Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells중증 코로나19에서 증가된 오토탁신 수치, IL-6 수치, 내피 기능 장애 바이오마커 및 수지상 세포 기능 손상과 상관관계Article Published on 2021-09-162022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] ARDS Autotaxin autotaxin (ATX; ENPP2) Biomarkers cohorts correlated COVID-19 COVID-19 pathogenesis COVID-19 patients Cytokine storm dataset dendritic cells dendritic cells (DCs) Dexamethasone endothelial damage ENPP2 expression Extracellular fibrosis function functional homeostasis Hospitalization hyperinflammation IL-6 Immune cell immune cells Impaired include Increased independent Inflammation Level LPA lysophosphatidic acid (LPA) mechanically ventilated mechanically ventilated patient mechanically ventilated patients mRNA level multifunctional Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples pathologic pharmacological pleiotropic pulmonary fibrosis pulmonary injury reduced RNA sequencing scale analysis secreted Serum level severe COVID-19 patients shown Signaling Single Cell suggested suppression Therapeutic benefit therapeutic benefits therapeutic option Treatment vascular dysfunction [DOI] 10.3390/ijms221810006 PMC 바로가기 [Article Type] Article
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunctionCOVID-19는 내피 장벽 기능 장애를 직접 유도하는 히알루로난 단편을 생성합니다Research Article Published on 2021-09-082022-09-12 Journal: JCI Insight [Category] 진단, [키워드] activity analyzed CD44 circulating circulation Clinical severity Complication contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critical illness damaged Degradation degrade disease dysfunction dysregulated endothelial Endothelial cell enzyme Enzymes Evidence exacerbating Extracellular matrix functions generate glycobiology glycocalyx glycosaminoglycan Hyaluronan hyaluronidase induce Inflammatory cytokine Injury moderate moderate to severe morbidity Organ failure pathologic pathology patients with COVID-19 plasma Protective provide pulmonary regulate released Sepsis Severity of disease significantly Vascular Vascular Biology Vascular injury [DOI] 10.1172/jci.insight.147472 PMC 바로가기 [Article Type] Research Article
Disseminated intravascular coagulation and its immune mechanismsResearch article Published on 2021-08-242022-10-05 Journal: Blood [Category] 비임상, [키워드] Activation Algorithm amplified Anticoagulant bleeding Blood coagulation Care characterized clinical clinical manifestation Coagulopathies Consumption consumptive Contact Critical Damage-associated molecular patterns Diagnosis disseminate dysregulation endothelial etiology Excessive activation expression fibrinogen homeostasis immune mechanism increased mortality Inflammatory Initiation intravascular coagulation mechanisms Microvascular thrombosis morbidity Mortality overlapping pathogenic mechanism pathologic pathology pathway Patient proteolytic reducing Regulatory supportive care syndrome thrombin tissue Trigger triggered vasculature widespread worsening [DOI] 10.1182/blood.2020007208 [Article Type] Research article
The Microvillar and Solitary Chemosensory Cells as the Novel Targets of Infection of SARS-CoV-2 in Syrian Golden HamstersArticle Published on 2021-08-202022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] activated acute respiratory syndrome angiotensin-converting enzyme 2 apoptotic cell basal cells Cell cells cellular components change chemosensory contribute coronavirus coronavirus disease damaged determine epithelia expression hamster Infection infiltration inflammatory cells influence Loss of Smell microenvironment microvillar cell nasal novel olfactory Olfactory epithelium olfactory function Olfactory system organ pathologic pathological change receptor protein reduced regeneration SARS-CoV-2 second solitary chemosensory cell Structure Symptoms Syrian golden hamster Syrian Golden hamsters target these symptoms viral infection vomeronasal were used [DOI] 10.3390/v13081653 PMC 바로가기 [Article Type] Article
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses통합 생물정보학 분석을 기반으로 한 COVID-19 및 뎅기열 숙주 인자 상호작용 네트워크 식별Immunology Published on 2021-07-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] addition Analysis bioinformatics bioinformatics analyses Biological functions biological process build candidate drug candidate drugs categories CCL2 CCL4 Clinical practice Co-infection conducted contribute coronavirus disease Coronavirus disease 2019 COVID-19 Dengue Dexamethasone drug dysregulated enrichment analysis expressed Factor Genes Genistein Health crisis Host host factor interaction networks ICAM-1 identification identify IL-1 Interaction international public health Intervention lung management mechanism molecular Molecular Complex Detection network outbreak pathologic pathway performed potential therapeutic agents potential therapeutic target potential therapeutic targets PPI probe protein-protein interaction provide raised receptor signaling respiratory Respiratory disease Result resveratrol screened signaling pathway signaling pathways significant effect significant pathways target therapeutic agents TNF-α Toll-like receptor Treatment upregulated gene upregulated genes [DOI] 10.3389/fimmu.2021.707287 PMC 바로가기 [Article Type] Immunology
