Characterization of γδT cells in lung of Plasmodium yoelii- infected C57BL/6 mice플라스모디움 요엘리 감염된 C57BL/6 마우스 폐에서의 γδT 세포 특성화Research Published on 2021-02-152024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] B cells lung Plasmodium T cells γδT cells [DOI] 10.1186/s12936-021-03619-z PMC 바로가기 [Article Type] Research
Restoration of type I interferon signaling in intrahepatically primed CD8 + T cells promotes functional differentiationResearch Article Published on 2021-02-082023-06-03 Journal: JCI Insight [Category] B형 간염, Fulltext, [키워드] Cellular immune response Hepatitis immunology Infectious disease T cells [DOI] 10.1172/jci.insight.145761 PMC 바로가기 [Article Type] Research Article
A lymph node–targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2림프절 표적 양친매성 백신은 SARS-CoV-2에 대한 강력한 세포 및 체액 면역을 유도합니다Research Article Published on 2021-02-052022-09-12 Journal: Science Advances [Category] MERS, 진단, [키워드] ACE2 receptor binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alum amphiphile Antibody Response Antibody responses Antigen antigen-specific T cell candidate vaccine cellular composed consequence convalescent patient coronavirus COVID-19 CpG cytokine Cytokines dose reduction Effective vaccines ENhance evaluated humoral immune response humoral immune responses Humoral immunity IgG3 immune responses immunization induce isotype isotypes lung parenchyma lymph Lymph node lymph nodes mice Modification neutralized preserved produced Protein Protein subunit vaccines Receptor binding Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus spike T cell T cells T helper the SARS-CoV-2 titers translation Vaccine [DOI] 10.1126/sciadv.abe5819 PMC 바로가기 [Article Type] Research Article
The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2ACE2에 의해 지원되는 COVID-19 감염에서 JAK-STAT 신호 전달 경로의 잠재적 관련성Article Published on 2021-02-052022-09-11 Journal: Gene [Category] 유전자 메커니즘, [키워드] ACE2 Activation angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B cells CD8 Cell coronavirus coronavirus disease correlation CoV infection COVID-19 COVID-19 infection downstream effective enzyme epithelial cells expected FOXP3 Gene Expression GSEA HAEs helper T cell helper T cells human airway epithelial human airway epithelial cells Immune cell immune response immunological indicated Infection investigated JAK-STAT signaling JAK-STAT signaling pathway macrophages mechanism nucleotide overactivation overexpressed pathway public health receptor regulate Regulatory reported respiratory SARS-CoV infection SARS-COV-2 infection Severe acute respiratory syndrome Signal-gene GSEA. similarity STAT T cell T cells Th1 cells Therapeutic strategies Treg [DOI] 10.1016/j.gene.2020.145325 PMC 바로가기 [Article Type] Article
Biologic Drugs for Rheumatoid Arthritis in the Context of Biosimilars, Genetics, Epigenetics and COVID-19 Treatment바이오시밀러, 유전학, 후성유전학 및 COVID-19 치료의 맥락에서 류마티스 관절염에 대한 생물학적 약물Review Published on 2021-02-042022-08-31 Journal: Cells [Category] 신약개발, [키워드] achievement addition Affect Arthritis B cell B cells bDMARDs biologic agent biologic agents Biological Biologicals biologics biosimilars Care Context COVID-19 COVID-19 outbreak diagnosing disability DNA methylation drug drugs drugs targeting effective effective therapy Efficacy epigenetics facilitate Factor genetics GM-CSF histone IL-1 IL-6 IMPROVE inhibit life limitation miRNA expression Modification patients Premature Quality of life respond Rheumatoid rheumatoid arthritis rheumatology Safe shown Symptom T cell T cells therapeutic intervention therapy TNF Treatment Usage widespread [DOI] 10.3390/cells10020323 PMC 바로가기 [Article Type] Review
Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients점막 관련 불변 T(MAIT) 세포는 COVID-19 환자에서 고도로 활성화되고 기능적으로 손상됩니다Article Published on 2021-02-032022-09-01 Journal: Viruses [Category] MERS, 진단, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Antiviral caused Cell cells contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 cytokine cytokine expression profile Cytokines cytolytic disease disease severity Ex vivo Express expression flow cytometry granzyme B HLA-DR IL-17A immune system Immunopathogenesis Impaired in vitro Infection lung marker measure Mild mucosal-associated invariant T (MAIT) cells Organ failure Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 perforin phenotype positively correlated progression Proinflammatory cytokine proinflammatory cytokines Proteins respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cells TNFα [DOI] 10.3390/v13020241 PMC 바로가기 [Article Type] Article
Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients중증 COVID-19 환자의 SARS-CoV-2에 대한 세포 면역 손상Immunology Published on 2021-02-022022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] acute infection acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adaptive immune response Adaptive immunity antibody Antibody Response ARDS CD4 CD8 cellular cellular immunity convalescent individual coronavirus COVID-19 COVID-19 patient develop exhibited expression healthy controls Hospitalization humoral immune responses IFNγ Impaired individual infection rate interferon gamma MOST mounted Neutralization antibody Neutralizing antibodies NK cell pandemic percentage Peripheral blood peripheral blood lymphocyte producing reduced responses SARS-CoV-2 severe COVID-19 patient Severe patient severe patients shown significantly Spread Symptoms syndrome T cell T cells Viral proteins virus [DOI] 10.3389/fimmu.2021.603563 PMC 바로가기 [Article Type] Immunology
Cell-Based Therapy for Severe COVID-19 Patients: Clinical Trials and Cost-Utility중증 COVID-19 환자를 위한 세포 기반 치료: 임상 시험 및 비용 활용Review Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] SARS, 임상, [키워드] Abstract acute respiratory distress acute respiratory distress syndrome antigen recognition approach approved Cell Cell therapy Cell-based therapy cellular clinical clinical study clinical trial clinical trials cost country COVID-19 decrease dendritic cells develop Exosome Exosomes Government immune response immune system Immunotherapy infected cells Inflammatory introduced mesenchymal stem cell Mesenchymal stem cells moderate moderate to severe MSC MSCs natural outcomes pandemic promote regulate respiratory distress resulting stem cell stimulate syndrome T cell T cells Therapeutics therapy treating COVID-19 treating COVID-19 patient Treatment Trial Vaccine Viral viral disease Viral diseases viral infections virus-infected cell virus-infected cells [DOI] 10.1007/s12015-020-10046-1 PMC 바로가기 [Article Type] Review
Immune responses and pathogenesis in persistently PCR-positive patients with SARS-CoV-2 infection지속적으로 PCR 양성인 SARS-CoV-2 감염 환자의 면역 반응 및 발병기전Case Reports Published on 2021-02-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Beijing Capital caused CD27 CD3 CD38 CD4 CD8 Chain Reaction China clinical condition collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients declined DPT function functions HLA-DR Imbalance immune Immune cell immune cells immune response Inpatient key factor killer cells Laboratory nucleic acid nucleic acid conversion. occurred outcome outcomes Pathogenesis Patient patients patients with COVID-19 PCR-negative PCR-positive PCR-positive patient Peripheral blood Peripheral blood sample peripheral blood samples phenotype polymerase chain polymerase chain reaction Population proportion proportions respiratory response SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity Spread T cell T cells T killer cell T killer cells two group two groups university [DOI] 10.1002/jmv.26287 PMC 바로가기 [Article Type] Case Reports
The fragility of humoral immunity as a physiological safety marker for healthcare workers to return after COVID-19 convalescenceCOVID-19 회복 후 의료 종사자가 복귀하기 위한 생리학적 안전 지표로서의 체액성 면역의 취약성Case Reports Published on 2021-02-012022-09-12 Journal: Journal of microbiology, immunology, and infection [Category] MERS, 진단, [키워드] Abstract COVID-19 healthcare worker Humoral immunity immune response marker physiological SARS-CoV-2 T cells [DOI] 10.1016/j.jmii.2020.08.012 PMC 바로가기 [Article Type] Case Reports