positive rate – Page 7 – Communicable Diseases Research

Different Profiles of Antibodies and Cytokines Were Found Between Severe and Moderate COVID-19 Patients

중증 및 중등도의 COVID-19 환자 사이에서 항체 및 사이토카인의 다양한 프로필이 발견되었습니다

Immunology

Published on 2021-08-192022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법,

[키워드] anti-S anti-S protein antibodies anti-S protein antibody antibody Antibody titer Antibody titers CCL2 Concentration COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical CXCL10 cytokine cytokine profile Cytokine storm Cytokines determine determined by distribution ELISA enrolled healthy individuals IFN-γ IgA IgE IgG IgG antibodies IgG subclasse IgG subclasses IgG3 IgG4 IgM IL-10 IL-2 IL-4 IL-6 Immunoglobulin immunoglobulin type in healthy individuals less live SARS-CoV-2 Mann-Whitney moderate N and S proteins Neutralization assay neutralizing antibody neutralizing antibody titers objective Patient patients positive positive rate positively correlated profile Protein Result S protein S proteins Sample SARS-CoV-2 severe COVID-19 Severe patient severe patients severity significant difference significantly significantly higher significantly more t-test T-tests tested titer TNF-α were measured with COVID-19
[DOI] 10.3389/fimmu.2021.723585 PMC 바로가기 [Article Type] Immunology

Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody

MW33의 안전성, 내약성, 약동학 적 특성 및 면역 원성 : SARS-COV-2 RBD- 표적 모노클로 날 항체의 1 상 임상 연구

Clinical Trial

Published on 2021-08-182022-08-13
Journal: Emerging Microbes & Infections [Category] SARS, 임상, 진단, 치료제,

[키워드] adverse event adverse events AEs Antibody titre antibody titres AUC C max clinical study Concentration concentration-time curve conducted coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated Diseases disorders dose dose-escalation double-blind enrolled evaluate Evidence evidence of follow-up period fully humanized IgG1κ monoclonal neutralizing antibody GRADE Grade 1 group healthy subjects humanized Identifier immunogenicity incidence Infectious diseases infused Laboratory Laboratory test linear kinetic relationship linear PK maximum concentration monoclonal monoclonal antibody MW33 MW33 injection NCT04427501 neutralizing antibody no evidence of participant pharmacokinetic characteristics pharmacokinetics Phase 1 Phase 1 clinical trial phase 1 study PK parameters Placebo placebo-controlled plasma half-life positive rate positive rates Randomized Safety SARS-CoV-2 serum ADA serum ADAs severity subject the SARS-CoV-2 Tolerability Treatment Trial registration Vascular vascular and lymphatic disorders
[DOI] 10.1080/22221751.2021.1960900 PMC 바로가기 [Article Type] Clinical Trial

Detection of three pandemic causing coronaviruses from non-respiratory samples: systematic review and meta-analysis

Article

Published on 2021-08-092022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,

Analysis of SARS-CoV-2 PCR and Chest CT Findings at a Single Facility in Tokyo (Machida Municipal Hospital)

도쿄의 단일 시설(마치다 시립 병원)에서 SARS-CoV-2 PCR 및 흉부 CT 소견 분석

Research Article

Published on 2021-07-262022-09-12
Journal: Pulmonary Medicine [Category] SARS, 진단,

Emergence of a young case infected with avian influenza A (H5N6) in Anhui Province, East China during the COVID‐19 pandemic

Case Reports

Published on 2021-07-142022-10-04
Journal: Journal of medical virology [Category] MERS, SARS, 변종, 조류인플루엔자, 치료기술,

A novel index-based decision support toolkit for safe reopening following a generalized lockdown in low and middle-income countries

Article

Published on 2021-07-082022-10-29
Journal: Scientific Reports [Category] COVID-19,

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

Article

Published on 2021-07-062022-10-04
Journal: Nature Communications [Category] SARS, 임상, 치료기술, 치료법,

[키워드] acute respiratory syndrome Adaptive immunity age antibodies antibody Antibody Response Antibody titer Antimicrobial responses convalescent convalescent COVID-19 patient convalescent plasma coronavirus coronavirus disease COVID-19 COVID-19 pandemic decrease Diagnosis domain Donor exceeded facilitate female Health humoral immune response IgG antibody IgG response immune memory Immunity initial male Neutralizing antibody titer older patient patients plasma plasma sample positive correlation positive rate promote reduce responses risk SARS-CoV-2 Spike protein the patient therapy Vaccine viral infection Wuhan Wuhan, China
[DOI] 10.1038/s41467-021-24230-5 PMC 바로가기 [Article Type] Article

Evaluation of a Rapid Antigen Test To Detect SARS-CoV-2 Infection and Identify Potentially Infectious Individuals

SARS-CoV-2 감염을 감지하고 감염 가능성이 있는 개인을 식별하기 위한 신속한 항원 검사 평가

Virology

Published on 2021-07-022022-09-10
Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 치료기술,

Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19

Review

Published on 2021-06-302022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis Case series children Clinical characteristics clinical study Complete conjunctivitis coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 cases epidemiological feature Fever FIVE immune dysregulation Inflammatory Kawasaki disease Laboratory manifestation Meta-analysis MIS-C Multisystem inflammatory syndrome nasopharyngeal neurological Pathogenesis Patient peer-reviewed polymerase chain positive rate predominant proportion Rash real-time reverse transcriptase RT-PCR SARS-CoV-2 searched serology serum antibody Shock syndrome systemic systemic manifestation the patient were recorded with COVID-19
[DOI] 10.3390/jcm10132953 PMC 바로가기 [Article Type] Review

Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors

나노플라즈몬 바이오센서를 활용한 SARS-CoV-2 감염의 RNA/스파이크 단백질/IgG/IgM 바이오마커의 다중 및 고처리량 무표지 검출

Article

Published on 2021-06-292022-09-11
Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody applied approach Biomarker biosensor calculated caused Characteristics clinician coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic detect detection diagnostic diagnostic test diagnostic tests diagnostics disease effective Genes healthy individual healthy individuals IgG and IgM IgM antibodies Infection limit of detection Mann-Whitney nonparametric MOST multiplex Negative predictive value nonparametric test P -value Patient plasma sample plasma samples platform Positive predictive value positive rate Predictive value Prevalence progression proof proof of concept provide receiving respiratory responses SARS-CoV-2 screening test sensitivity severe acute respiratory syndrome Coronavirus severity specificity Spike protein Stage subunits Treatment true negative true positive rate unmet need Viral viral nucleic acid virus
[DOI] 10.1021/acs.analchem.0c05300 PMC 바로가기 [Article Type] Article