Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)Research Article Published on 2021-01-082022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] acute respiratory distress airway alleviate antiviral agent ARDS Bank COVID-19 drug Drug repurposing drugs exploration faster hACE2 hACE2 receptor human Angiotensin-converting enzyme immune system in vitro in vivo indication Infection Inflammation Influenza virus inhibit inhibitor Interaction investigated modulate molecular molecular docking pandemic peptide peptide-based pharmacological potential benefit predict predicted Prevent protein-protein interaction receptor reduced Regulatory required SARS-CoV-2 spike protein specificity Spike protein stimulate Support syndrome the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Treatment viral infection [DOI] 10.1371/journal.pone.0245258 PMC 바로가기 [Article Type] Research Article
A Nosological Exploration of PTSD and Trauma in Disaster Mental Health and Implications for the COVID-19 PandemicPerspective Published on 2021-01-082022-10-28 Journal: Behavioral Sciences [Category] COVID-19, [키워드] article consequence Consequences coronavirus disease COVID-19 COVID-19 pandemic criteria Diagnosis diagnostic Diagnostic Criteria disaster disorder essential element exploration exposure medical illness mental health morbidity and mortality nosology option outcome outcomes pandemic Population post-traumatic posttraumatic stress disorder problem provide Psychiatric psychiatric diagnosis criteria psychiatric disorder Psychiatric disorders PTSD reported Research resulting Spread Stress symptomatic syndrome trauma [DOI] 10.3390/bs11010007 PMC 바로가기 [Article Type] Perspective
Computational and theoretical exploration for clinical suitability of Remdesivir drug to SARS-CoV-2SARS-CoV-2에 대한 렘데시비르 약물의 임상적 적합성에 대한 전산 및 이론 탐색Review Published on 2021-01-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 치료제, [키워드] Analysis atmospheric pressure clinical trials dynamic exploration free energy Gibb's free energy Gromacs inhibitor interactions methodology molecular dynamic simulations molecular dynamics protease Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2 protein thermodynamic Thermodynamic potentials. Treatment Variation [DOI] 10.1016/j.ejphar.2020.173642 PMC 바로가기 [Article Type] Review
COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenarioCOVID-19 및 악성 종양: 가능한 유전적 및 후성 유전적 상호 연결의 탐색 및 예방 접종 시나리오의 개요Review Published on 2021-01-012022-09-11 Journal: Cancer treatment and research communications [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, 임상, [키워드] ACE2 alteration Cancer cancer patient Cancer patients cause clinical clinical parameter Clinical parameters Clinical studies conducted contribute COVID-19 cytokine Cytokines death demonstrated epidemiological studies Epidemiological study Epigenetic exacerbating exploration Genetic IL-6 malignancy malignant mechanism Modification Mortality Patient patient cohort relationship Research SARS-CoV-2 SARS-COV-2 infection severe complication severe complications TMPRSS2 vaccination Vaccine vulnerability [DOI] 10.1016/j.ctarc.2021.100425 PMC 바로가기 [Article Type] Review
Alpha-1 antitrypsin for cystic fibrosis complicated by severe cytokinemic COVID-19중증 세포운동성 COVID-19에 의해 복잡한 낭포성 섬유증에 대한 알파-1 항트립신Case Reports Published on 2021-01-012022-09-11 Journal: Journal of cystic fibrosis : official journal of t [Category] MERS, SARS, 바이오마커, [키워드] Administered airway Alpha alpha-1 antitrypsin Anti-inflammatory antitrypsin baseline baseline levels Clinical course coronavirus COVID-19 Cystic cystic fibrosis Cytokinemia decrease dose exploration fibrosis IL-1β IL-6 IL-8 Inflammation Inflammatory Inflammatory marker interleukin interleukin-1β interleukin-6 interval Level lung lung transplantation neutrophil Neutrophil elastase Neutrophil elastase. parameter Patient plasma Radiographic receptor severe COVID-19 Support systemic therapeutic therapy TNF were assessed [DOI] 10.1016/j.jcf.2020.11.012 PMC 바로가기 [Article Type] Case Reports
Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing StudySARS-CoV-2 주요 프로테아제 표적화: 컴퓨터 약물 용도 변경 연구Article Published on 2021-01-012022-08-31 Journal: Archives of medical research [Category] SARS, 신약개발, 치료제, [키워드] 6LU7 acute respiratory syndrome acute respiratory syndrome coronavirus-2 approach approved approved drug aprepitant arbutin barnidipine clinically coronavirus disease COVID-19 Dexamethasone docked docking docking score docking scores docking tool drug Drug discovery Drug repurposing drug-target DrugBank drugs electrostatic interactions exploration Favipiravir FIVE hydrophilic hydrophobic in silico in viral inhibit Ligand limitation M pro M(pro) management molecular molecular dynamics molecular dynamics simulations molecular interaction novel Novel coronavirus novel coronavirus disease pandemic protease Protein Remdesivir Replication reported repurposing researcher respiratory SARS-CoV-2 Schrodinger Severe acute respiratory syndrome Standard Structure targeting targets terbutaline tipiracil Treatment US-FDA Vaccine development Viral viral replication Virtual screening [DOI] 10.1016/j.arcmed.2020.09.013 PMC 바로가기 [Article Type] Article
Multi-resolution visualization and analysis of biomolecular networks through hierarchical community detection and web-based graphical tools계층적 커뮤니티 감지 및 웹 기반 그래픽 도구를 통한 생체 분자 네트워크의 다중 해상도 시각화 및 분석Research Article Published on 2020-12-222022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, 치료제, [키워드] Algorithm Analysis approach case study centric Community complex complex interaction conducted connectivity correlated correlation enrichment analyses enrichment analysis exploration feasible functional group hidden Hierarchical hierarchy human host Interpretation introduced performed Protein Proteins SARS-CoV2 shown user Visualization web application [DOI] 10.1371/journal.pone.0244241 PMC 바로가기 [Article Type] Research Article
Deciphering the Pharmacological Mechanisms of Ma Xing Shi Gan Decoction against COVID-19 through Integrating Network Pharmacology and Experimental ExplorationPharmacology Published on 2020-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Adsorption analyzed Anti-inflammatory effects Antiviral caused Clinical symptoms component COVID-19 Critical Cytokine storm Decoction disease Efficacy exploration immune immunomodulatory Inflammation inflammatory lung injury Influenza inhibit inhibiting Intervention Lung injury Ma Xing Shi Gan decoction mechanism Medicine network network pharmacology outbreak pathway pharmacological mechanism Pharmacology Pneumonia Prevent public health Regulatory replication of SARS-CoV-2 Research Safe SARS-CoV-2 signaling pathway Tandem mass spectrometry targets TCM the epidemic therapeutic effect Toll-like receptor Traditional Chinese medicine Transcriptome treating COVID-19 Treatment Vaccine viral entry Viral pneumonia virus infection [DOI] 10.3389/fphar.2020.581691 PMC 바로가기 [Article Type] Pharmacology
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible MechanismsReview Published on 2020-11-132022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] β-cell apoptosis accelerate accelerated ACE2 acute respiratory syndrome advanced age amylin Apoptosis blood glucose caused cellular co-morbidity Complication complications Coronavirus-2 COVID-19 develop disease dysfunction elevated exploration fibrosis Gender Glucose help hypertension Immediate Inflammation Injury insulin resistance islet islet amyloid male metabolic syndrome Microscopy novel coronavirus disease obesity observation oxidative stress pancreatic pandemic renin–angiotensin–aldosterone-system responsible role SARS-CoV-2 severity of COVID-19 Stress syndrome the WHO tissue tissues Type type 2 diabete [DOI] 10.3390/cells9112475 PMC 바로가기 [Article Type] Review
New Ways of Working? A Rapid Exploration of Emerging Evidence Regarding the Care of Older People during COVID19Article Published on 2020-09-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis article Care conducted COVID-19 COVID-19 pandemic COVID19 database England evaluate Evidence exploration Germany Health Health and social care IMPROVE include integrated care Ireland Local New new ways of working Older older people pandemic Perspective Rapid researchers resource respond social media Teamwork thematic analysis [DOI] 10.3390/ijerph17186442 PMC 바로가기 [Article Type] Article