The SARS-CoV-2 main protease M pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cellsArticle Published on 2021-10-212022-10-04 Journal: Nature Neuroscience [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome animal models block blood-brain barrier Brain Capillaries cause cell death Central nervous system infections changes in cleavage cleave cleaving coronavirus Coronavirus disease 2019 COVID-19 death Deletion Endothelial cell Evidence Germany individual induce inhibitor Lubeck M pro membrane mice NEMO Neurological symptoms nuclear Occurrence pathology patients with COVID-19 pharmacological potential mechanism potential therapeutic target prevented protease Protein Regulated cell death representing SARS-CoV-2 SARS-CoV-2 main protease Signaling small vessel Symptoms treat undergo Vascular vessel [DOI] 10.1038/s41593-021-00926-1 PMC 바로가기 [Article Type] Article
Infection of Human Cells by SARS-CoV-2 and Molecular Overview of Gastrointestinal, Neurological, and Hepatic Problems in COVID-19 PatientsReview Published on 2021-10-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 alteration angiotensin-converting enzyme-2 Brain cell receptors coronavirus disease 19 COVID-19 COVID-19 patient Diseases disorder events Evidence explained expression Gastrointestinal gastrointestinal tract Gut gut flora help hepatic hepatic derangements higher risk Host Human infected with SARS-CoV-2 Infection intestinal permeability likelihood liver liver cells Lungs manifestation Microbiome molecular mechanism neurological Neurological symptoms overexpressed pandemic Pathogens pathophysiological problem recent receptor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spike protein suggested [DOI] 10.3390/jcm10214802 PMC 바로가기 [Article Type] Review
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial CellsSARS-COV-2의 스파이크 단백질은 뇌 내피 세포에서 분자 전달 및 대사 기능에서 병리학 적 변화를 유도한다.Article Published on 2021-10-082022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 BBB Blood–brain barrier Brain cause change changes in component components coronavirus coronavirus disease COVID-19 delivery dextran drastic Effect Endothelial cell endothelial cells enzyme Express function functional host cells induce infected with SARS-CoV-2 infecting infectious agent infectious agents marker mechanism metabolic metabolic function metabolism mitochondrial molecular neurological sign neurological signs Neurological symptom Neurological symptoms pathogenic pathological pathological mechanism permeability physiological RBD recent receptor Receptor-binding domain respiratory S1 domain SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown spike Spike protein the receptor-binding domain toxic effect toxic effects Transferrin Treatment trimer was increased [DOI] 10.3390/v13102021 PMC 바로가기 [Article Type] Article
Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity뇌척수액의 중추신경계 손상에 대한 바이오마커는 COVID-19에서 상승하고 신경학적 증상 및 질병 중증도와 관련이 있습니다Article Published on 2021-10-012022-09-11 Journal: European journal of neurology [Category] MERS, SARS, 바이오마커, 진단, [키워드] Acidic Altered mental status Analysis autoantibody Biomarker Biomarkers Central nervous system cerebrospinal fluid CNS consciousness coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critical CSF demonstrated disease severity elevated examined Extensive feature GFAp headache hospitalized patient hospitalized patients Immunoglobulin Immunoglobulin G Increased Injury intensive care level of consciousness light chain Mild neurological neurological manifestation neurological manifestations Neurological symptom Neurological symptoms NfL pathological finding pathological findings pathology Patient patients patients with COVID-19 plasma pleocytosis Protein reported SARS-CoV-2 small sample size total tau. Two patient two patients was performed weakness [DOI] 10.1111/ene.14703 PMC 바로가기 [Article Type] Article
Neurochemical biomarkers to study CNS effects of COVID-19: A narrative review and synthesisCOVID-19의 CNS 효과를 연구하기 위한 신경화학적 바이오마커: 서술적 검토 및 합성Review Published on 2021-10-012022-09-11 Journal: Journal of neurochemistry [Category] MERS, 바이오마커, [키워드] acute COVID-19 acute infection acute phase addition Anosmia Autopsy Biomarker Blood blood-brain barrier caused Cell Central nervous system cerebrospinal fluid cerebrospinal fluid. characteristic Clinical management Clinical sign Clinical signs CNS common consequence contribute COVID-19 CSF diagnostic diffuse dysfunction Effect Encephalopathy Evidence evidence of hypotheses immune activation include individual Injury Interaction microvascular injury Mild nasal Neurochemical neurologic neurological Neurological symptom Neurological symptoms Neuron neurotropic observation occur Occurrence olfactory Patient patients with COVID-19 perivascular perivascular cells pleocytosis prognostic recovering from COVID-19 reported Research SARS-CoV-2 SARS-COV-2 infection severe COVID-19 supported supporting cells Symptom syndrome systemic inflammatory the disease thromboembolic Thromboembolic event Thromboembolic events tissue tissues treat Viral viral infection viral infections virus detection [DOI] 10.1111/jnc.15459 PMC 바로가기 [Article Type] Review
