innate immune system – Page 8 – Communicable Diseases Research

Homology between SARS CoV-2 and human proteins

Article

Published on 2021-08-252022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

Immune System Disequilibrium—Neutrophils, Their Extracellular Traps, and COVID-19-Induced Sepsis

Medicine

Published on 2021-08-182022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range

비강 점막의 면역 세포 거주는 연령대의 호흡기 질환 심각성을 부분적으로 설명 할 수 있습니다.

Article

Published on 2021-08-052022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Adults age analyzed antiviral properties applied Cell cell type cellular changes in children correlated COVID-19 severity epigenome epithelial cell epithelial cells Evidence explain Functional genomics generate healthy individual healthy individuals immune immune activation Immune cell immune cell type immunization strategies individual infection with SARS-CoV-2 innate immune response innate immune system Mucosal immunology nasal nasal mucosa Previous studies previous study proportion reflect resource respiratory Respiratory disease respiratory infection robust SARS-CoV-2 Sequencing severity Single-cell RNA-sequencing suggested T cell transcriptional underlie uninfected
[DOI] 10.1038/s41598-021-95532-3 PMC 바로가기 [Article Type] Article

Pattern recognition receptors in health and diseases

Review Article

Published on 2021-08-042022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] 치료제,

[키워드] adaptor molecule anti-infection apoptotic binding Characteristics clinical therapy clinical trial CLRs composed damaged disease Diseases domain domains downstream signaling pathway drug Drug development Effects FIVE Health host cells immune-related disease Immunity innate immune system Innate immunity Ligand ligands mechanism molecular MOST NLRs nonspecific nucleotide oligomerization Pathogens Pattern recognition promoted Protein provided PRR PRRs receptor recognize recruit Research RLRs senescent cells signaling pathway structural biology Structure TLRs Toll-like receptor Treatment tumors Vertebrate
[DOI] 10.1038/s41392-021-00687-0 PMC 바로가기 [Article Type] Review Article

Molecular determinants of disease severity in urinary tract infection

요로 감염에서 질병 중증도의 분자적 결정인자

Review

Published on 2021-08-012022-09-12
Journal: Nature reviews. Urology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] acute pyelonephritis aggression approach asymptomatic bacteriuria Bacteria Bacterial bacterial pathogen bladder caused COVID-19 pandemic defined determinant disease disease severity function Health Host host immune system host response host susceptibility immune response immune responsiveness Infection inhibiting innate immune innate immune activation innate immune system Innate immunity kidney infection Measures microbial modify morbidity morbidity and mortality observation outcome Pathogens provide responsible severe disease severity susceptible patients symptomatic therapeutic Treatment urinary tract infection virulence
[DOI] 10.1038/s41585-021-00477-x PMC 바로가기 [Article Type] Review

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

인간에서 BNT162b2 mRNA 백신의 시스템 백신학

Observational Study

Published on 2021-08-012022-09-11
Journal: Nature [Category] Fulltext, MERS, 변종, 비임상, 유전자 메커니즘, 임상, 진단,

[키워드] Adaptive immune response Analysis Antigen AP-1 approach B.1.351 B.1.351 variant BNT162b2 BNT162b2 mRNA vaccine booster booster vaccination CD14 CD16 CD4 CD8 T cell CD8 T cells Cluster Concentration demonstrated elicit Emergency use authorization evidenced Frequency greater healthy volunteer Human immune response immune responses immune system immunization increase in Inflammatory inflammatory monocytes innate antiviral immunity innate immune response innate immune system interferon landmark less monocyte Monocytes mRNA vaccination mRNA vaccine mRNA vaccines myeloid cell Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses pathway Pfizer-BioNTech mRNA vaccine plasma protective immune response reduced robust SARS-CoV-2 second dose secondary immunization significant increases in single-cell stimulate stimulated System T cell T cells These data transcription factor transcription factors transcriptional transcriptomics vaccination wild-type SARS-CoV-2
[DOI] 10.1038/s41586-021-03791-x PMC 바로가기 [Article Type] Observational Study

