Antiviral drugs against influenza: Treatment methods, environmental risk assessment and analytical determinationReview article Published on 2022-09-012022-10-05 Journal: Journal of environmental management [Category] 치료제, [키워드] addition Adsorption Antiviral antiviral drug Antiviral drugs against influenza approach biological processes Characteristics Coagulation Combined Concentration concentrations contaminant Contamination COVID-19 drug Ecotoxicological risk Effect Effects evaluated filtration indicated Influenza investigated metabolite metabolites over Perspective plant Prevent required Research risk tested Toxicity Treatment Wastewater treatment were assessed [DOI] 10.1016/j.jenvman.2022.115523 [Article Type] Review article
First-generation oral antivirals against SARS-CoV-2Review article Published on 2022-09-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral agent Clinical practice clinical trials Compliance content coronavirus COVID-19 death drug drug-drug interaction early administration Efficacy Emergency use authorization Frequency Google Scholar high risk Hospitalization Hospitalized Immunosuppressed include individual ingestion Mild-to-moderate molnupiravir Nirmatrelvir objective oral Patient persistence progression reduced reference Regulatory required risk reduction Ritonavir SARS-CoV-2 Source Toxicity Treatment website [DOI] 10.1016/j.cmi.2022.04.015 [Article Type] Review article
In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspectiveArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 신약개발, [키워드] absence acute respiratory syndrome alkaloids analyzed anti-SARS-CoV-2 approach approved assist binding binding energy caused Clinicians Compound computer-aided drug design contribute coronavirus COVID-19 death derivative determine Diseases drug candidate drug design Drug discovery drugs effective facilitate highest in silico Ligand mechanism Medicines natural natural products Perspective pharmacological physician phytochemical Practitioner public health RdRP reported Research researcher researchers RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 main protease subsequent therapeutic Therapeutic approach therapeutic molecules therapeutic target took place Toxicity Treatment vaccination viral replication Virtual screening [DOI] 10.3389/fcimb.2022.929430 PMC 바로가기
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes Research Published on 2022-08-172022-10-05 Journal: Communications Biology [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 attenuate cause coronavirus COVID-19 COVID-19 patients cytopathic effects Deprivation Evidence exacerbated expressed expressing Fatty liver full-length Glycolysis hACE2 hepatic dysfunction hepatocyte hepatocytes Human humanized hyperglycemia immune response include increase Infection infection with SARS-CoV-2 Inflammation inhibition Injury metformin methionine mice mitochondrial Multi-organ damage Patient promote pseudotyped viral particles pseudovirus RBD Receptor binding domain reduce renin-angiotensin system SARS-CoV-2 steatosis susceptibility susceptible therapeutic option Toxicity type 2 diabete viral particle [DOI] 10.1038/s42003-022-03789-9 [Article Type] Research
New Perspectives on Antimicrobial Agents: Molnupiravir and Nirmatrelvir/Ritonavir for Treatment of COVID-19항균제에 대한 새로운 관점: 코로나19 치료를 위한 몰누피라비르 및 니르마트렐비르/리토나비르Article Published on 2022-08-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted relative risk antimicrobial Antiviral cause childbearing potential children Complication Contraception coronavirus disease Coronavirus-2 COVID-19 cytochrome P450 Cytochrome P450 enzymes death drug Drug administration Drug-to-drug interaction Each Emergency use authorization food hospitalizations in vitro inhibit limit management medication metabolism Mild mild to moderate moderate molnupiravir morbidity and mortality Mutation New Nirmatrelvir Nirmatrelvir/ritonavir nonspecific outcome pandemic Patient polymerase polyprotein pregnant protease proteolytic cleavage reduction Relative risk Replication Respiratory disease risk Ritonavir SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly target tested Toxicity Treatment treatment regimen U.S. Food and Drug Administration variant viral replication virus virus production [DOI] 10.1128/aac.02404-21 PMC 바로가기 [Article Type] Article
