Prevalence and Clinical Impact of Coinfection in Patients with Coronavirus Disease 2019 in Korea코로나 바이러스 질병 2019에서 코로나 바이러스 질환 환자의 유병률 및 임상 영향Article Published on 2022-02-212022-09-10 Journal: Viruses [Category] MERS, 치료기술, [키워드] Acinetobacter Analysis antimicrobial susceptibility Bacteria Candida albican Candida albicans carbapenem clinical Coinfection collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Culture death detect elevated lactate dehydrogenase Escherichia coli fungi hospitalized COVID-19 patients hospitalized patient hospitalized patients Impact Infection Lactate lactate dehydrogenase management Mortality Multivariate analysis Odds ratio Older age outcome pandemic pathogen Pathogens performed Prevalence Pseudomonas aeruginosa Real-time PCR resistance respiratory respiratory syncytial virus respiratory virus respiratory viruses rhinovirus risk factor Risk factors SARS-CoV-2 Screening significantly survival susceptibility virus viruses [DOI] 10.3390/v14020446 PMC 바로가기 [Article Type] Article
Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 PatientsArticle Published on 2022-02-192022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] Acinetobacter addition antibiotic Antibiotics antimicrobial resistance Antimicrobial stewardship association Bacteria Bacterial bacterial co-infection Bacterial infections chest pain clinical Co-infections cocci collected Compliance conducted COVID-19 COVID-19 patient death rate Diagnosis disease symptoms Dyspnea E. coli employment fatigue Fever hospital hospital-acquired infections hospitalized COVID-19 patient hospitalized COVID-19 patients incidence Klebsiella pneumoniae Laboratory majority MOST MRSA pathogenesis of SARS-CoV-2 patients positive Prevalence progression Pseudomonas aeruginosa Rate resistance rod SARS-CoV-2 SARS-COV-2 infection Severity of infection Staphylococcus aureus Streptococcus pyogene Symptom tested [DOI] 10.3390/antibiotics11020276 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron MetabolismSARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다Article Published on 2022-02-182022-09-10 Journal: Stem cell reviews and reports [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accompanied ACE2 receptor acute respiratory distress aggravate Alpha analyzed Anemia Bilirubin Blood Blood samples cause CD147 Cell cells Coagulopathies Coagulopathy concentrations contribute Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients death Degradation diagnostic differentiation door dysregulation erythroid Erythroid precursors expansion Express ferritin HAMP healthy donor healthy donors heme hemoglobin Hemoglobin biosynthesis Hemoglobin degradation hepcidin homeostasis hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia identify impair in vitro infect inhibit iron Iron metabolism mass spectrometry metabolism Mortality mRNA expression multiorgan failure opens oxygen Peripheral blood precursor progenitor qPCR analysis Raman Trapping Microscopy RBC RBCs Red red blood cell red blood cells reduced respiratory distress Result SARS-CoV-2 SARS-COV-2 infection serum Serum ferritin severe COVID-19 disease severely ill COVID-19 patients severity Spectroscopy stem cell stem cells susceptible Therapeutic strategies total bilirubin Transferrin variant were infected Whole blood Zinc [DOI] 10.1007/s12015-021-10322-8 PMC 바로가기 [Article Type] Article
Clinical Evidence Informing Treatment Guidelines on Repurposed Drugs for Hospitalized Patients During the Early COVID-19 Pandemic: Corticosteroids, Anticoagulants, (Hydroxy)chloroquine초기 CovID-19 Pandemic 동안 입원 환자를위한 용도로 된 약물에 대한 치료 지침에 대한 임상 증거 : 코르티코 스테로이드, 항응고제, (Hydroxy) 클로로퀸Review Published on 2022-02-182022-08-31 Journal: Frontiers in Public Health [Category] COVID19(2023년), meta-analysis, SARS, 임상, [키워드] adoption Analysis Anticoagulants best Chloroquine clinical Clinical data clinical evidence Clinical studies clinical study clinical trials Coagulopathy competing conducted coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 drug Efficacy and safety evaluated Evidence evidence generation Factor Factors Germany guideline Health Organization hospital hospitalized COVID-19 patient hospitalized COVID-19 patients hydroxy identify incorporation Inflammation Informing International meta-analyses Meta-analysis MOST National national treatment observational studies pandemic Patient care platform Platform trial platform trials protocol provided question randomized clinical trial RCT RCTs recommendations referred to Repurposed drug Repurposed drugs researcher Result retrospective cohort retrospective cohort study robust scientific rigor severely ill patient severely ill patients Spread Treatment treatment guideline treatment guidelines trials United State United States Viral viral replication WHO World Health Organization [DOI] 10.3389/fpubh.2022.804404 PMC 바로가기 [Article Type] Review
