteroids international public health landscape less maintain MERS Middle East Middle East respiratory syndrome Mild National nucleic acid nucleic acid amplification nucleic acid amplification tests organ organ system outcomes Patient primary antibody Primary Immunodeficiency Severe acute respiratory syndrome syndrome T-cell Therapies therapy Treatment treatment for COVID-19 Virology worldwide pandemic Zoonotic coronavirus [DOI] 10.1016/j.anai.2020.11.021 PMC 바로가기 [Article Type] Review
Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review항종양 및 항바이러스 잠재력을 갖지만 약물 유발 간 손상을 갖는 레플루노마이드 면역조절제: 포괄적인 검토Review Published on 2021-04-012022-09-11 Journal: International immunopharmacology [Category] SARS, 임상, 치료제, [키워드] affected Anti-inflammatory Antineoplastic Antiviral antiviral activity approved Arthritis Autoimmune benefit Bilirubin Biomarkers catalytic Cell cell growth cellular Combination Compound COVID-19 Cytokines de novo synthesis DHODH drug drug-induced Drug-induced liver injury enzyme event growth hepatic impairment hepatic injury Immunoglobulin immunological immunomodulator Immunosuppression inhibit inhibitors joint destruction leflunomide Leflunomide. liver liver enzyme liver enzymes Liver injury membrane mitochondrial nucleotide nucleotides off-label outcome Pathogenesis pathophysiology Patient Perspective pharmacological precautions proliferation Protective Protein pyrimidine reducing Regulatory Relapsing-Remitting Multiple Sclerosis reported required responsible Rheumatoid safety profile SARS CoV SARS CoV-2 serum Treatment Trial tyrosine with COVID-19 [DOI] 10.1016/j.intimp.2021.107398 PMC 바로가기 [Article Type] Review
Immune dysregulation and system pathology in COVID-19COVID-19의 면역 조절 장애 및 시스템 병리Review Published on 2021-03-232022-09-10 Journal: Virulence [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antiviral drug antiviral drugs approved ARDS ards and multiple organs failure cause caused characterized Clinical characteristics Clinical features clinical trial Combination Comorbidities confirmed case coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine Cytokine release syndrome Cytokine storm dysregulated immune response dysregulation epidemiological Epidemiology exaggerated immune response Fatality rate focus global public health health authorities Health crisis immunomodulator immunomodulators increase Infection Local lymphopenia Mortality multiple organ Novel coronavirus Pathogenesis pathology patients patients with SARS-CoV-2 reported Research respiratory distress SARS-CoV-2 SARS-COV-2 infection Septic shock suggested syndrome the cytokine storm Therapeutic strategies Treatment [DOI] 10.1080/21505594.2021.1898790 PMC 바로가기 [Article Type] Review
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical ResearchPharmacology Published on 2021-03-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity acute respiratory distress Against Antiviral Antiviral agents ARDS AYUSH medicine caused chemokine China Clinical research clinical study clinical testing clinical trial COVID-19 drug effector cells Fatality rate Formulation global scientific community Health immune immunomodulator immunomodulators immunomodulatory India indian medicinal plants Indian people indian traditional medicine information investigated less Medicine National Occurrence Patient plant plants platform Potential pro-inflammatory cytokine public health reaction reported Research S proteins SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection severe disease suggested syndrome systemic inflammatory tested Wuhan [DOI] 10.3389/fphar.2020.578970 PMC 바로가기 [Article Type] Pharmacology
Impact of COVID-19 outbreak on the care of patients with inflammatory bowel disease: A comparison before and after the outbreak in South ChinaObservational Study Published on 2021-03-012022-10-05 Journal: Journal of gastroenterology and hepatology [Category] 임상, [키워드] bowel Care China comparable COVID-19 COVID-19 outbreak decrease Elective surgery Health Health care health-care IBD immunomodulator Impact Inflammatory Inflammatory bowel disease investigated median medication outbreak Patient patients performed physician questionnaire significantly higher South supported the mean [DOI] 10.1111/jgh.15205 PMC 바로가기 [Article Type] Observational Study
