Early indicators of microbial strain dysbiosis in the human gastrointestinal microbial community of certain healthy humans and hospitalized COVID-19 patients Research Published on 2022-04-212022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, 치료법, [키워드] Analysis Bacteroide Cluster colonization resistance Community COVID-19 detect Dysbiosis eight examined Fecal sample Gut healthy high-density hospitalized COVID-19 patient hospitalized patient Human individual individuals intrinsic KEGG majority metabolic pathway metabolism metagenomic microbes microbial microbial community Pathogens Patient patients hospitalized PKS selected unique Variation with COVID-19 [DOI] 10.1038/s41598-022-10472-w [Article Type] Research
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
Intensive-Dose Tinzaparin in Hospitalized COVID-19 Patients: The INTERACT Study입원한 COVID-19 환자의 집중 용량 Tinzaparin: INTERACT 연구Observational Study Published on 2022-04-072022-09-12 Journal: Viruses [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] Activation Administered Admission adverse outcome anticoagulation bleeding event clinical clinical effectiveness coagulation cascade coronavirus COVID-19 COVID-19 patient CRP levels current D-dimer D-dimer level death Deep venous thrombosis diagnosed discharge dose DVT evaluate favor Greece hospital Hospitalized hospitalized COVID-19 patient hypercoagulability increasing age initiated intermediate dose Laboratory low molecular weight Low molecular weight heparins median age median treatment duration men moderate disease Mortality non-critically ill patient Observational cohort study occurred oxygen saturation participant participated Patient pharmacological Platelet pro-inflammatory progression Prophylactic prophylactic dose Prophylaxis receive retrospective SARS-CoV-2 severity therapeutic Thromboprophylaxis thrombosis thrombotic event tinzaparin tinzaparin. Venous Thromboembolism VTE were recorded WHO with COVID-19 World Health Organization [DOI] 10.3390/v14040767 PMC 바로가기 [Article Type] Observational Study
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytesD-이량체 및 CoV-2 스파이크-면역 복합체는 단핵구에서 PGE2 및 전염증성 사이토카인 생성에 기여합니다Article Published on 2022-04-062022-09-12 Journal: PLoS Pathogens [Category] 진단, [키워드] accelerate activated antibody binding antibody Calcium signaling chimeric Coagulopathy coated with Combination complexes contribute convalescent plasma correlated COVID-19 cytokine D-dimer dose healthy healthy donors hospitalized COVID-19 patient hospitalized COVID-19 patients human monocyte IL-6 IL-8 immune complex increase in infiltrating monocyte Inflammatory cytokine Inflammatory cytokines inflammatory status inhibitor integrin kinase lung Lung pathology MAPK monoclonal antibody monocyte much lower neutralizing antibody titers overreactive inflammatory response pathway Patient PGE2 plasma produced Proinflammatory cytokine prostaglandin E2 pseudovirus recombinant S protein regions responses S protein SARS CoV-2 significantly Treatment viral particle [DOI] 10.1371/journal.ppat.1010468 PMC 바로가기 [Article Type] Article
The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial입원한 COVID-19 환자(BeeCovid2)의 보조 치료제로 표준화된 브라질 녹색 프로폴리스 추출물(EPP-AF)의 사용: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Article Published on 2022-04-042022-09-11 Journal: Trials [Category] 임상, [키워드] 1:1 2019 coronavirus disease ACE2 acute COVID-19 Acute kidney injury adjunct Administered adults hospitalized Affect affected age anti-inflammatory agents association Bacterial balloon pump Brazil Cancer patients chronic disease Chronic diseases Chronic kidney disease clinical study conducted coronavirus disease COVID-19 demonstrated diagnosis of COVID-19 double-blinded ECMO Effectiveness Evidence experimental evidence extracorporeal membrane oxygenation Fungal infection groups heart failure HIV patients Hospital stay hospitalized COVID-19 patient hospitalized patients immunoregulation Immunosuppression impacts impossibility include Infection intra-aortic balloon pump Kidney disease Liver disease mechanical ventilation medication moderate moderate to severe outcome PAK1 PAK1 blocker pandemic Patient patients hospitalized Placebo placebo-controlled clinical study pregnant women Primary outcome Propolis protocol randomization Randomized Randomized controlled trial receive reducing renal replacement therapy replacement therapy secondary Secondary infection Secondary outcomes severe liver disease Spread standard care Study protocol Symptom targets TMPRSS2 Treatment Trial vasoactive drugs with COVID-19 [DOI] 10.1186/s13063-022-06176-1 PMC 바로가기 [Article Type] Article
Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patientsShort communication Published on 2022-04-012022-10-05 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied association class correlation COVID-19 COVID-19 hospitalization Critically ill genetic marker Genome GWAS Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients independent initiative instrumental variable mendelian randomization obesity objective Patient platform reported Research design Result risk risk factor shown T2D type 2 diabete type 2 diabetes was performed [DOI] 10.1016/j.metabol.2022.155156 [Article Type] Short communication
Hepatitis B and C screening in hospitalized patients with SARS-CoV-2 infectionSARS-CoV-2 감염으로 입원한 환자의 B형 및 C형 간염 검사Article Published on 2022-04-012022-09-11 Journal: Gastroenterología y hepatología [Category] B형 간염, COVID19(2023년), SARS, 진단, 치료기술, [키워드] age Anti-HCV Antiviral treatment antiviral treatments candidate Comorbidities conducted Corticosteroid Corticosteroids COVID-19 Cribado Diagnosis diagnosis of COVID-19 died evaluate expected HBsAg HBV HBV infection HCV Hepatitis hepatitis B hepatitis C hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitals immunosuppressive Infection less limit male marker median age Older Patient patients with COVID-19 positive Prevalence Prevent previous diagnosis Prophylaxis Prospective Study Reactivation receive RNA SARS-CoV-2 SARS-COV-2 infection Screening screening program Spanish tested treated Treatment [DOI] 10.1016/j.gastrohep.2021.09.002 PMC 바로가기 [Article Type] Article
Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 RegistryObservational Study Published on 2022-04-012022-10-04 Journal: Internal and Emergency Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] Acetylsalicylic acid Admission affected Analysis analyzed Cardiovascular disorders collected coronavirus COVID-19 COVID-19 patients determine evaluate evaluated group Health Hospital admission hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU admission in-hospital mortality Inflammation intensive care large sample Mortality no difference outcome Patient patients with COVID-19 Pneumonia Propensity score Protective protective role PSM receiving registry retrospective cohort study Spanish symptomatic thrombosis Treatment was performed [DOI] 10.1007/s11739-021-02870-1 PMC 바로가기 [Article Type] Observational Study
Study of the effects of interferon β-1a on hospitalized patients with COVID-19: SBMU Taskforce on the COVIFERON study입원한 COVID-19 환자에 대한 인터페론 β-1a의 효과 연구: COVIFERON 연구에 대한 SBMU 태스크포스Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] addition Antiviral conducted control group coronavirus disease Coronavirus disease 2019 COVID-19 died Effect Efficacy group hospital Hospital admission Hospital stay Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients IFN-β1a immunomodulatory functions IMPROVE indicated innate immune system interferon Interferon β-1a interferons Iran median Mortality mortality rate no statistically significant difference outcome P-value Patient patients treated progression Randomized controlled trial regimen Retrospective study selected Severe case severe cases severe COVID-19 standard care standard treatment statistically statistically significant difference Tehran the interferon two group two groups [DOI] 10.1002/jmv.27475 PMC 바로가기 [Article Type] Article
Elevated plasma levels of CXCL16 in severe COVID-19 patients중증 COVID-19 환자에서 CXCL16의 혈장 수준 상승Clinical Trial Published on 2022-04-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] association baseline benefit Cell cellular chemotaxis clinical trial Cohort collected controls COVID-19 CXCL16 CXCR6 defined determine disease elevated Genome-wide association studies homing hospitalized COVID-19 patient hospitalized patient hospitalized patients Immunopathogenesis Injury interact Ligand locus lung Lung infection Lungs motif P-value Pathogenesis Patient plasma plasma concentration plasma concentrations Plasma levels reported risk severe COVID-19 severe COVID-19 patient severity of COVID-19 Support susceptibility T cell T cells variant were assessed WHO Whole genome sequencing whole-genome sequencing [DOI] 10.1016/j.cyto.2022.155810 PMC 바로가기 [Article Type] Clinical Trial