Haemodialysis patients show a highly diminished antibody response after COVID-19 mRNA vaccination compared with healthy controls혈액 투석 환자는 건강한 대조군에 비해 COVID-19 mRNA 백신 접종 후 항체 반응이 크게 감소했습니다Article Published on 2021-08-272022-09-12 Journal: Nephrology, dialysis, transplantation : official p [Category] MERS, 진단, [키워드] acute respiratory syndrome adverse event AEs Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 S antibodies Antibody Response Antibody titre Cohort conducted control group control patient controls coronavirus correlation COVID-19 mRNA Vaccination Critical dialysis doses Efficacy expected group Haemodialysis patient HD group healthy control healthy controls Hepatitis B vaccination high mortality rate high risk Infection less median mRNA vaccination mRNA vaccine pandemic participant Patient prospective cohort study questionnaire Regression responses against SARS-CoV-2 SARS-CoV-2 S second dose significantly lower the antibody response the SARS-CoV-2 translate Trial vaccination Vaccine Vaccines was measured were assessed [DOI] 10.1093/ndt/gfab179 PMC 바로가기 [Article Type] Article
Robust Antibody Responses to the BNT162b2 mRNA Vaccine Occur Within a Week After the First Dose in Previously Infected Individuals and After the Second Dose in Uninfected IndividualsBNT162b2 mRNA 백신에 대한 강력한 항체 반응은 이전에 감염된 개인의 경우 첫 번째 접종 후 일주일 이내에, 감염되지 않은 개인의 경우 두 번째 접종 후 발생Immunology Published on 2021-08-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike anti-spike and anti-nucleocapsid antibodies antibody Antibody Response Antibody responses Antibody titre antibody titres Blood blood sample Blood samples BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine collected conducted coronavirus coronavirus disease COVID-19 exposure to first dose FIVE genders HCW HCWs Health care Health care worker immunisation Immunity increase in Incubation period individual infected individuals Kinetics mRNA vaccine occurred offer pandemic path Patient respiratory response restrict viral replication Result robust SARS-CoV-2 second second dose second vaccination serological analysis severe acute respiratory syndrome Coronavirus Severity of disease Spike protein the spike protein titre Trigger vaccinated individual vaccinated individuals vaccination Viral viral replication virus was performed Week [DOI] 10.3389/fimmu.2021.722766 PMC 바로가기 [Article Type] Immunology
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice다량체화된 SARS-CoV-2 수용체 결합 도메인(RBD)을 사용한 단일 용량 면역은 마우스에서 강화된 보호 반응을 유도합니다Research Letter Published on 2021-08-222022-09-12 Journal: Febs Letters [Category] MERS, 진단, [키워드] Analysis Antibody titre Antigen antigens Bacteria buffer caused complexes coronavirus COVID‐19 COVID‐19 defined demonstrated Dps elicited exclusion experiment expressed form health emergency highlight immunisation increase induce introduced lung mammalian cells mice Microscopy monomeric RBD neutralising antibody pandemic Particle PBS preparation Protective purified Quality control RBD Receptor binding domain SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 SDS spike Subunit vaccine triggered Vaccine viral clearance were expressed [DOI] 10.1002/1873-3468.14171 PMC 바로가기 [Article Type] Research Letter
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older peopleResearch Published on 2021-08-202022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] adenovirus vaccine adenovirus-based Analysis antibody Antibody Response Antibody titre blood sample BNT162b2 BNT162b2 mRNA boost cellular Cellular immune response cellular response ChAdOx1 ChAdOx1 vaccine Clinical efficacy clinical risk COVID detectable Donor electrochemiluminescence immunoassay elicited Evidence extended interval extended-interval heterologous vaccine homologous Homologous vaccine Humoral immunity IFN-γ ELISPOT immune response immune senescence induce Infection IQR limit median Meta-analysis mRNA natural infection objective of BNT162b2 offer Older participant Patient platform protocol question recipient regimen regimens reported response Result SARS-CoV-2 SARS-CoV-2 vaccine second dose shown Spike protein Spike-specific antibody stability supplementary material T cell response the median vaccination Vaccine vaccine responses vaccinee were assessed were measured [DOI] 10.1186/s12979-021-00246-9 PMC 바로가기 [Article Type] Research
Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibodyMW33의 안전성, 내약성, 약동학 적 특성 및 면역 원성 : SARS-COV-2 RBD- 표적 모노클로 날 항체의 1 상 임상 연구Clinical Trial Published on 2021-08-182022-08-13 Journal: Emerging Microbes & Infections [Category] SARS, 임상, 진단, 치료제, [키워드] adverse event adverse events AEs Antibody titre antibody titres AUC C max clinical study Concentration concentration-time curve conducted coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated Diseases disorders dose dose-escalation double-blind enrolled evaluate Evidence evidence of follow-up period fully humanized IgG1κ monoclonal neutralizing antibody GRADE Grade 1 group healthy subjects humanized Identifier immunogenicity incidence Infectious diseases infused Laboratory Laboratory test linear kinetic relationship linear PK maximum concentration monoclonal monoclonal antibody MW33 MW33 injection NCT04427501 neutralizing antibody no evidence of participant pharmacokinetic characteristics pharmacokinetics Phase 1 Phase 1 clinical trial phase 1 study PK parameters Placebo placebo-controlled plasma half-life positive rate positive rates Randomized Safety SARS-CoV-2 serum ADA serum ADAs severity subject the SARS-CoV-2 Tolerability Treatment Trial registration Vascular vascular and lymphatic disorders [DOI] 10.1080/22221751.2021.1960900 PMC 바로가기 [Article Type] Clinical Trial
Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19계절 인간 코로나바이러스 OC43에 대한 면역은 COVID-19의 치명적인 악화를 완화합니다Article Published on 2021-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analysed antibody Antibody titre antibody titres cleavage cleavage site Clinical course Clinical data conserved coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 cross-reactive antibodies cross-reactive antibody cross-reactivity detect Deterioration develop disease Effect enzyme enzyme-linked immunosorbent assay epitope Epitopes fusion fusion peptide help human coronavirus human coronavirus OC43 Immunity immunogenic Immunosuppression Inpatient Inpatients investigated Mild mitigate not differ OC43 Outpatient outpatients patients with COVID-19 peptide peptides Pneumonia predict produced Prognosis respiratory S2ʹ cleavage site SARS-CoV-2 searched sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe cases Standard therapy titre with COVID-19 [DOI] 10.1016/j.ijid.2021.07.015 PMC 바로가기 [Article Type] Article
Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia만성 림프구 백혈병 환자에서 제 1 및 제 2 코비드 -19 백신 접종 후 항체 반응Clinical Trial Published on 2021-07-302022-08-09 Journal: Blood Cancer Journal [Category] 임상, 진단, [키워드] Adaptive immunity Antibody Response Antibody responses Antibody titre antibody titres B-cell blood sample Blood samples BNT162b2 BNT162b2 mRNA vaccine booster vaccines BTK inhibitor BTK inhibitors ChAdOx1 Chronic lymphocytic leukaemia clinical risk CLL COVID-19 vaccines detectable dried blood spot Dried blood spots extended interval failure Filter Paper generate healthy donor healthy donors IgA deficiency Immunosuppression Multivariate analysis offer Patient profile remained SARS-COV-2 infection second vaccination Severe infection spike-specific antibody response Spike-specific antibody responses Support the antibody response the patient titre titres Translational research Treatment utility vaccination Vaccination strategy Vaccine venepuncture [DOI] 10.1038/s41408-021-00528-x PMC 바로가기 [Article Type] Clinical Trial
Waning antibody responses in COVID-19: what can we learn from the analysis of other coronaviruses?Review Published on 2021-07-292022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome Affect affecting Analysis antibodies antibody Antibody Response Antibody titre antibody waning booster dose caused consequence coronavirus disease Course COVID-19 Critical cross-reactivity develop Effect endemic human coronaviruses evaluate Factor Follow-up HCoV Immunity implication inaccuracy incidence Infection initial memory B MERS Middle East Mortality novel Betacoronavirus objective other coronavirus pandemic predict Protective public health required respiratory syndrome coronavirus SARS SARS-CoV SARS-CoV-2 serological Serological testing T-cell vaccination vaccine-induced antibody vaccine-mediated immunity viral strain [DOI] 10.1007/s15010-021-01664-z PMC 바로가기 [Article Type] Review
A persistent epidemic of porcine epidemic diarrhoea virus infection by serological survey of commercial pig farms in northern VietnamResearch Article Published on 2021-07-052022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] age Antibody titre carried collected contagious diarrhoea ELISA Endemic Epidemic Evidence expressed Impact indicate Infection Infectious disease management Northern Vietnam OD value outbreak PED PEDV Pig farm Porcine epidemic diarrhoea virus Randomly reported Result sera serological evidence serological survey significant difference significantly higher virus infection widespread [DOI] 10.1186/s12917-021-02941-7 PMC 바로가기 [Article Type] Research Article
Seroprevalence of SARS-CoV-2 antibodies in children: a prospective multicentre cohort study소아에서 SARS-CoV-2 항체의 혈청 유병률: 전향적 다기관 코호트 연구Observational Study Published on 2021-07-012022-09-12 Journal: Archives of Disease in Childhood [Category] SARS, 임상, 진단, [키워드] 95% CI age Analysis Antibody titre blood sample changes in children cohort study conducted Contact demonstrated enrolled Epidemiology fatigue Final Gastrointestinal symptom healthcare independent variable Infection median age molecular multicentre multivariable analysis no symptom Observational cohort study participant positive presence of antibody provided recruited reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody test SARS-CoV-2 antibody testing SARS-COV-2 infection Selection bias sense of smell sensitivity Seroprevalence significantly Swab Symptom Symptoms the mean Virology [DOI] 10.1136/archdischild-2020-320558 PMC 바로가기 [Article Type] Observational Study