Wastewater-based epidemiological surveillance to monitor the prevalence of SARS-CoV-2 in developing countries with onsite sanitation facilitiesArticle Published on 2022-10-152022-11-15 Journal: Environmental pollution (Barking, Essex : 1987) [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] absence approach collected Complete Contagion correlation country COVID-19 COVID-19 pandemic Critical detect Developing developing countries disease drain epidemiological Epidemiology facilitate genetic component genetic material help highest identification investigated Isolation MONITOR N genes National National surveillance program Onsite sanitation ORF1ab outbreak pandemic positive Prevalence reported RT-qPCR Rural Hotspot based sampling sampling SARS-CoV-2 SARS-CoV-2 monitoring SARS-CoV-2 RNA service Surveillance urban Urban Drain based sampling viral copy number wastewater-based epidemiology (WBE) were used [DOI] 10.1016/j.envpol.2022.119679 PMC 바로가기
COVID-19 prevalence and infection control measures at homeless shelters and hostels in high-income countries: a scoping reviewArticle Published on 2022-10-152022-11-16 Journal: Systematic Reviews [Category] 변종, [키워드] absence Analysis applied assessment Asymptomatic conducted country COVID-19 COVID-19 outbreak COVID-19 pandemic Critical database demographics disease events Evidence exclusion Factor global health Health Homeless population Homeless shelters impacted implementation infection control limitation mapped measure Measures offer outbreak outcome people experiencing homelessness populations portal Prevalence prevalence of COVID-19 prevention protocol public health Registered Research screened Shelter workers. Spread the WHO university variant York [DOI] 10.1186/s13643-022-02089-x PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral EntryArticle Published on 2022-10-142022-11-16 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 binding binding pocket block blocked broad inhibitor candidate cell-cell fusion cellular circulating SARS-CoV-2 variant Compound conformational change conserved coronavirus Critical Entry inhibitor entry inhibitors entry pathway facilitate function glycoprotein host cell Infection inhibitory effect interfere mode of action plasma membrane receptor Receptor binding domain required Ring SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike selective significantly Small molecules spike subsequent tested the SARS-CoV-2 these compound Tricyclic Trigger viral entry viral spike [DOI] 10.1021/acsinfecdis.1c00658 PMC 바로가기
Prevalence and coagulation correlation of anticardiolipin antibodies in patients with COVID-19Article Published on 2022-10-142022-11-15 Journal: Medicine [Category] 진단, [키워드] activated Analysis analyzed antibody Characteristics Coagulation coagulative coronavirus disease correlation COVID-19 COVID-19 patients Critical Critically ill patient critically ill patients determine IgA IgG ill patient isotype Laboratory much higher non-critically ill patients occurred Patient patients with COVID-19 Prevalence serum significant difference thrombin thrombosis variable [DOI] 10.1097/MD.0000000000031040 PMC 바로가기
PrimedSherlock: a tool for rapid design of highly specific CRISPR-Cas12 crRNAsArticle Published on 2022-10-142022-11-15 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] assays automated benefit bioinformatics Cas12 nuclease assay Cas12a Combination conserved CRISPR CRISPR-Ca CRISPR-Cas12 Critical demonstrated Dengue diagnostic diagnostics Efficiency facilitated FDA approval field Field forward diagnostics flavivirus genomes genomic HIV In-vitro Intensive isothermal isothermal amplification manual curation Nile nucleases nucleic acid offer parameter Pathogens platform polymorphism PrimedRPA PrimedSherlock primer primer pair Primers qRT-PCR regions RNA robust SARS-CoV-2 Serological assay serotype SHERLOCK significantly specificity strain Strains target targets Vector-borne disease West West Nile wildtype Zika Zika. [DOI] 10.1186/s12859-022-04968-5 PMC 바로가기
The impact of vaccine hesitation on the intentions to get COVID-19 vaccines: The use of the health belief model and the theory of planned behavior modelArticle Published on 2022-10-142022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Affect affecting conducted covariate COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical cross-sectional Factor Factors group HBM HBM (health belief model) Health Healthcare provider help Intention Intervention MOST Multiple linear regression perceived benefit proportion receive recruited risk Self-efficacy Standard deviation survey platform T-tests the vaccine TPB (theory of planned behavior) vaccinated against COVID-19 vaccination vaccination intention vaccination intentions Vaccine vaccine hesitation. variant were expressed were used [DOI] 10.3389/fpubh.2022.882909 PMC 바로가기
Quantifying Mutational Response to Track the Evolution of SARS-CoV-2 Spike Variants: Introducing a Statistical-Mechanics-Guided Machine Learning MethodArticle Published on 2022-10-132022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied Affect Analysis approach average binary classification model characteristic concern Critical database defined Evolution function global public health help identify implication information interest machine learning Mutation mutations pathogenicity predict residue response SARS-CoV-2 sequence spike spike glycoprotein Stage statistical track variant virus VoC VOCs VOIs [DOI] 10.1021/acs.jpcb.2c04574 PMC 바로가기
Comparative Analysis of Antibody Titers against the Spike Protein of SARS-CoV-2 Variants in Infected Patient Cohorts and Diverse Vaccination RegimesArticle Published on 2022-10-132022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied antibody Antibody Response AstraZeneca B cell benefit booster vaccination cells Comparative courses COVID-19 COVID-19 pandemic Critical critical COVID-19 patients exceeded follicular Frequency Infection Inflammation Inflammatory response Johnson & Johnson long-COVID Lymphocytes Mild Moderna mRNA vaccine neutralizing antibody patients patients who survived Pfizer-BioNTech recommendation reduced regime SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 disease the SARS-CoV-2 virus the Spike titer understanding vaccination Vaccination strategy Vaccine [DOI] 10.3390/ijms232012231 PMC 바로가기
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low ToxicityArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-SARS-CoV-2 antiviral activity antiviral agent binding caspase 3 cathepsin Critical cytotoxicity derivative direct-acting drug design exhibit inhibit inhibitor interactions M pro piperazine protease SARS-CoV-2 Spread Structure target therapy for COVID-19 variants X-ray [DOI] 10.1021/acs.jmedchem.2c01146 PMC 바로가기