T cells – Page 73 – Communicable Diseases Research

COVID-19 Impairs Immune Response to Candida albicans

COVID-19는 Candida albicans에 대한 면역 반응을 손상시킵니다

Immunology

Published on 2021-02-262022-09-11
Journal: Frontiers in Immunology [Category] MERS, 바이오마커,

Title of article: Mucosal-associated invariant T cells in lung diseases

Review

Published on 2021-02-262022-11-01
Journal: International immunopharmacology [Category] COVID-19, SARS,

[키워드] 5-OE-RU, 5-(2-oxoethylideneamino)-5-dribitylaminouracil 5-OP-RU, 5-(2-oxopropylideneamino)-5-dribitylaminouracil 6-FP, 6 formylpterin activated adaptive AHR, airway hyper responsiveness APC, antigen presenting cell Asthma BALF, bronchoalveolar lavage fluid CAP, Community-acquired pneumonia CCR, CC receptor CD, cluster of differentiation Cell CF, cystic fibrosis chronic obstructive COPD, Chronic obstructive pulmonary disease COVID-19 COVID-19, Coronavirus disease 2019 CXCR, chemokine CXC receptor cytokine receptor Disease progression DN, double negative dynamic balance Effects Evidence FEV1, forced expiratory volume in the first second GM-CSF, granulocyte–macrophage colony-stimulating factor Gzm, granzyme HIF-1α, hypoxia-inducible factor-1α HLA-DR, human leukocyte antigen DR IFN-γ, interferon-γ IL, interleukin IL4I1, interleukin-4-induced gene 1 ILCs, innate lymphoid cells Immune cell immune response Immunity Immunopathogenesis Infection Inflammation Injury iNKT, invariant natural killer T involved lung lung cancer Lung disease Lung diseases Lungs maintain MAIT, Mucosal-associated invariant T marker MHC, major histocompatibility complex microbial infection MR1, MHC-related protein 1 Mucosa-associated invariant T cells murine Pathogenesis PD-1, programmed cell death protein 1 PLZF, promyelocytic leukemia zinc finger Pneumonia potential therapeutic target Protective pulmonary disease pulmonary inflammation pulmonary tuberculosis respiratory epithelium RORγt, retinoic-acid-related orphan receptor γt SARS-CoV-2 shown SLE, systemic lupus erythematosus STAT3, signal transducer and activator of transcription 3 subset T cell T cell receptor T cells TB, Tuberculosis TCF7, transcription factor 7 TCR, T cell receptor Th, T helper these cell title TLR, Toll-like receptor TNF-α, tumor necrosis factor-α Treatment
[DOI] 10.1016/j.intimp.2021.107485 PMC 바로가기 [Article Type] Review

Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients

Immunology

Published on 2021-02-242022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] Accessibility accompanied Activation Analysis approaches CD4 CD69 CD8 Cell Characteristics chromatin chromatin accessibility Control coronavirus diseases COVID-19 creating Critical element enhancer Epigenetic expressed function Genes HCs healthy HLA class II HLA-DRA HLA-DRB1 HLA-DRB5 immune Immune profile infected with COVID-19 inflammatory genes inflammatory pathways inflammatory state involved key factor landscape less MAPK moderate mononuclear cell motif Necrosis NFKBIA nine Pathogenesis Patient patients with COVID-19 PBMCs performed Peripheral blood PIK3R1 profile profiles promoter proportion Protein provided regions RNA S100A9 SARS-CoV-2 scATAC-seq scRNA-seq ScRNA-seq analysis seq Sequencing signaling pathway significantly Single Cell single-cell T cell T cells T-cell TBX21 Th1 TNF transcriptome profiling transcriptomic upregulated were used
[DOI] 10.3389/fimmu.2021.625881 PMC 바로가기 [Article Type] Immunology

Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

중증 COVID-19 환자의 폐에서 GM-CSF를 발현하는 조직 상주 기억 유사 T H 17 세포의 클론 확장 및 활성화

Research Article

Published on 2021-02-232022-09-12
Journal: Science Immunology [Category] Fulltext, MERS, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis Autoimmune diseases Bacterial bacterial pneumonia BAL Blood Bronchoalveolar lavage Bronchoalveolar lavage fluid CD8 Cell cell type cells cellular characterized Clinical course clonal expansion clone Cohort cohort of patient collected contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia CSF2 cytokine cytokine expression profile disease severity elevated expressing feature Generation GM-CSF helper high mortality hyperinflammation identify IL-17A IL17A Immune cell immune cell type immune cells immune response Immunopathogenesis interactome investigated involved lung lung damage Lung injury Lung pathology lung tissue Lungs Macrophage macrophages mechanism memory T cell moderate disease pathogenic Patient patients with COVID-19 Pneumonia protein level pulmonary T respiratory distress Respiratory distress syndrome serum severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia single-cell subsequent syndrome T cell T cell response T cells T helper TCR Th17 cells Therapies tissues Transcriptome Viral viral clearance viral infection
[DOI] 10.1126/sciimmunol.abf6692 PMC 바로가기 [Article Type] Research Article

Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19

Immunology

Published on 2021-02-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] accompanied acute respiratory syndrome age allele Analysis application AUC Cell characteristic class Cohort connection contributed coronavirus Course COVID-19 Critical death deaths Deceased died Elderly patient Genotype genotypes high risk HLA HLA class I HLA-A HLA-B HLA-C homozygote human leukocyte antigen immune response independent manuscript MHC class I Next-generation sequencing Patient patients with COVID-19 peptide peptide presentation presenting resulting risk ROC Russia SARS-CoV-2 severity significantly higher Spanish patient T cells the disease two group viral infection viral peptide Volunteer
[DOI] 10.3389/fimmu.2021.641900 PMC 바로가기 [Article Type] Immunology

The T cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role

Review

Published on 2021-02-232022-10-29
Journal: Oxford Open Immunology [Category] COVID-19,

Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients

중증 COVID-19 환자에서 자가포식 마커의 발현 감소 및 골수 유래 억제 세포의 확장은 불량한 T 세포 반응과 상관관계가 있습니다

Immunology

Published on 2021-02-222022-09-11
Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단,

[키워드] accumulation Activation Affect Analysis analyzed antibody production autophagy B cell B cells CD4+ T cell Cell cellular cellular and humoral immune response coronavirus coronavirus disease Coronavirus Disease (COVID)-19 correlated correlation COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Cytokines dendritic cell dendritic cells diagnostics disease dominant down-regulated driving dysregulated immune response ELISA expansion expression expressions flow-cytometry followed by functional healthy donor HLA-DR humoral immune response iCoS IFN-γ IL-10 IL-6 immune response immunological mechanism implication Inflammation interferon Laboratory parameters lymphocytopenia mild COVID-19 patient mild COVID-19 patients Monocytes multiorgan failure myeloid-derived suppressor cells NKT cells parameter PD-L1 Peripheral blood Pneumonia Poor quantitative PCR Regulatory regulatory lymphocytes respiratory response severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients significantly subset suppressor suppressor cells susceptible individuals T cell T cell response T cell subset T cells western blot
[DOI] 10.3389/fimmu.2021.614599 PMC 바로가기 [Article Type] Immunology

ApoB-Specific CD4 + T Cells in Mouse and Human Atherosclerosis

Review

Published on 2021-02-192024-09-02
Journal: Cells [Category] 대상포진,

[키워드] Apolipoprotein B Atherosclerosis Autoimmunity Immunity LDL T cells
[DOI] 10.3390/cells10020446 PMC 바로가기 [Article Type] Review

Inflammation and Antiviral Immune Response Associated With Severe Progression of COVID-19

COVID-19의 심각한 진행과 관련된 염증 및 항바이러스 면역 반응

Clinical Trial

Published on 2021-02-182022-08-13
Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 severity Disease progression disease severity downregulation Ex vivo Functional enrichment analysis H1N1 H1N1 virus healthy controls hemagglutinin host immune system hypercytokinemia IFNs immune cells immune response immune signature impair impaired function include indicate indicated Infection Inflammation Inflammatory Inflammatory response Influenza influenza A interferons LAG3 microarray analysis mild COVID-19 patient MMP9 mononuclear cell mononuclear cells myeloid cell myeloid cells Neutrophils novel respiratory disease overactivation overactive patients patients with influenza PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells potential mechanism potential mechanisms progression promote proportion Protein regulate Regulation respiratory Respiratory disease respond response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe and mild COVID-19 patients severe COVID-19 severe SARS severe SARS-CoV-2 severity Signaling SKAP1 spike Spike protein Stimulation suggested T cell T cells T cells TLR6 Transcriptome Type I IFN type I IFNs type I interferon type I interferons unique upregulation whole genome transcriptome with COVID-19
[DOI] 10.3389/fimmu.2021.631226 PMC 바로가기 [Article Type] Clinical Trial

Risk Factors for Mortality of COVID-19 Patient Based on Clinical Course: A Single Center Retrospective Case-Control Study

Immunology

Published on 2021-02-162022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] Analysis association B cell B cells case-control study CD4 T cells CD8 T cells center chronic disease CK-MB clinical Clinical characteristics Clinical course Clinical outcome Comorbidities complement component 3 complementary Complete correlation cough COVID-19 COVID-19 patient COVID-2019 CPR CRP cured cytokine D-dimer death Deceased Decreased discharged Dyspnea dysregulation electronic medical records evaluate evaluated Factor Factors ferritin Fever hypertension IL6 IL8 immune function immune response mechanisms immunological independent indicated Inflammatory Inflammatory biomarker inflammatory factors Inpatient Laboratory leucocytes logistic regression models lymphocyte Lymphocyte subset Lymphocyte subsets Mortality Most patient multivariable logistic regression myocardial enzymes Neutrophils NK cells outcome parameters Patient patients patients died positively correlated procalcitonin Prognosis Prognostic factor Prognostic value radiological retrospective risk factor ROC Curve SARS-CoV-2 SARS-COV-2 infection single center Spearman correlation analysis subset Symptom T cell T cells Tongji Hospital total bilirubin transferred variable was performed were used Wuhan
[DOI] 10.3389/fimmu.2021.581469 PMC 바로가기 [Article Type] Immunology