Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors2082년 COVID-19 회복기 혈장 기증자의 증상, 기증자 특성 및 IgG 항체 반응 간의 연관성Observational Study Published on 2022-02-282022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] age Anosmia antibodies antibody Antibody Response association average body mass index CCP Characteristics concentrations convalescent plasma COVID COVID-19 COVID-19 symptom diarrhoea disease Donor donors dry cough Dyspnoea faster fatigue female Fever headache IgG IgG antibody less linear longitudinal male mixed-effects model MOST nasal outcome Patient performed questionnaire reported response retrospective SARS-CoV-2 antibody severity of COVID-19 Symptom Symptoms the SARS-CoV-2 unique weakness [DOI] 10.3389/fimmu.2022.821721 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron MetabolismSARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다Article Published on 2022-02-182022-09-10 Journal: Stem cell reviews and reports [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accompanied ACE2 receptor acute respiratory distress aggravate Alpha analyzed Anemia Bilirubin Blood Blood samples cause CD147 Cell cells Coagulopathies Coagulopathy concentrations contribute Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients death Degradation diagnostic differentiation door dysregulation erythroid Erythroid precursors expansion Express ferritin HAMP healthy donor healthy donors heme hemoglobin Hemoglobin biosynthesis Hemoglobin degradation hepcidin homeostasis hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia identify impair in vitro infect inhibit iron Iron metabolism mass spectrometry metabolism Mortality mRNA expression multiorgan failure opens oxygen Peripheral blood precursor progenitor qPCR analysis Raman Trapping Microscopy RBC RBCs Red red blood cell red blood cells reduced respiratory distress Result SARS-CoV-2 SARS-COV-2 infection serum Serum ferritin severe COVID-19 disease severely ill COVID-19 patients severity Spectroscopy stem cell stem cells susceptible Therapeutic strategies total bilirubin Transferrin variant were infected Whole blood Zinc [DOI] 10.1007/s12015-021-10322-8 PMC 바로가기 [Article Type] Article
Krebs von den Lungen-6 as Disease Severity Marker for COVID-19 Patients: Analytical Verification and Quality Assessment of the Tosoh AIA-360 Compared to Lumipulse G600IIKrebs von den Lungen-6, COVID-19 환자의 질병 심각도 지표: Lumipulse G600II와 비교한 Tosoh AIA-360의 분석 검증 및 품질 평가Article Published on 2022-02-152022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] an area analysed Analysis analytical validation article assessment AUC AUROC best Biomarker chemiluminescence comparable Concentration concentrations COVID COVID-19 COVID-19 patient COVID-19 patients cut-off value demonstrated detectable disease severity effective enzyme enzyme immunoassay evaluated fluorescent Fujirebio Hospitalized identify immunoassay interstitial pneumonia IQR Krebs von den Lungen-6 limit marker material median age non-severe patient non-severe patients Patient Quality reagent receiver reported Research ROC serum severe COVID-19 patients Siena significantly higher unit verification was measured [DOI] 10.3390/ijerph19042176 PMC 바로가기 [Article Type] Article
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patientsRandomized Controlled Trial Published on 2022-02-142022-10-04 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Abstract Administered administration affected approved caused Central nervous system Clinical improvement clinical trial CNS concentrations conducted COVID-19 COVID-19 patient Critical death defined Dexamethasone dose doses dysregulated Effectiveness Efficacy FIVE Glucocorticoids group health institution Hospitalization IMPROVE individual Inflammation intranasal intranasal administration intranasally intravenous intravenously low dose Mexico City moderate multi-organ dysfunction multicenter Neuroinflammation Open-label Patient patients Primary outcome protocol Randomized Randomized controlled trial recruited reduce reduce mortality reduction in mortality regimen respiratory tract secondary outcome severe COVID-19 severe COVID-19 patients statistically significant reduction systemic inflammation therapeutic therapeutic dose treated triggering two group [DOI] 10.1186/s13063-022-06075-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant CellsArticle Published on 2022-02-112022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] accumulate Analysis anti-SARS-CoV-2 antimalarial antimalarial drug Antiviral approved drug assays Calu-3 Calu-3 cell Cell cell line Chloroquine clinical benefit clinical trials clinically concentrations COVID-19 differential expression example HCQ Human IL-6 in vitro in vitro activity information inhibit inhibited Interaction investigated lack Lungs mechanism of action mefloquine modulated monocyte Monocytes optimal dose parameter pathway pharmacological plasma predicted prevented reduced Respiratory Coronavirus respiratory diseases SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication SARS-CoV-2 RNA solidarity therapeutic therapy TMPRSS2-expressing cells TNF-α type II pneumocytes virus entry were assessed [DOI] 10.3390/v14020374 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 in urban stormwater: An environmental reservoir and potential interface between human