macaque – Page 7 – Communicable Diseases Research

Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus

Research Article

Published on 2021-05-242022-10-30
Journal: JCI Insight [Category] COVID-19,

A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques

Article

Published on 2021-05-182022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] accumulates acute respiratory syndrome Adaptive immune response adjuvant Administered animal model Antibody Response BAL Bronchoalveolar lavage Cell challenge characteristic Chest clinical symptom collected controls coronavirus COVID-19 pandemic CTL CTL epitope downstream analysis Efficacy epitope expression Genome HLA class I immunogenic macaque macaques MHC class I MHC class I peptide microsphere nucleocapsid protein peptide peptide-based vaccine Peripheral blood persistent protection Protective public health recent rhesus macaques SARS-CoV-2 SARS-COV-2 infection sequence variation synthetic synthetic peptide T cell targeting TCID temperature tested the SARS-CoV-2 Transmission unique vaccination Vaccine Vaccines Viral load
[DOI] 10.3390/vaccines9050520 PMC 바로가기 [Article Type] Article

ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques

ACE2 발현은 SARS-CoV-2에 감염된 원숭이에서 AhR에 의해 조절됩니다

Correspondence

Published on 2021-04-012022-09-12
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 진단,

[키워드] ACE2 expression Infection macaque regulated viral infection
[DOI] 10.1038/s41423-021-00672-1 PMC 바로가기 [Article Type] Correspondence

Combination therapy protects macaques against advanced Marburg virus disease

Article

Published on 2021-03-252022-10-04
Journal: Nature Communications [Category] 비임상, 치료제,

Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques following SARS-CoV-2 Vaccination and Infection

Vaccines and Antiviral Agents

Published on 2021-03-102022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] 229E acute respiratory syndrome Antibody Response Betacoronavirus binding common cold coronavirus CoV CoVs cross-react cross-reactive cross-reactivity DNA expressing facilitate full-length spike protein highlight HKU1 Humoral immunity immunization implication induce Infection macaque Neutralizing Neutralizing antibodies Neutralizing antibody response NHPs NL63 observation OC43 other coronavirus other coronaviruses pandemic polyclonal profile pseudoviruses RBD reactivity Receptor binding domain response rhesus macaque rhesus macaques robust sarbecovirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum similarity Spike protein Spike proteins the SARS-CoV-2 the vaccine vaccination Vaccine Vaccines was reduced
[DOI] 10.1128/JVI.00117-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

변형된 백시니아 Ankara 벡터 기반 백신은 SARS-CoV-2 감염, 면역 병리 및 폐 기능 장애로부터 원숭이를 보호합니다.

Article

Published on 2021-03-092022-09-11
Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] abnormality acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach B cell Blood CD8 CD8 T cells Combination coronavirus COVID-19 dysfunction expressing immune induce Infection Inflammation interferon-stimulated genes intranasal lung lung cell lung cells Lungs macaque macaques mice Modified Vaccinia Ankara Neutralizing antibodies neutralizing antibody Neutralizing antibody response pandemic pathology pre-fusion PROTECT protection respiratory rhesus macaques RNA sequencing SARS-CoV-2 SARS-COV-2 infection secreted severe acute respiratory syndrome Coronavirus spike T cell T cell responses T cells the lungs a vaccination Vaccine vaccine candidate vaccinia vector virus replication
[DOI] 10.1016/j.immuni.2021.02.001 PMC 바로가기 [Article Type] Article

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Article

Published on 2021-03-052022-10-04
Journal: Communications Biology [Category] SARS, 유전자 메커니즘,

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Article

Published on 2021-03-042022-10-31
Journal: Cell [Category] COVID-19, Fulltext, SARS,

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Article

Published on 2021-03-032022-10-29
Journal: Nature Communications [Category] COVID-19, SARS,

Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques

Article

Published on 2021-03-022022-10-29
Journal: Nature Communications [Category] COVID-19, SARS,

[키워드] Administered affected alveolar epithelium Bronchoalveolar lavage fluid Candidates clearance clinical development clinical trial COVID-19 pandemic days post-infection develop effective vaccine Efficacy exhibited FIVE four group groups Health histopathological IgG immunized immunogenicity immunohistochemistry inactivated Inactivated Vaccines India interstitial pneumonia lung tissue macaque Macrophage nasal swab Neutralizing antibody titer no evidence of overcome pandemic phase Placebo Pneumonia Preclinical research Protective public health rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 vaccine second dose the placebo group the vaccine three group throat swab Vaccine vaccine candidate Viral antigen viral infection
[DOI] 10.1038/s41467-021-21639-w PMC 바로가기 [Article Type] Article