Tocilizumab administration is associated with the reduction in biomarkers of coronavirus disease 2019 infection토실리주맙 투여는 코로나바이러스 질병 2019 감염의 바이오마커 감소와 관련이 있습니다Meta-Analysis Published on 2021-03-012022-08-31 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 95% CI administration Analysis article benefit Biomarker Biomarkers C-reactive protein caused confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection D-dimer database death case dimer effective Effectiveness Evidence ferritin immunomodulator increment Infection interleukin interleukin-6 life lymphocyte Lymphocyte count mean difference Meta-analysis number of death Patient Potential treatment procalcitonin PubMed Central random reducing reduction reduction in retrieved searched severity the disease Tocilizumab Treatment [DOI] 10.1002/jmv.26698 PMC 바로가기 [Article Type] Meta-Analysis
An overview of some potential immunotherapeutic options against COVID-19Review Published on 2021-02-262022-10-04 Journal: International immunopharmacology [Category] MERS, 신약개발, [키워드] Abstract ACE2-Fc acute respiratory syndrome administration anti-inflammatory drug antibodies approach approved candidate cascade cell-based therapies complement convalescent plasma coronavirus COVID-19 COVID-19 vaccine cytokine Effectiveness effort immune component immune responses immunomodulator Immunotherapy Improvements Inflammatory Inflammatory cytokines interferon involved kinase knowledge lack mechanism of action pandemic Passive Pathogenesis provided resulting SARS-CoV2 SARS-CoV2 infection severe cases syndrome targets the disease therapy for COVID-19 Vaccine Vaccines viral infection Virus neutralization with COVID-19 [DOI] 10.1016/j.intimp.2021.107516 PMC 바로가기 [Article Type] Review
Pregnancy and COVID-19: pharmacologic considerations임신과 코로나19: 약리학적 고려사항Review Published on 2021-02-012022-09-11 Journal: Ultrasound in obstetrics & gynecology : the offici [Category] 임상, [키워드] (Tocilizumab) Administered aerosolization Algorithm Analgesia anticoagulation Aspirin benefit caution clinical trials Comorbidity Complication contraindication contraindications convalescent plasma coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids Course COVID-19 Critical Critical illness Dexamethasone disease onset disease severity during pregnancy Evidence fetal general anesthesia gestation Gynecology hand hypoxia immunomodulator immunomodulators indicated Inhaled interferon Intervention lactating lactation Lopinavir Lopinavir/ritonavir low-dose lung Magnesium magnesium sulfate maturation mechanically ventilated monoclonal antibodies monoclonal antibody neuromuscular blockade nitric oxide Nitrous oxide non-pregnant population non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs obstetrics opioids oxygen Patient patient-controlled analgesia Personal protective equipment Pregnancy pregnancy complications pregnant pregnant patient pregnant patients Prevent Prophylaxis reduce Remdesivir remifentanil renal respiratory respiratory depression risk Ritonavir Seizure shown Society Son sulfate supplemental oxygen tacrolimus Thromboprophylaxis Tocilizumab Treatment Ultrasound with COVID-19 [DOI] 10.1002/uog.23116 PMC 바로가기 [Article Type] Review
Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro시험관 내 SARS-CoV-2 바이러스 복제를 억제하는 강력한 활성을 가진 항말라리아 약물인 QuinacrineArticle Published on 2021-01-172022-09-10 Journal: Viruses [Category] 치료제, [키워드] acidic organelles activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anticancer antimalarial antiviral activities antiviral activity antiviral drugs Antiviral effect clinical study Concentration confocal microscopy copy numbers coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutaneous lupus erythematosus cytotoxicity determinate determined by Diseases drug effective electron enzymatic activity evaluate immunomodulator Infection inhibiting modulating MOIs molecule MTT Phospholipase A2 quinacrine raise real-time RT-PCR reduce Replication respiratory rheumatological RNA SARS CoV-2 SARS-CoV-2 SARS-CoV-2 virus shown Strong treated Vero E6 Vero E6 cell VERO E6 cells Viral viral cell viral copy numbers viral cytotoxicity viral DNA virus virus replication was determined were infected [DOI] 10.3390/v13010121 PMC 바로가기 [Article Type] Article