Tetravalent Influenza Vaccine Is Not Associated With Neuroaxonal Damage in Multiple Sclerosis PatientsImmunology Published on 2021-08-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] addition Administered antibody production Antibody Response Antigen baseline both group changes in Cohort comparable controls COVID-19 criteria damage disease Disease activity fumarate HCs healthy control humoral immune response immunization increase in Influenza influenza vaccines investigated limit Multiple multiple sclerosis NfL objective Patient patients treated primary endpoint proportion Prospective Study radiological receiving Result sclerosis Seasonal influenza Seroconversion serum Strains tetravalent titers treated vaccination Vaccine [DOI] 10.3389/fimmu.2021.718895 PMC 바로가기 [Article Type] Immunology
B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshapingB 세포 수용체(BCR) 유도 기계 변환: SARS-CoV-2 특이적 B 세포가 근위 신호 전달 및 항체 재형성을 촉발하도록 지시하는 중요한 가설Article Published on 2021-08-012022-09-12 Journal: Medical Hypotheses [Category] MERS, SARS, 진단, [키워드] activate Activation acute respiratory syndrome antibody antibody production antigens APCS approval B cell B cell receptor BCR BCR dynamics BCR spatiotemporal dynamics binding cause consequence coronavirus COVID-19 develop event globe Health Hypothesis immune immune mechanism Immunity In-vitro Infection Interaction Mechanotransduction motif mRNA vaccine neutralizing antibody Pathogens Phosphorylation Prevent proximal receptor Region respond SARS-CoV-2 SARS-CoV-2 infected patient Signal transduction spatiotemporal Spread Structure targeting therapeutic translate triggered tyrosine undergo Vaccine entanglements. virus receptor [DOI] 10.1016/j.mehy.2021.110640 PMC 바로가기 [Article Type] Article
Serologic Status and Toxic Effects of the SARS-CoV-2 BNT162b2 Vaccine in Patients Undergoing Treatment for CancerResearch Published on 2021-07-082022-10-30 Journal: JAMA Oncology [Category] COVID-19, [키워드] 95% CI Administered administration adverse effect adverse event Adverse reaction age antibody production anticancer appear blood cell counts BNT162b2 BNT162b2 vaccine Campus Cancer Chemotherapy Cohort cohort study collected conducted Control controls COVID-19 case COVID-19 infection determine division Effect Efficacy Efficacy and safety electronic medical record enrolled evaluate evaluated exposure finding first dose Future Health care worker healthy healthy individuals high-risk population IgG Importance incidence initiated leukopenia liver enzyme measure men objective occur occurred Odds ratio of BNT162b2 participant Patient patients Patients with cancer Phase 3 Point populations rate ratio reached real-world data receiving reduced Regulatory Relevance reported Result Safe SARS-CoV-2 BNT162b2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose Seroconversion serologic seronegative patients Seronegativity seropositive serum serum sample setting Sociodemographic characteristics status Testing the healthy the patient the SARS-CoV-2 the vaccine therapy toxic Treatment Trial trials vaccination Vaccine vaccine dose was used [DOI] 10.1001/jamaoncol.2021.2675 PMC 바로가기 [Article Type] Research
Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 InfectionArticle Published on 2021-07-052022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adverse effects antibody production applied BNT162b2 comparable Complete complications COVID-19 doses Effect Efficacy evaluated expected healthcare worker immunization in both group individual Neutralizing antibodies neutralizing antibody neutralizing capacity Pfizer-BioNTech Prevent response SARS-CoV-2 SARS-COV-2 infection second dose side Side effect single dose Support titer USA vaccination Vaccine vaccine side effects virus worker [DOI] 10.3390/vaccines9070742 PMC 바로가기 [Article Type] Article
High Prevalence of Anti-PF4 Antibodies Following ChAdOx1 nCov-19 (AZD1222) Vaccination Even in the Absence of Thrombotic EventsArticle Published on 2021-07-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activating anti-PF4 antibodies antibody antibody production Antibody Response AZD1222 baseline ChAdOx1 ChAdOx1 nCoV-19 Clinical characteristics Clinical data clinically COVID-19 elicit evaluate first dose IgG antibody induce multifactorial no correlation offer pathophysiology patients presence of antibody Prospective Study provoke recipient SARS-CoV-2 the vaccine thrombosis thrombotic event vaccinated individual Vaccine [DOI] 10.3390/vaccines9070712 PMC 바로가기 [Article Type] Article
AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19AID와 APOBEC를 다면적 고유 바이러스 제한 요인으로: COVID-19에 비추어 볼 때 새로운 개념Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] AID AID/APOBECs gene expression signature anatomical antibody production Antiviral antiviral response APOBEC APOBEC4 APOBECs Apolipoprotein B catalytic cell type cell types concept Coronaviruses COVID-19 cytidine Cytidine deaminase cytosine determinant Dissection DNA and RNA driving enzyme expression family members focus gene signature Germinal center highlight Host humoral immune response intrinsic LIGHT lymphoid lymphoid structures master regulator mechanism memory B cells mRNA plasma plethora polymorphism Reactions SARS-CoV-2 Structure subunit the patient uracil variety virus viruses [DOI] 10.3389/fimmu.2021.690416 PMC 바로가기 [Article Type] Immunology
COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operativelyCOVID-19(SARS-CoV-2) 림프구 반응은 수술 전 총 관절 교체 수술 후보의 염증성 바이오마커와 관련이 있습니다Research Article Published on 2021-06-302022-09-10 Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, SARS, 바이오마커, 치료법, [키워드] addition analyzed antibodies antibody antibody production Blood candidate Cohort coronavirus COVID-19 cross-reactivity elective surgeries Elective surgery exhibited exposure to General population IgG antibodies IgG antibody IL-1ra IL-1β IL-6 Immunity Inflammatory biomarker inflammatory biomarkers joint LTT lymphocyte lymphocyte response lymphocyte responses Lymphocytes median age memory nucleocapsid nucleocapsid protein Nucleocapsid proteins parameter Patient peripheral Peripheral blood positive pre-vaccination pro-inflammatory biomarkers profiles protective immunity Protein reactive reactivity recent Registered response Result Retrospective study risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 virus serum spike and nucleocapsid proteins Spike protein Spike proteins T cell T cell memory the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein TNFα Total Total joint arthroplasty Trial registration vaccination vaccination Methods [DOI] 10.1186/s13018-021-02563-7 PMC 바로가기 [Article Type] Research Article
Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New VariantsMedical Technology Published on 2021-06-302022-11-01 Journal: Frontiers in Medical Technology [Category] COVID-19, [키워드] ACE2 alteration Analysis Angiotensin-converting enzyme antibody production B-cell B.1.351 binding affinity carried cellular receptor Combination conformational state conformational states contribute coronavirus COVID-19 pandemic disease dose Efficiency electrostatic interactions epitope Epitopes explain Hospitalization Increased Infection Interaction mapped molecular mechanism Mutation mutations New protein–protein interactions raising RBD RBD-ACE2 released responsible S trimer SARS-CoV-2 South spike Spread stability state Structure the receptor-binding domain the SARS-CoV-2 the vaccine Therapeutic molecule therapeutic option Transmissibility trimeric variant variants variants of SARS-CoV-2 virulence virulent virus wild type [DOI] 10.3389/fmedt.2021.694347 PMC 바로가기 [Article Type] Medical Technology
Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapyResearch Article Published on 2021-06-282022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] antibody antibody production Autoimmune disease B cells benefit blockade Cancer immunotherapy cancers CD4 CD44 CD8 Combination COVID-19 patient decrease Deleterious dose effectors examined expression HCQ Hydroxychloroquine Immune checkpoint blockade Immunotherapy increase in indicate infiltrating inhibited mice myeloid cells no effect patients PD-L1 promote Regulatory T cell rejection rheumatoid arthritis subset systemic lupus erythematosus T cell T cells Therapeutic benefit thymic treat Treatment Tregs tumor cells tumors vasculature [DOI] 10.1371/journal.pone.0251731 PMC 바로가기 [Article Type] Research Article
Serological response to SARS-CoV-2 vaccination in multiple sclerosis patients treated with fingolimod or ocrelizumab: an initial real-life experience핀골리모드 또는 오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 백신 접종에 대한 혈청학적 반응: 초기 실생활 경험Original Communication Published on 2021-06-262022-09-12 Journal: Journal of Neurology [Category] MERS, 진단, [키워드] anti-SARS-CoV-2 antibody production Clinical data clinical feature Clinical features clinical history collected data Complete Course COVID-19 Data collection dose fingolimod humoral Humoral response initial Italy lack multiple sclerosis objective observation Ocrelizumab Patient patients patients treated positive present receiving recent Result San Raffaele Hospital SARS-COV-2 infection SARS-CoV-2 vaccination Serological assay serological response serological test treated Treatment vaccination Vaccine White blood cell White blood cells [DOI] 10.1007/s00415-021-10663-x PMC 바로가기 [Article Type] Original Communication