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators런트 관련 전사 인자 1을 표적으로 하여 폐 섬유증을 예방하고 중증 급성 호흡기 증후군의 발현을 감소시킵니다 코로나바이러스 2 숙주 매개체Article Published on 2021-07-012022-09-12 Journal: The American journal of pathology [Category] MERS, 신약개발, 진단, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 causes coronavirus coronavirus 2 Critical current Disease progression downstream expression Factor FES fibroblasts fibrosis growth host protein human lung in vitro infections Inflammation inhibitor Lung epithelial cells Lung fibrosis mechanism mediator mice overexpress pathologic patients with HIV Pleiotropic effects pulmonary reduced reducing Region respiratory Respiratory complications Ro24-7429 RUNX1 Safe SARS-CoV-2 SARS-COV-2 infection subset targeting transcription factor Treatment tumor necrosis factor-α vascular endothelial cells [DOI] 10.1016/j.ajpath.2021.04.006 PMC 바로가기 [Article Type] Article
How safe are children with COVID-19 from cardiac risks? Pediatric risk assesment; insights from echocardiography and electrocardiographyCOVID-19에 감염된 어린이는 심장 위험으로부터 얼마나 안전합니까? 소아 위험 평가; 심장초음파 및 심전도에서 얻은 통찰력Article Published on 2021-06-282022-09-12 Journal: Turkish Journal of Medical Sciences [Category] MERS, SARS, 진단, [키워드] affected arrhythmia cardiac effect children children with COVID-19 control group control groups coronavirus disease COVID patient Covid patients COVID-19 COVID-19 infections COVID‐19 determine diastolic dysfunction ECG echocardiographic parameters Effect Ejection fraction electrocardiographic Electrocardiography evaluated FIVE Hospitalized individual infected with SARS-CoV-2 Infection information Laboratory less material Mild Misconception mitral mitral insufficiency Myocardial function no significant difference Novel coronavirus novel coronavirus disease parameters pathologic Patient required responsible Result risk Safe significantly increased significantly lower the patient thought transthoracic echocardiography Treatment troponin troponin levels TTE virus with COVID-19 [DOI] 10.3906/sag-2010-240 PMC 바로가기 [Article Type] Article
Lung-Centric Inflammation of COVID-19: Potential Modulation by Vitamin DCOVID-19의 폐 중심 염증: 비타민 D에 의한 잠재적 조절Review Published on 2021-06-282022-09-12 Journal: Nutrients [Category] MERS, SARS, 진단, [키워드] acute respiratory distress syndrome (ARDS) addressed Antiviral Autopsy coronavirus COVID-19 COVID-19 pathogenesis Cytokine storm death Defense Evidence excessive inflammatory response immunothrombosis indicate infect Infection Inflammasome initial kidney lung Lung inflammation neutrophil extracellular traps (NETs) organ organs pathologic Potential Respiratory failure respiratory tract SARS-CoV-2 specimen the disease the lungs a therapy Vitamin D [DOI] 10.3390/nu13072216 PMC 바로가기 [Article Type] Review
Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?중증 COVID-19에 대한 덱사메타손: 세포 및 분자 수준에서 어떻게 작용합니까?Review Published on 2021-06-232022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] accompanied activity anti-inflammatory property Bacterial sepsis cause caused characteristic coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 develop Dexamethasone Diseases effective encoding proteins facilitate glucocorticoid glucocorticoid dexamethasone glucocorticoid receptor (GR) Glucocorticoids host cell Hypothesis hypothetical impacted infected cells Infection Infectious diseases Inflammation Influenza influenza pneumonia Innate immunity interfere life-threatening Local mechanism modulated modulating non-infected not affect pathologic Pneumonia potential molecular Protein Replication reported respiratory Respiratory failure respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection Sepsis Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe COVID-19 severe respiratory syndrome significantly steroid systemic inflammation Treatment type I interferons (IFNs) unique Viral Viral diseases viral replication virus viruses work [DOI] 10.3390/ijms22136764 PMC 바로가기 [Article Type] Review
Viral Bad News Sent by EVAILReview Published on 2021-06-182022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] activities Alternative pathway Antiretroviral therapy body fluid cardiovascular complications cardiovascular disease cardiovascular dysfunction cause chronic infection cytokine demonstrated disseminate dysfunction endothelial Endothelial cell EVs example Exosomes explain extracellular vesicle Extracellular vesicles highlight HIV HIV patient host response Human immunodeficiency virus knowledge load Nef New pathologic Pathologies proinflammatory Protein SARS-CoV-2 Sent Vascular vascular endothelial cells viral infection virus [DOI] 10.3390/v13061168 PMC 바로가기 [Article Type] Review