A wide spectrum of neurological manifestations in pediatrics patients with the COVID-19 infection: a case seriesCOVID-19 감염 소아과 환자의 광범위한 신경학적 징후: 사례 시리즈Case Reports Published on 2021-10-012022-09-11 Journal: Journal of Neurovirology [Category] SARS, 치료기술, [키워드] acetazolamide Case series case sery checked children clinical Clinical data COVID-19 COVID-19 patient CSF Dengue described electronic medical records epilepsy Guillain-barrè syndrome heterogeneous highlight human immunoglobulin hypertension idiopathic Idiopathic intracranial hypertension Immunoglobulin Intracranial Hypertension Lumbar puncture male manifestation Manifestations measure mild symptoms nervous system neurologic neurological manifestation neurological manifestations Neurological symptom Neurological symptoms outcome participant Patient pediatric Pediatric patient Peripheral nervous system Polyradiculoneuropathy reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection Seizure Symptom Symptoms Treatment with COVID-19 [DOI] 10.1007/s13365-021-01004-9 PMC 바로가기 [Article Type] Case Reports
Long-Term Neurological Impact of COVID-19Internal Medicine Published on 2021-09-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Anosmia Brain Care carried Central nervous system Clinical management clinician cns disorders complicate complications coronavirus disease COVID-19 discharged disease disorders drug interaction Effect enrolled Enrollment females Follow-up headache highlight hospital Impact include increased risk Inflammatory Insomnia Loss of Smell male management medication neurologic neurological Neurological disorder neurological outcomes Neurological symptoms participant Patient patients with COVID-19 Potential recent reported Research Respiratory system sars-cov-2 (severe acute respiratory syndrome coronavirus -2) sense of smell Spread stroke Symptom treat [DOI] 10.7759/cureus.18131 PMC 바로가기 [Article Type] Internal Medicine
Cognitive and Psychological Sequelae of COVID-19: Age Differences in Facing the PandemicPsychiatry Published on 2021-09-162022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Adults Affect age age differences applied assessment association Care checklist Clinical characteristics cognitive cognitive effects conducted cough COVID-19 COVID-19 pandemic difference Effect evaluate Hospitalization ICU individual Infection intensity intensive care Intubated involved Linear regression model literature Montreal Neurological symptoms Neuropsychiatric Older pandemic participant persistence Post-traumatic stress disorder predicted Psychological Psychological assessment receiving Separate socio-demographic whole sample [DOI] 10.3389/fpsyt.2021.711461 PMC 바로가기 [Article Type] Psychiatry
Potential Cross-Links of Inflammation With Schizophreniform and Affective Symptoms: A Review and Outlook on Autoimmune Encephalitis and COVID-19Psychiatry Published on 2021-09-162022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] addition Affective disorder Autoimmune encephalitis biological interaction Brain caused Clinical practice COVID-19 Diagnosis Effects immune system implication infections Inflammation mental health mental illness Neurological symptoms pandemic Potential review SARS-CoV-2 schizophreniform disorder the SARS-CoV-2 the SARS-CoV-2 virus therapy viral entry [DOI] 10.3389/fpsyt.2021.729868 PMC 바로가기 [Article Type] Psychiatry
Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID-19 neuropathy patientsCOVID-19 신경병증 환자의 급성 및 회복기 동안 뇌척수액 및 혈청 인터루킨 6 및 8Case Reports Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 진단, [키워드] absence action potential acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Admission affected amplitude Analysis case sery cerebrospinal fluid clinical Clinical symptoms complete recovery Complication conduction block coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis electroneurography elevated F waves IL-6 IL-8 Immunoglobulin Inflammation Inflammatory response interleukin interleukin-6 Interleukins Intravenous immunoglobulin nervous system neurological Neurological symptoms Patient Peripheral nervous system polyradiculoneuritis polyradiculonevritis Prognosis prognostic biomarker Prognostic biomarkers remained respiratory serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant decrease Symptom syndrome Therapeutic approach was tested were measured [DOI] 10.1002/jmv.27061 PMC 바로가기 [Article Type] Case Reports