High Mobility Group Box 1 and Interleukin 6 at Intensive Care Unit Admission as Biomarkers in Critically Ill COVID-19 Patients중환자 단위에서 고도리 그룹 박스 1 및 인터루킨 6은 중환자 실에 입원하여 중환자가 아픈 Covid-19 환자에서 바이오 마커로Articles Published on 2021-07-032022-09-10 Journal: The American Journal of Tropical Medicine and Hygi [Category] SARS, 바이오마커, [키워드] “cytokine storm” Accuracy Acute kidney injury Admission age Analysis analyzed assessment Biomarkers Box C-reactive protein Comorbidities Comorbidity comparable coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients COVID-GRAM Critically ill critically ill COVID-19 patients Cytokine storm D-dimer levels discharge elevated enrolled Exuberant failure Gender group healthy control HMGB1 ICU ICU admission ICU patient IL-6 IL-6 level IL-6 levels IL6 Ill Inflammation intensive care intensive care unit interleukin interleukin 6 interleukin-6 investigated Mobility Mortality neutrophil nonsurvivor PaO Pathogenesis Patient plasma Plasma HMGB1 Plasma levels poor oxygenation predicted prognostic prognostic biomarker Prognostic biomarkers Prognostic markers prospective cohort study risk Septic shock severe coronavirus disease severe COVID-19 SOFA SOFA score suggested Survivors Ventilation with COVID-19 [DOI] 10.4269/ajtmh.21-0165 PMC 바로가기 [Article Type] Articles
Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospective analysisResearch Paper Published on 2021-06-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, [키워드] acute respiratory distress acute respiratory distress syndrome Admission analyzed ARDS cause Course COVID-19 COVID-19 patient death Elderly patient elderly patients HFNC high mortality high-flow nasal cannula therapy Hospital stay Hospitalization hospitals ICU illness onset likelihood nasal no significant difference Older Organ failure outcome oxygen PaO Patient patients died receiving Retrospective analysis severe ARDS severely ill patients SOFA Spread suggested syndrome therapy treated viral shedding with COVID-19 [DOI] 10.18632/aging.203224 PMC 바로가기 [Article Type] Research Paper
Obesity May Not Be Associated with 28-Day Mortality, Duration of Invasive Mechanical Ventilation and Length of Intensive Care Unit and Hospital Stay in Critically Ill Patients with Severe Acute Respiratory Syndrome Coronavirus-2: A Retrospective Cohort StudyObservational Study Published on 2021-06-292022-10-04 Journal: Medicina [Category] MERS, SARS, 임상, [키워드] 28-day mortality age all-cause mortality assessment association body mass index correlation critically ill patients Duration Factor failure had no hospital Hospital stay ICU Ill independent intensive care unit Invasive mechanical ventilation investigated Kaplan–Meier Length Length of stay log rank material Mechanical multivariate Cox regression obesity Observational cohort study Patient Pneumonia respiratory retrospective RT-PCR SARS-CoV-2 SARS-CoV-2 pneumonia severe acute respiratory syndrome coronavirus-2 significant difference SOFA statistically significant survival the patient [DOI] 10.3390/medicina57070674 PMC 바로가기 [Article Type] Observational Study
Risk factors for mortality in critically ill patients with COVID-19: a multicenter retrospective case-control studyResearch Article Published on 2021-06-242022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission Analysis APACHE II APACHE II score assessment being case-control study chronic Clinical data collected confidence Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill Critically ill patient CRP death death case declining determine enrolled Factor failure hazard ratio identify IL-6 In-hospital death Increasing independent risk factor Inflammation Inpatient interval likelihood Lymphocyte count lymphopenia Mortality multicenter multivariable Cox regression Organ failure paO2/fiO2 Patient patients Physiology poor prognosis positive Result retrospective risk factor Risk factors SARS-CoV-2 SOFA SOFA score Spread supplementary material survival univariable with COVID-19 [DOI] 10.1186/s12879-021-06300-7 PMC 바로가기 [Article Type] Research Article
Predicting lethal courses in critically ill COVID-19 patients using a machine learning model trained on patients with non-COVID-19 viral pneumoniaArticle Published on 2021-06-242022-10-04 Journal: Scientific Reports [Category] MERS, 치료법, [키워드] Accuracy applied AUROC Course courses COVID-19 COVID-19 patient Critical Critically ill Deceased disease early phase ICU Infectious diseases investigated knowledge machine learning Mortality Non-COVID-19 Non-COVID-19 patients pandemic Patient patients predict predicted Predictive Predictive medicine Prognosis significantly SOFA the disease transfer Viral pneumonia [DOI] 10.1038/s41598-021-92475-7 PMC 바로가기 [Article Type] Article
Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill PatientsEndocrinology Published on 2021-06-162022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] Admission APACHE II association Blood calculated control patients controls Critically ill patient Factor Glucose groups growth factor growth hormone hospital Hospitalization humans ICU IGF-1 IGF1 Ill insulin-like growth factor 1 Laboratory laboratory parameter lactate dehydrogenase non-critically ill patient non-survivor normalized objective Older outcome Pandemics Patient Pneumonia prognostic Prognostic value raw data Result SDS severe acute respiratory syndrome coronavirus 2 significant difference SOFA Standard deviation survivor White blood cell [DOI] 10.3389/fendo.2021.644055 PMC 바로가기 [Article Type] Endocrinology
Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosisObservational Study Published on 2021-06-072022-10-04 Journal: Critical Care [Category] MERS, 임상, [키워드] Affect Analysis analyzed Antimicrobial therapy Bacterial Bacterial infection Bronchoalveolar lavage bronchoalveolar lavage sample clinical clinical feature Community controls COVID-19 COVID-19 group COVID-19 patient feature Fold change group hospitalized patient ICU ICU patient Infection initial intensive care IRCCS Italy log lung Lung microbiota mechanical ventilation medical icu microbial community microbiota Mortality multivariable logistic regression non COVID-19 patient Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients Organ failure Patient patients patients with COVID-19 patients without COVID-19 R 2 Result risk Rome SARS-COV-2 infection significantly SOFA Specy Staphylococcus aureus statistically significant difference Streptococcus anginosus study population supplementary material the patient two group Ventilator-associated pneumonia with COVID-19 [DOI] 10.1186/s13054-021-03623-4 PMC 바로가기 [Article Type] Observational Study
Risk Stratification for ECMO Requirement in COVID-19 ICU Patients Using Quantitative Imaging Features in CT Scans on AdmissionArticle Published on 2021-06-032022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 95% CI Admission affected age Analysis artificial intelligence AUC BMI body mass index can be used Computed tomography computed tomography scan Coronavirus disease 2019 COVID-19 COVID-19 patient CT finding CT scan diagnostic ECMO ECMO therapy evaluated Extracorporeal extracorporeal membrane oxygenation feature hospital Hospital admission ICU ICU admission ICUs imaging IMPROVE include intensive care unit IQR Lactate Logistic regression lung lung involvement management median time membrane Organ failure Oxygenation parameter Patient patient data predict receiver operating characteristic Requirement resource Respiratory distress syndrome risk stratification ROC sensitivity severe COVID-19 disease Sex significantly significantly higher significantly lower single-center study SOFA SOFA score specificity subsequent therapy Treatment [DOI] 10.3390/diagnostics11061029 PMC 바로가기 [Article Type] Article
Transpulmonary pressure measurements and lung mechanics in patients with early ARDS and SARS-CoV-2Observational Study Published on 2021-06-012022-10-05 Journal: Journal of critical care [Category] SARS, 임상, [키워드] acute respiratory distress syndrome acute respiratory syndrome ARDS BMI Boston center Characteristics Chest Chest wall Chest wall mechanics clinical cohorts Compliance coronavirus Coronavirus-2 correlated COVID-19 Critically ill Deaconess demonstrated distress heterogeneity inherent lung lung mechanics Massachusetts Mechanical mechanical ventilation Mechanics moderate-severe Mortality Oxygenation PaO Patient patients with SARS-CoV-2 pleural pressure remained required respiratory Respiratory system SARS-CoV-2 SOFA transpulmonary pressure was collected were measured [DOI] 10.1016/j.jcrc.2021.02.005 PMC 바로가기 [Article Type] Observational Study
High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumoniaArticle Published on 2021-05-242022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, [키워드] acute phase response Analysis association body mass index C-reactive protein Comorbidity Concentration concentrations correlated COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients Cytokines dysregulated immune response enrolled Fatty acid feature form HDL High-density lipoprotein cholesterol hospitalized patient Immunopathogenesis Infection initial intensive care lipoprotein metabolism metabolic disorder MOST NEFA Non-COVID-19 obese patients Organ failure outcome Pathogenesis patients hospitalized plasma plasma concentration Pneumonia Polyunsaturated PUFA required respiratory severity Sepsis Severe COVID-19 pneumonia severe pneumonia SOFA therapeutic targets to define unique Ventilator-free days were assessed with COVID-19 [DOI] 10.1038/s41598-021-90362-9 PMC 바로가기 [Article Type] Article