Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-κB pathway in porcine intestinal epithelial cell lineResearch Article Published on 2018-10-122022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] activate Activation Analysis analyzed binding cell line cells circular RNA differentially expressed Effects epithelial epithelial cell line expressed gastroenteritis Infection Inflammation inhibited Interaction intestinal intestinal epithelial cell KEGG Kyoto microRNA miRNA miRNAs mitochondrial mRNA mRNAs ncRNA ncRNAs Next-generation sequencing NF-κB NF-κB pathway NGS non-coding RNA nucleus opposite overexpression p65 pathway Pathways Phosphorylation profile promoted Protein receptor reduction regulate reporter Result RNA severe inflammation supplementary material TGEV TNF translated transmissible gastroenteritis virus viral infection virus was used [DOI] 10.1186/s12864-018-5128-5 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell deathArticle Published on 2018-09-052022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, MERS, [키워드] activate addition Apoptotic cell death autophagy caspase-1 cause clinical manifestation contributing to dysfunction Effect Factor Genes helping implicated interact lysosomal lysosomal membrane membranes molecular mechanism necrotic cell death NLRP3 inflammasome assembly nucleus occur oligomerization Open reading frame pathophysiologic pathway Pathways Potassium Protein reading SARS-CoV SARS-CoV infection severe lung pathology target TFEB Transcription translocate Trigger while [DOI] 10.1038/s41419-018-0917-y PMC 바로가기 [Article Type] Article
Cellular hnRNP A1 Interacts with Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus and Impairs Viral ReplicationArticle Published on 2018-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] cells cellular cytoplasm demonstrated epidemic diarrhea expression heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) in viral in vivo infected cells Infection inhibited multifunctional protein N protein nuclear nucleocapsid nucleocapsid protein nucleus PEDV porcine epidemic diarrhea virus (PEDV) positive pre-mRNA predicted Protein proteomic study Regulation Replication ribonucleoprotein thought translation virus [DOI] 10.3390/v10030127 PMC 바로가기 [Article Type] Article
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infectionResearch Article Published on 2018-01-252022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accessory gene accessory protein acute respiratory distress antiviral response antiviral signaling ARDS binding contribute coronavirus CoV cytoplasm cytoplasmic Evidence expressed expression Fatality rate highly pathogenic host protein human CoV human infections indicate infected cells Infection information inhibited inhibiting innate immune response Interaction interfere involved Isolation KPNA4 mechanism MERS-CoV Middle East mutant NF-κB NLS nuclear nuclear localization signal nucleus pathology Pathways Prevent pro-inflammatory cytokines Protein protein complex Proteins required respiratory syndrome coronavirus retained robust severe pneumonia shown subunit syndrome translocated translocation Transport wild-type virus [DOI] 10.1371/journal.ppat.1006838 PMC 바로가기 [Article Type] Research Article
Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article
The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cellsResearch Article Published on 2017-03-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions Zoonotic coronavirus [DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article
Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV GrowthArticle Published on 2017-01-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] activities addition binding caspase-3 Cell components cytoplasm Degradation ENhance Enhancing epidemic diarrhea growth host cell independent indicated infected cells interact Interaction knockdown mechanism N protein NPM1 nuclear translocation nucleocapsid Nucleolus nucleophosmin nucleus overexpression PEDV Prevent promoted PROTECT Protein proteolytic proteolytic cleavage Regulation replicate Replication required suppressed survival the N protein virus [DOI] 10.1038/srep39700 PMC 바로가기 [Article Type] Article
The nucleolar protein GLTSCR2 is required for efficient viral replicationArticle Published on 2016-11-082022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated attenuate blocking cells cellular contributed coronavirus cytoplasm cytoplasmic glioma host cell IFN-β Infection innate immune response NES nuclear nucleus protease Protein required RIG-I sequence suggested Support supported therapeutic translocation triple interaction tumor suppressor type I interferon USP15 viral infection viral replication [DOI] 10.1038/srep36226 PMC 바로가기 [Article Type] Article
Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.Research Article Published on 2016-10-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence [DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article