and animal sources도시 우수에서 SARS-CoV-2 감지: 환경 저수지 및 인간과 동물 출처 간의 잠재적 인터페이스Article Published on 2022-02-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Affect Characteristics city collected Concentration concentrations confirmed case confirmed COVID-19 case Contamination coronavirus correlated correlation COVID-19 detectable detection determine dominant E gene facilitate Factor fecal Fecal contamination Future hazard Human investigated microbial Microbial source tracking occurred one health pathway Pathways persistence Potential potential transmission SARS-CoV-2 SARS-CoV-2 E gene SARSCoV-2 significantly stormwater target gene the SARS-CoV-2 Transmission urban Urban runoff. viral outbreak virus Virus concentrations wastewater while [DOI] 10.1016/j.scitotenv.2021.151046 PMC 바로가기 [Article Type] Article
Role of Urinary Kidney Stress Biomarkers for Early Recognition of Subclinical Acute Kidney Injury in Critically Ill COVID-19 Patients중환자 COVID-19 환자에서 무증상 급성 신장 손상의 조기 인식을 위한 요로 신장 스트레스 바이오마커의 역할Article Published on 2022-02-082022-09-11 Journal: Biomolecules [Category] 바이오마커, [키워드] 95% CI acute kidney Acute kidney injury Admission AKI binding Biomarker Biomarkers clinical information clinical trials collected Combination Comorbidities concentrations contribute COVID-19 COVID-19 patient COVID-19 patients critical care area Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients develop Early detection Gender growth factor Hospitalization IGFBP7 Ill individual information insulin insulin like growth factor binding protein 7 kidney laboratory data longitudinal cohort study male Mortality neutrophil Neutrophil gelatinase-associated lipocalin on admission persistent proportion Protein Recognition risk factor Risk factors role significantly higher Stress study outcome study outcomes Subclinical Tissue Inhibitor tissue inhibitor of metalloproteinases-2 urinary urinary kidney stress biomarkers. were recorded with COVID-19 [DOI] 10.3390/biom12020275 PMC 바로가기 [Article Type] Article
Children and Adults With Mild COVID-19: Dynamics of the Memory T Cell Response up to 10 Months경증 COVID-19가 있는 어린이 및 성인: 최대 10개월까지 기억 T 세포 반응의 역동성Clinical Trial Published on 2022-02-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immunity Adults Analysis Antibody Response Antigen CD4 Cell cellular children Concentration concentrations contribute controls Coronavirus-2 correlated Course COVID-19 Cytokines detectable determine develop Dynamics effective effector memory ELISPOT exposure to frequencies heat heat-inactivated IFN-γ IFN-γ ELISPOT IgG immune memory infected children infections Longitudinal assessment marker memory T memory T cell Mild mild SARS-CoV-2 infection mild symptoms Mild-to-moderate moderate moderate symptoms Month Nucleocapsid proteins overlapping PBMC PBMCs peptide peptides performed Peripheral blood peripheral blood samples recall reduced Reinfection respiratory response Result SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells serum antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly Stimulation symptom onset Symptoms T cell T cell immunity T cell response T cells Th1 phenotype [DOI] 10.3389/fimmu.2022.817876 PMC 바로가기 [Article Type] Clinical Trial
Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing PredictionsCOVID-19를 치료하기 위해 에어로졸 화 클로로퀸 및 하이드 록시 클로로 퀴인의 폐 전달 : 인간 투약 예측에 대한 시험 관내 실험Research Article Published on 2022-02-072022-09-10 Journal: The AAPS Journal [Category] 신약개발, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aerosol Aerosols bronchial epithelial cell Cell cell viability characterized Chloroquine Clinical significance Concentration concentrations coronavirus COVID-19 delivery dose Dosing drug effective Efficacy electrical resistance epithelial cells evaluated exposure to Human humans Hydroxychloroquine in vitro inhalation Inhaled Local lung lysosomal oral administration PBPK pharmacokinetic pharmacokinetics pharmacological physicochemical property predicted prediction primary human bronchial epithelial cells pulmonary respiratory respiratory tract SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant changes in supplementary material target tissue thermal these compound these compounds tissue Toxicity transepithelial electrical resistance treat viability [DOI] 10.1208/s12248-021-00666-x PMC 바로가기 [Article Type] Research Article
Humoral immune response to COVID-19 mRNA vaccination in relation to selenium statusObservational Study Published on 2022-02-032022-10-04 Journal: Redox Biology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] Abstract anti-SARS-CoV-2 vaccination antibody association baseline Biomarker Biomarkers blood sample BNT162b2 cohort study collected Concentration concentrations correlated COVID-19 mRNA Vaccination disease severity first dose Glutathione peroxidase had no Health Health care worker healthy highest humoral immune response Image immune response immune system mortality risk neutralising Neutralising activity neutralising antibody pandemic participant patients with COVID-19 peroxidase quantified reported SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 vaccination SARS-CoV-2 vaccines Se deficiency second dose Selenium Selenoprotein P serum significantly titre titres vaccination Vaccine [DOI] 10.1016/j.redox.2022.102242 PMC 바로가기 [Article Type] Observational Study