Self-injectable extended release formulation of Remdesivir (SelfExRem): A potential formulation alternative for COVID-19 treatment렘데시비르(SelfExRem)의 자가 주사 가능한 연장 방출 제형: COVID-19 치료를 위한 잠재적 제형 대안Article Published on 2021-03-152022-08-31 Journal: International journal of pharmaceutics [Category] MERS, SARS, 신약개발, 진단, 치료법, 치료제, [키워드] administer analyzed approach approval autoinjector benefit biodegradable polymer Care carried Concentration coronavirus Coronavirus 2019 COVID-19 COVID-19 patients COVID19 drug Drug administration effective evaluated face-to-face contact FDA food force Frequency globe Health Health care help Hospitalization In situ depot formulations indicated injection Intravenous injection Intravenous remdesivir Long-acting injectables low molecular weight mass vaccination pandemic Patient phosphate phosphate buffer PLGA Polymer provided RDV receiving reducing Remdesivir required Research SARS-CoV2 subcutaneous injection therapeutic Treatment treatment of COVID-19 tween vaccination w/v [DOI] 10.1016/j.ijpharm.2021.120329 PMC 바로가기 [Article Type] Article
Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasmaCOVID-19 회복기 혈장에서 IgG로 SARS-CoV-2 중화Article Published on 2021-03-102022-09-01 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] administer antibody approach change clinical utility COVID-19 patient COVID-19 patients detectable Dilution elicit endpoints examined fraction greater IgG immune response Immunotherapy inhibited neutralization activity Neutralizing activity plasma plasma sample plasmas producing quantification reduced required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patients surrogate the patient viral infection while [DOI] 10.1038/s41598-021-84733-5 PMC 바로가기 [Article Type] Article
The BCG Vaccine for COVID-19: First Verdict and Future DirectionsImmunology Published on 2021-03-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome administer Administered bacille Calmette-Guérin BCG BCG vaccination bcg vaccine Care catastrophic characterized clinical trials coronavirus cost-effective intervention country cross-protection cross-protective decrease direction Diseases dose Effect effort Epigenetic explained Future Health health system highlighting immune responses Immunity inflammatory cytokine production innate immune memory Macrophage mitigate offer overcome pandemic Prophylactic proportion reported respiratory infections respiratory infectious disease SARS-CoV-2 SARS-COV-2 infection Sickness the vaccine this new coronavirus trained immunity Treatment Tuberculosis vaccinate vaccination Vaccine vaccine for COVID-19 [DOI] 10.3389/fimmu.2021.632478 PMC 바로가기 [Article Type] Immunology
Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologiesResearch article Published on 2021-03-012022-10-05 Journal: Medicine in Drug Discovery [Category] 비임상, [키워드] administer administration approach binding changes in disease drug delivery exogenously Extended release oral overcome Parenteral Patient-centricity peptide peptides physicochemical property problem targets therapeutic agent Treatment trend [DOI] 10.1016/j.medidd.2020.100079 [Article Type] Research article
Insights into the actions of angiotensin-1 receptor (AT1R) inverse agonists: Perspectives and implications in COVID-19 treatmentReview Article Published on 2021-02-082022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] “cytokine storm” administer agonist angiotensin receptor blocker Angiotensin-converting enzyme ARB ARBs AT1R candesartan candidate caused clinical manifestation complex Complication Compound coronavirus SARS-CoV-2 Course COVID-19 COVID-19 disease deaths drug drugs Effect effective Effectiveness Evolution health care systems Hypothesis identify implication Infection insight management molecular New oxidative stress pathophysiology Patient patients with COVID-19 receptor reduce reducing renin-angiotensin-aldosterone system risk factor Risk factors SARS-CoV-2 severity specific treatment suggested therapy Treatment [DOI] 10.17179/excli2021-3412 PMC 바로가기 [Article Type] Review Article
Small animal jet injection technique results in enhanced immunogenicity of hantavirus DNA vaccinesResearch article Published on 2021-02-012022-10-05 Journal: Vaccine [Category] 비임상, [키워드] administer Administered Ande antigen expression disease DNA vaccine Efficacy epidermal evaluated fibroblast cells gene gun hamster hamsters hantavirus immunogenic immunogenicity Increased immunogenicity injection intramuscular Jet injection lethal disease medical countermeasure Medicine mRNA stability nucleic acid optimization overcome Protective RNA shown tested the vaccine tissues Tropis vaccination Vaccine virus Volume was used [DOI] 10.1016/j.vaccine.2021.01.002 [Article Type] Research article
User-testing guidelines to improve the safety of intravenous medicines administration: a randomised in situ simulation studyOriginal Research Published on 2021-01-302022-10-28 Journal: BMJ Quality & Safety [Category] COVID-19, MERS, SARS, [키워드] 95% CI administer Administered Care clinical guideline clinical practice guidelines Direct Frequency greater guide Health identify IMPROVE increase information intravenous investigated less medication medication safety Medicine Medicines moderate-severe Modification National Health Service Nurses objective observation occurred parallel group participant patient safety Primary outcome randomised reduce reported Result risk severity statistically significant subsequent was measured was used [DOI] 10.1136/bmjqs-2020-010884 PMC 바로가기 [Article Type] Original Research
Treating COVID-19: are we missing out the window of opportunity?COVID-19 치료: 기회의 창을 놓치고 있습니까?Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] Coronavirus, 치료제, [키워드] administer Antiviral approach benefit cascade Course COVID-19 disease Efficacy events followed by Immunomodulatory agent Immunomodulatory agents immunomodulatory therapy Inflammatory inflammatory cascade initial offer severe COVID-19 severe disease the disease time interval time intervals translated treating Treatment Viral viral replication [DOI] 10.1093/jac/dkaa442 PMC 바로가기 [Article Type] Article
Impact of a pandemic on surgical neuro-oncology—maintaining functionality in the early phase of crisisResearch Article Published on 2021-01-182022-10-28 Journal: BMC Surgery [Category] COVID-19, MERS, [키워드] activity administer Asian change Chinese Coronavirus disease 2019 country COVID-19 COVID-19 negative COVID-19 pandemic early phase Elective surgery feature global healthcare highlight hospital Impact impacted initiated measure median Modification MOST Neuro-oncological surgery Neuro-oncology neurosurgery pandemic Patient patient triage performed questionnaire raise recommendation reduced reduction in reported Research response Result Society Stage surgical therapy Volume WHO widespread [DOI] 10.1186/s12893-021-01055-z PMC 바로가기 [Article Type] Research Article
Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating StudyArticle Published on 2021-01-142022-10-31 Journal: Nutrients [Category] COVID-19, [키워드] administer Administered amplified Analysis benefit cholecalciferol cholecalciferol treatment clinical Clinical characteristics Clinical outcome clinical trial comorbid disease comorbid diseases comorbid patient Comorbidity COVID-19 COVID-19 patients D-dimer level death diagnosis of SARS-CoV-2 died Effect elevated Endpoint explain follow-up period High-dose Hospitalized ICU In-hospital information intensive care Logistic regression analysis Mortality offer oral cholecalciferol outcome over Patient positive predictive power Propensity score receiver operating characteristic receiving Retrospective study significantly smoking transfer transferred treated Treatment Vitamin D vitamin D levels was recorded with COVID-19 [DOI] 10.3390/nu13010219 PMC 바로가기 [Article Type] Article