Identification of 1,2,3-triazole-phthalimide derivatives as potential drugs against COVID-19: a virtual screening, docking and molecular dynamic studyCOVID-19에 대한 잠재적 약물로서의 1,2,3-트리아졸-프탈이미드 유도체 식별: 가상 스크리닝, 도킹 및 분자 역학 연구Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] 123-triazole addition AMES test Analysis Antiviral be positive binding energy calculated complex Compound derivative derivatives docking drug drug candidate drug candidates E35 energy balance exhibited filtered hepatotoxic identification identify in silico inhibitory Interaction investigated M pro MD simulation molecular molecular docking Nucleocapsid proteins other compound other compounds pharmacokinetic phthalimide positive Predictive Prophylaxis protease SARS-CoV-2 SARS-CoV-2 main protease selected target protein target proteins Toxicity toxicity test Treatment triazole Virtual screening [DOI] 10.1080/07391102.2020.1871073 PMC 바로가기 [Article Type] Article
Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped virusesArticle Published on 2022-08-012022-11-15 Journal: Phytotherapy research : PTR [Category] SARS, 치료제, [키워드] ACE2 receptor ADA Antiviral antiviral activity antivirals antivirals. approach blocked caused complementary COVID-19 pandemic death drug candidate effective drugs evaluated H5N1 HIV-1 Host indicated inhibited inhibitor inhibitory activity plant pseudotyped pseudovirus responsible Safe SARS-CoV-1 SARS-CoV-1 and 2 SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoVs Spatholobus suberectus Dunn target cell Toxicity treating COVID-19 Treatment viral entry virus viruses [DOI] 10.1002/ptr.7452 PMC 바로가기
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™SARS-COV-2 항바이러스 치료제 Paxlovid™의 적시 개발을 지원하는 Nirmatrelvir의 포괄적인 비임상 안전성 평가Article Published on 2022-08-012022-09-11 Journal: International journal of toxicology [Category] 치료제, [키워드] 3CL administration Antiviral Arrhythmias assessment blood pressure cardiovascular caused clinical development Clinical pathology coagulation time Comprehensive conducted COVID-19 COVID-19 patient COVID-19 patients death decrease decreases development dose Drug safety Effect Efficacy Endpoint enhancer enzyme functional heart rate high risk highest dose Hospitalization Increases increases in induce Infection locomotor male MPro nervous system Nirmatrelvir not affect pathology Paxlovid pharmacokinetic Potential produced profile protease RATs Replication respiratory rate Ritonavir Safety safety pharmacology SARS-CoV-2 SARS-CoV-2 virus Support Supporting target tested the SARS-CoV-2 virus toxicities Toxicity toxicology transaminase transaminases Treatment treatment of COVID-19 were assessed [DOI] 10.1177/10915818221095489 PMC 바로가기 [Article Type] Article
The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patientsReview article Published on 2022-08-012022-10-05 Journal: Clinical Nutrition Open Science [Category] 임상, 치료제, [키워드] cause Clinical outcome coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical deficiency demonstrated dietary supplement Effectiveness Evidence immune system immunomodulatory effects infections information innate immune response management Micronutrient micronutrients mitigate overactive oxalate Patient patient population patients with COVID-19 pharmacological physiological physiological effect Prevent Randomized controlled trials reduce reduction in respiratory SARS-CoV-2 severe COVID-19 Therapeutic approach Toxicity viral infection Vitamin Vitamin C Zinc Zn [DOI] 10.1016/j.nutos.2022.06.006 [Article Type] Review article
Preliminary Genomic Analysis of the Omicron Variants of SARS-CoV-2 in Central India During the third wave of the COVID-19 PandemicResearch article Published on 2022-08-012022-10-05 Journal: Archives of medical research [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] Antiviral approach Beta bioinformatics clade COVID-19 Delta determine evolutionary relationship Gamma Health Illumina immune evasion India isolate Lineage machine Medicines Mutation Next-generation sequencing non-structural protein omicron Omicron variant other variants Phylogenetic Phylogenetic tree positive prevalent Result RNA SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variant SARS-CoV-2 variants SARS‐CoV‐2 sequence sequenced South Africa specimen spike Toxicity Transmissibility unique UPGMA Vaccine-induced immunity variant variants Variation virus VOCs [DOI] 10.1016/j.arcmed.2022.08.006 [Article Type] Research article