Vitamin D, infections and immunity

비타민 D, 감염 및 면역

Review

Published on 2021-07-292022-09-10
Journal: Reviews in Endocrine & Metabolic Disorders [Category] 유전자 메커니즘,

[키워드] β-defensin 2 25-hydroxyvitamin D accelerate Analysis Antibacterial antimicrobial peptide antimicrobial peptides Antiviral antiviral responses arising autophagy benefit best CAMP caries cascades Cathelicidin characterized condition COVID-19 COVID-19 crisis COVID-19 pandemic Critical CYP27B1 deficiency Dental caries disease severity Diseases downstream dysregulation epidemiological Evidence expression expression of gene greater handling Health identify Immune cell immune cells immune responses Immunity in some induce Infection Infectious diseases Inflammation Inflammatory bowel disease inflammatory bowel diseases innate immune innate immune response innate immune responses innate immune system intestinal flora intracellular pathogens knowledge Laboratory Local macrophages mechanism microbial Mortality NOD2 pathogen Pathogens Pattern recognition Pattern recognition receptors peptide peptides Poor promote provide reduce respiratory respiratory tract severity Signaling signaling cascade signaling cascades skeletal stimulate Strong susceptibility therapeutic intervention therapeutic interventions therapeutic potential Tuberculosis turn upstream Vaccines Viral viral infections Vitamin D vitamin D deficiency Vitamin D status Vitamin D supplementation
[DOI] 10.1007/s11154-021-09679-5 PMC 바로가기 [Article Type] Review

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Public Health

Published on 2021-07-282022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

[키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened
[DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health

SARS-CoV-2 Infection and Racial Disparities in Children: Protective Mechanisms and Severe Complications Related to MIS-C

Article

Published on 2021-07-132022-10-30
Journal: Journal of racial and ethnic health disparities [Category] COVID-19, SARS,

[키워드] ACE-2 Adults affected assist black Care children clinical feature Community Complication confirmed case current cytokine response deaths disparity distribution Follow-up function groups Health Health disparities help Hispanic homeostatic identify immune mechanism Immunity indicated Infection Inflammation Inflammatory innate immune system Kawasaki disease less maintain MIS-C MOST Novel coronavirus pandemic Patient pediatrics Population professional Protective protective mechanisms Racial recorded reduce SARS-CoV-2 SARS-COV-2 infection severe complications severe disease Spread susceptible Symptom syndrome USA Vaccinations Vaccine was performed
[DOI] 10.1007/s40615-021-01092-7 PMC 바로가기 [Article Type] Article

High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion

COVID-19의 고해상도 혈청 프로테옴 궤적은 환자별 혈청 전환을 나타냅니다

Article

Published on 2021-07-072022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Analysis antibody apoA1 APOC1 APOC2 APOC3 APOH applied association biobanking Biological functions biological processes Biomarker Biomarkers CD14 changed clinical chemistry clinical chemistry parameters Coagulation Coagulation system commonality Control controls correlation Course COVID‐19 COVID‐19 patient COVID‐19 patients CRP FIVE FN1 foundation functional group Hospitalized HRG immunoassay Immunoglobulin immunoglobulins individual‐specific innate immune innate immune system KNG1 LBP LGALS3BP lipid homeostasis longitudinal samples mass spectrometry Microbiology, Virology & Host Pathogen Interaction molecular pathophysiological pathophysiology patients PLG PON1 Protein Proteins proteome proteomics provide quantified Region regions Regulation regulator Saa1 SARS‐CoV‐2 SARS‐CoV‐2 Seroconversion serum serum sample significantly symptomatic the disease therapeutic targets trajectory were measured
[DOI] 10.15252/emmm.202114167 PMC 바로가기 [Article Type] Article