Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon OmegaCase Report Published on 2020-10-272022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] adenosine adenosine nucleoside analogue Administered AGP alpha-1 acid glycoprotein analogue coronavirus diagnosed eye drop Feline infectious peritonitis feline interferon omega forest glycoprotein interferon kidney lesion limits low-dose Lymph node male mesenteric lymph node Mutian nucleoside Omega oral peritonitis polymerase chain precipitates prednisolone acetate Rapid reduced reducing Resolution resolved RNA symmetric dimethylarginine Treatment Uveitis weight loss [DOI] 10.3390/v12111216 PMC 바로가기 [Article Type] Case Report
An Assessment of the Novel COVISTRESS Questionnaire: COVID-19 Impact on Physical Activity, Sedentary Action and Psychological EmotionArticle Published on 2020-10-192022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Action activity analogue Analysis Anxiety applied approval assessment caused Community conducted consequence coronavirus correlation country COVID-19 COVID-19 outbreak COVID-19 pandemic Depression Descriptive statistics distress emotion emotional evaluated female Health Impact intensity Isolation male measure Measures moderate no correlation novel outbreak participant performed physical physical activity Psychological psychological Impact question questionnaire reduced reported response resulting scale sedentary time selected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significance level significant difference Sociodemographic Spearman Stress stress level stressors triggered Visual Wilcoxon signed-rank test [DOI] 10.3390/jcm9103352 PMC 바로가기 [Article Type] Article
The Application of Porphyrins and Their Analogues for Inactivation of VirusesReview Published on 2020-09-232022-10-30 Journal: Molecules [Category] Coronavirus, SARS, [키워드] analogue antiviral activity application approach Chlorin combating Compound conjugate DNA Effectiveness identify inactivation information photochemical phthalocyanines Porphyrin porphyrins SARS-CoV target Treatment viral disease viral infection viral infections virus viruses [DOI] 10.3390/molecules25194368 PMC 바로가기 [Article Type] Review
Circulating levels of soluble Dipeptidylpeptidase-4 are reduced in human subjects hospitalized for severe COVID-19 infectionsComment Published on 2020-09-212022-10-30 Journal: International journal of obesity (2005) [Category] COVID-19, SARS, [키워드] ACE ACE2 addition analogue Analysis binding CD26 cell types circulating Clinical management Concentration Control Course COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 patient decrease Enzymes eukaryotic examined healthy Hospitalized hospitalized patient Host immune cells infections inhibitor membrane metabolic disease not different obesity Patient protease reduced Regulatory risk factor Risk factors Sepsis serum Severe COVID-19 Infection shown significantly lower subject subjects the disease type 2 diabete type 2 diabetes virus viruses [DOI] 10.1038/s41366-020-00689-y PMC 바로가기 [Article Type] Comment
Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19Short Communication Published on 2020-08-292022-11-01 Journal: Virus research [Category] COVID-19, MERS, SARS, [키워드] 3CLpro Abstract ACE2 ADME analogue approach approved Arbidol binding affinity clinical trial Compound COVID-19 demonstrated docking docking score enzyme Epidemic exhibited furin health emergency host protease in-silico Influenza virus inhibitor Interaction interactions Invasion involved limit membrane fusion molecular molecular docking novel Novel coronavirus other protease other proteases predicted protease receptor replication of SARS-CoV-2 reported residue SARS-coronavirus SARS-CoV-2 SARS-CoV-2 SP Scaffold morphing serine 2 Spread targets the SARS-CoV-2 therapeutic therapy TMPRSS2 transmembrane umifenovir Virtual screening virus Wuhan, China [DOI] 10.1016/j.virusres.2020.198146 PMC 바로가기 [Article Type] Short Communication
Immunosuppressive Drugs and COVID-19: A ReviewPharmacology Published on 2020-08-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” acute respiratory syndrome analogue ARDS calcineurin inhibitors case-control study caused clinical clinical trial cohort study concerning control group coronavirus Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 detrimental drug Effect Evidence Host immune response Human IL-6 inhibitors immunosuppressive drug immunosuppressive drugs In-vitro indication infection with SARS-CoV-2 inhibit inhibitory effect initial mechanical ventilation MERS-CoV Middle East Mortality mTOR inhibitor mTOR inhibitors multiorgan failure mycophenolic acid observational study overshoot pandemic patients with COVID-19 positive result Prevent Randomized controlled trial RCTs reduce mortality Registered respiratory syndrome coronavirus Result review risk of bia SARS-CoV SARS-CoV-2 SARS-CoV-2 replication standard care Study protocol Tocilizumab viral replication [DOI] 10.3389/fphar.2020.01333 PMC 바로가기 [Article Type] Pharmacology
Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and VancomycinFull Paper Published on 2020-07-302022-10-31 Journal: ChemMedChem [Category] Coronavirus, [키워드] active against analogue Antibiotics Antiviral antiviral activity antiviral agent antiviral drug Bacteria block concentrations coronavirus cytotoxicity derivative evaluated glycopeptide antibiotic Health herpes simplex hydrophobic inactive Influenza virus influenza viruses inhibitor linker nontoxic perfluoroalkyl plan selective synthesis Teicoplanin vancomycin virus viruses [DOI] 10.1002/cmdc.202000260 PMC 바로가기 [Article Type] Full Paper
A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 age analogue anticipated assigned Asymptomatic blinded bpm Characteristics clinical trial comparator components Contact Controlled trial coronavirus disease COVID-19 COVID-19 symptom COVID19 Date deficiency develop Diabetes Mellitus Diagnosis disease dissemination dose double-blind drug Efficacy Efficiency eight element enrolled enrolment EU Clinical Trial evaluate evaluate the effect exclusion criteria experimental arm female participant Final Glucose haloperidol healthcare healthcare worker Healthcare workers hematological Hemodialysis hepatitis B Hereditary high risk history HIV HIV infection hospital hypersensitivity IgM/IgG immune immunosuppressive incidence Inclusion Infection Inflammatory cytokine Intervention less lymphopenia male melatonin men and women multicenter myasthenia gravis number objective outcome participant Patient PCR Placebo polymerase chain post-symptom onset Premenopausal Prevent prophylactic treatment Prophylaxis protocol Ramón randomisation randomised randomised controlled trial randomization Randomized Rapid test receiving recruited renal failure Research Retinitis rheumatoid arthritis risk RT-PCR Sample size SARS-CoV 2 SARS-CoV-2 SARS-COV-2 infection SAS version 9.4 secondary sequence Seroconversion severe COVID-19 severity of COVID-19 Sex Spain Spanish statistical status stratified study drug Study protocol symptomatic infection symptomatic SARS-CoV-2 infection Treatment Trial two-arm parallel ulcerative colitis understanding urinary pregnancy test Vasculitis website weight women [DOI] 10.1186/s13063-020-04436-6 PMC 바로가기 [Article Type] Letter
Synthetic surfactin analogues have improved anti-PEDV propertiesResearch Article Published on 2019-04-112022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities analogue antiviral activity antiviral drug Antiviral effect Concentration concentrations Critical cytotoxicity derivative determine develop effective evaluated greater groups inhibiting Like linear PEDV Safe surfactin synthetic utility viral membrane virus [DOI] 10.1371/journal.pone.0215227 PMC 바로가기 [Article Type] Research Article
The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffoldReview Article Published on 2018-04-102024-09-04 Journal: Antiviral Research [Category] 대상포진, [키워드] analogue anticancer Antiviral history Modification nucleoside [DOI] 10.1016/j.antiviral.2018.04.004 PMC 바로가기 [Article Type] Review Article