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lungDiltiazem은 SARS-CoV-2 세포 부착 및 내재화를 억제하고 마우스 폐의 바이러스 감염을 감소시킵니다Research Article Published on 2022-02-172022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] ACE2 Affect affecting anti-SARS-CoV-2 antiviral drug antiviral drugs appear approved attachment Author binding blocker Breakthrough infection breakthrough infections calcium calcium channel Cell Clinical practice coronavirus COVID-19 COVID-19 treatment decrease Diltiazem drug drugs Effectiveness Emergency use FDA-approved drug highlight hospitalized COVID-19 patients indications inhibit interact internalization L-type lung occurred raise recipient recipients Remdesivir Research research and development respiratory Respiratory Coronavirus Safe SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory coronavirus Spike protein subunit Support the vaccine the vaccines treat Treatment US FDA variant variants variants of SARS-CoV-2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010343 PMC 바로가기 [Article Type] Research Article
Outcomes of Hospitalized Patients With COVID-19 With Acute Kidney Injury and Acute Cardiac InjuryCardiovascular Medicine Published on 2022-02-152022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Accuracy ACI Acute cardiac injury Acute kidney injury adjusted AKI analyzed cardiac cardiac injury cardiovascular sequelae clinical outcomes collected common Comorbidities COVID-19 COVID-19 patient death discharge disease course groups had more Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients identify immunological incidence Inflammatory Injury Intervention investigated kidney Laboratory laboratory data Laboratory test liver longitudinal marker men Mortality MOST New York Odds ratio Older outcome Patient predict predicted Predictive Predictive model predictor Result Retrospective study risk Risk factors SARS-CoV-2 significantly System variable vitals were used [DOI] 10.3389/fcvm.2021.798897 PMC 바로가기 [Article Type] Cardiovascular Medicine
The Impact of Vitamin D Status on COVID-19 Severity among Hospitalized Patients in the Western Region of Saudi Arabia: A Retrospective Cross-Sectional StudyArticle Published on 2022-02-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% confidence interval adjusted Admission age analyzed approved association Chronic kidney disease CKD Clinical characteristics coronavirus covariance COVID-19 cross-sectional determine diabetes disease drug Evidence Faisal Gender hospital hospitalized COVID-19 hospitalized COVID-19 patients hypertension ICU ICU admission Impact infection and immunity intensive care King Laboratory test mechanical ventilation Mortality multicenter multiple logistic regression Ratio Region retrospective Saudi Arabia serum severity shown specialist Spread statistically significant status study population Support the disease therapy Vaccine Vitamin D vitamin D deficiency Vitamin D status Vitamin D supplementation was used were recorded [DOI] 10.3390/ijerph19031901 PMC 바로가기 [Article Type] Article
In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma ProductionArticle Published on 2022-02-072022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Analysis CD3 CD3+ CD4/CD8 CD4+ CD8+ Characteristics COVID-19 COVID-19 patients demonstrated gold GraphPad Prism hospitalized COVID-19 patient hospitalized COVID-19 patients IFN IFN-γ IGRA increase Increased independent predictor indeterminate lymphopenia median multivariable analysis non-survivor Non-survivors oxygen supply Patient patients patients hospitalized peripheral Peripheral blood positive correlation Prevalence Production QuantiFERON-TB Gold Rate Reflecting required Retrospective study SARS-CoV-2 severe cases severe COVID-19 patient stratified survivor T-cell T-lymphocyte to define was performed [DOI] 10.3390/life12020244 PMC 바로가기 [Article Type] Article
Hidden fraction of Polish population immune to SARS-CoV-2 in May 20212021년 5월에 SARS-CoV-2에 면역된 폴란드 인구의 숨겨진 부분Research Article Published on 2022-02-032022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Anti-RBD IgG anti-SARS-CoV-2 antibodies Antigen antigens Asymptomatic can not collected convalescent COVID-19 COVID-19 pandemic cross-reactivity diagnosed estimation exclusion fraction HCoV HCoV 229E healthy individual healthy individuals herd immunity hospitalized COVID-19 patient hospitalized COVID-19 patients IgA IgA antibodies IgA antibody IgG immune Immunity individual Infection infections investigated Lower majority MERS-CoV modeling NL63 other coronaviruses pandemic Patient patients Population population immunity Population screening positive positive controls Protein public health Quantitative RBD Registered SARS-CoV SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2-specific IgG sera serum sample serum samples spike subject tested vaccination vaccination against COVID-19 Vaccinations virus virus-neutralizing Virus-specific IgG [DOI] 10.1371/journal.pone.0253638 PMC 바로가기 [Article Type] Research Article
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illnessResearch Article Published on 2022-02-032022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 25-hydroxyvitamin D3 95% confidence interval association category center change clinical outcomes correlation COVID-19 COVID-19 infection COVID-19 severity Critical disease deficiency demonstrated disease severity GMC hospitalized COVID-19 patients increased risk individual infection with SARS-CoV-2 Mild moderate disease Mortality multivariable objective Odds ratio participant Patient PCR polymerase chain positive positive PCR test regression analysis Result Retrospective study SARS-CoV-2 searched serum 25-hydroxyvitamin D severity of COVID-19 Vitamin D status was used with COVID-19 [DOI] 10.1371/journal.pone.0263069 PMC 바로가기 [Article Type] Research Article