Microneedle-based two-step transdermal delivery of Langerhans cell-targeting immunoliposomes induces a Th1-biased immune responseLangerhans 세포 표적 면역리포좀의 미세바늘 기반 2단계 경피 전달은 Th1 편향 면역 반응을 유도합니다Article Published on 2022-08-012022-09-12 Journal: European journal of pharmaceutics and biopharmaceu [Category] MERS, 진단, [키워드] activate affecting antibody Antigen Antigen presentation CD11c Cellular immune response Combination Compliance DCs dendritic cell effective Efficiency expected immune immune response immunization Immunoliposomes IMPROVE in vivo indicated induce inhibit Langerhans cell Langerhans cell targeting Liposome maturation Microneedle monoclonal monoclonal antibody novel produced promoted significantly stimulated survival Th1-biased immune response the epidemic Transcutaneous Transcutaneous immunization. tumor growth Vaccine [DOI] 10.1016/j.ejpb.2022.06.004 PMC 바로가기 [Article Type] Article
RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceSARS-CoV-2에 대한 2개의 항원 소단위 단백질 백신 후보인 RelCoVax®는 마우스에서 강력한 면역 반응을 유도합니다Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adjuvant adjuvants Administered alum aluminum aluminum hydroxide Antibody titer Antibody titers Antigen antigen exposure Cell Cellular immune response cellular immune responses Combination contribute COVID-19 pandemic CpG Delta delta variant demonstrated develop dominant dose regimen dual E. coli effective vaccine elicited Emergency use authorization evade evidenced glycoprotein heterologous expression hydroxide IFN-γ immune responses immunize immunized immunized mice in vitro induce mammalian cell mammalian cells mice Mutation N protein N proteins neutralize Neutralizing antibodies neutralizing antibody nucleocapsid prime and boost Protein RBD Receptor binding domain Region RelCoVax® S protein Safe SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus serum splenocyte splenocytes stimulated strain strong immune response subunit Subunit vaccine Th1 the SARS-CoV-2 virus vaccinated individuals Vaccine vaccine candidate vaccine candidates variants of SARS-CoV-2 viral strains virus entry [DOI] 10.1016/j.vaccine.2022.06.026 PMC 바로가기 [Article Type] Article
Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccineBNT162b2 mRNA 백신 2회 접종 후 6개월 동안 일본 의료 종사자의 항체 역가 및 세포 면역의 역학Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] All participant All participants Analysis antibody Antibody titer Antibody titers Asymptomatic BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Breakthrough infection breakthrough infections Cellular immune response cellular immune responses cellular immunity clinical trial collected conducted COVID-19 determinant determinants determine dose Dynamics elevated follow-up period healthcare healthcare worker Healthcare workers humoral IgG immune response immune responses incidence Japanese knowledge medical condition Medical conditions mRNA vaccine mRNA vaccines Nucleocapsid proteins of BNT162b2 participant Pfizer Pfizer-BioNTech positive prospective cohort study receiving SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine seroconverted serum sample serum samples study period T-cell immune response T-cell immune responses timepoint vaccination Vaccine waned were measured within 6 months [DOI] 10.1016/j.vaccine.2022.06.016 PMC 바로가기 [Article Type] Article
Codelivery of SARS-CoV-2 Prefusion-Spike Protein with CBLB502 by a Dual-Chambered Ferritin Nanocarrier Potentiates Systemic and Mucosal Immunity이중 챔버 페리틴 나노 캐리어에 의한 CBLB502와 SARS-COV-2 프리 펜션-스파이크 단백질의 코드 전달은 전신 및 점막 면역을 강화시킨다.Article Published on 2022-07-182022-08-31 Journal: ACS applied bio materials [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved Breakthrough infection breakthrough infections CBLB502 Cellular immune response codelivery contribute coronavirus dual-chambered elevated Factor ferritin ferritin nanocarrier IL-4 immune response immune responses Immunity Immunoglobulin Immunoglobulin G immunoglobulin G response inefficient INF-γ injection intramuscular Lower respiratory tract moderate mucosal mutant prefusion prefusion-spike respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly systemic systemic and local systemic and mucosal immunity. Trigger upper and lower respiratory tract upper respiratory tract Vaccine Vaccine development variants of SARS-CoV-2 [DOI] 10.1021/acsabm.2c00328 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic reviewSARS-Cov-2 오미크론 변이체에 대한 COVID-19 백신의 체액 및 세포 면역 반응: 전신 검토Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed B.1.1.529 booster booster dose cellular Cellular immune response cellular immune responses center contagious coronavirus 2 country COVID-19 vaccine Critical current dominant variant dose Effectiveness elicit elicited Future Genome Health Organization Heterologous homogenous homologous or heterologous humoral Humoral and cellular immune responses humoral immune response humoral immune response, cellular immune response immune Immune escape immune responses induce molecular basis multiple mutation multiple mutations mutated Mutation Neutralizing antibody response neutralizing antibody responses omicron Omicron variant PROTECT Protective public health question regimen regimens reported respiratory response robust S-protein SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Systemic review systemically T cell T cell response the SARS-CoV-2 virus vaccination Vaccination strategy Vaccine variant VoC WHO World Health Organization [DOI] 10.7150/ijbs.73583 PMC 바로가기 [Article Type] Review
mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primatesmRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA [DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article
CoVITEST: A Fast and Reliable Method to Monitor Anti-SARS-CoV-2 Specific T Cells From Whole BloodCoVITEST: 전혈에서 Anti-SARS-CoV-2 특정 T 세포를 모니터링하는 빠르고 신뢰할 수 있는 방법Article Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adjust antibodies Antibody detection automated Blood blood test can be used Cellular immune response cellular immunity cellular response comparable complex convalescent COVID-19 demonstrated determine diagnostic Donor ELISPOT Evidence explained gold gold standard healthy help house humoral immune response humoral immune responses IFN-γ IFN-γ ELISPOT immune protection immune responses Immune status IMPROVE individual less MONITOR pandemic Patient protocol Reinfection SARS-CoV-2 side simple Specific Support T cell T cells Test therapeutic approaches vulnerable patient vulnerable patients weakened immune system [DOI] 10.3389/fimmu.2022.848586 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID-19 vaccinationSARS-CoV-2-특이 T 세포는 COVID-19 백신 접종 후 혈청 전환에 실패한 동종 HSCT 수혜자의 절반 미만에서 생성됩니다Article Published on 2022-07-012022-09-12 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] allogeneic HSCT B-cell Cellular immune response COVID-19 vaccination HSCT HSCT patients Humoral response iatrogenic less majority Patient recipient SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells seroconvert Specific T-cell response T-cell responses vaccination [DOI] 10.1002/eji.202149771 PMC 바로가기 [Article Type] Article
Humoral Response to the Third Dose of Sars-Cov-2 Vaccine in Kidney Transplant RecipientsArticle Published on 2022-07-012022-11-15 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 진단, [키워드] administration analyzed anti-S antibody Antibody titers BNT162b2 mRNA vaccine BNT162b2 vaccine booster CD4 Cellular immune response Control correlated Decreased develop Donor dose doses Factors health care workers humoral IgG immune response in both groups increase in individual intracellular cytokine kidney kidney transplant recipients Lymphocyte count mononuclear cells MOST mRNA Older age Peripheral blood recipient required response Safe SARS-CoV-2 vaccine Serologic response seronegative seropositive significant increase significantly solid organ transplant TNFα Transplant [DOI] 10.1016/j.transproceed.2022.02.011 PMC 바로가기
In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening [DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article