Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2′- O -methyl transfer by SARS-CoV-2 nsp16MN 2+ SARS-COV-2 NSP16에 의한 효율적인 2'-O- 메틸 전달에 대한 기질을 정렬하는 CAP-0-RNA를 좌표Research Article Published on 2021-06-292022-09-10 Journal: Science Signaling [Category] MERS, SARS, 치료기술, [키워드] absence active site adenosylmethionine aligning Alter backbone binding biochemical capping catalysis coactivator complex conserved Coordinate coronavirus Coronaviruses Degradation Donor drug design efficient ENCODE enzyme Final generate heterodimeric Host host cell host defenses inhibitors innate response insert Interaction mammalian Messenger RNA metal ion metal ions methyl group methyltransferase mRNA nsp10 organism Prevent PROTECT resulting ribonucleotide ribonucleotides RNA RNAs SAM SARS-CoV-2 SARS-CoV-2 genome selective structural evidence Structure structures substrate substrates the SARS-CoV-2 transfer translation triggering unique Viral viral RNAs virus replication X-ray structure [DOI] 10.1126/scisignal.abh2071 PMC 바로가기 [Article Type] Research Article
Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor ShiftlessArticle Published on 2021-06-252022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis binding binding activity codon coronavirus decrease downregulation Efficiency expressed Factor frameshift Human immunodeficiency virus IBV in vitro interferon-stimulated gene mammalian Murine leukemia virus Protein purified readthrough reduced Replication restrict restriction ribosome RNA RNA structures SARS-CoV SARS-CoV-2 SHFL Shiftless specificity stimulatory STOP variety virus [DOI] 10.3390/v13071230 PMC 바로가기 [Article Type] Article
Drosophila , a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2Review Published on 2021-06-132022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] Drosophila animal model animal models complementary conserved coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine current Drosophila Drug testing drugs Effect effective ethical concern functional functions Genetic Host host tissue human diseases humans interactions intrinsic limitation lack limitation mammalian mammals Mutant SARS-CoV-2 offer organ Outbreaks pathogenicity Pathways pharmacological physiological platform Primary determinants of pathogenicity progeny Protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 research strain the SARS-CoV-2 tissues virus Virus-host interaction Virus-host interactions was used whole organism [DOI] 10.1186/s13578-021-00621-5 PMC 바로가기 [Article Type] Review
Zoonotic and Reverse Zoonotic Transmissibility of SARS-CoV-2Review Published on 2021-06-092022-10-04 Journal: Virus research [Category] MERS, SARS, 조류인플루엔자, 치료기술, [키워드] acute respiratory syndrome appear caused causes coronavirus COVID-19 COVID-19 disease COVID-19 pandemic disease effort Epidemiology genomic change Human infecting inquiry intermediate host knowledge mammalian MONITOR pandemic panzootic Prevent provide Re-infection recent repeated risk robust SARS-CoV-2 Spread Support the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 Transmission virus zoonoses zoonotic [DOI] 10.1016/j.virusres.2021.198473 PMC 바로가기 [Article Type] Review
Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNAResearch Article Published on 2021-06-012022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS, [키워드] accounted adaptive aligned ANOVA antiretroviral APOBEC association Caliciviridae change coding region Combination component contribute Coronaviridae dataset disease driven by Evidence Evolution Extensive fixation Flaviviridae Frequency Generation time genetic change Genome genome sequence genomes genomic HCV HIV-1 homoplasy identity infecting investigated mammalian mammals mechanism mechanisms multivariable analysis Mutation mutations Neutral Occurrence parameter phylogenetically provide random replicate Replication reported representing retrovirus RNA RNA secondary structure RNA virus RNA viruses SARS Coronavirus SARS-CoV-2 sequence sequence variability significantly subset Substitution thought transcriptional upstream Viral RNA virus while [DOI] 10.1371/journal.ppat.1009596 PMC 바로가기 [Article Type] Research Article
Diagnostic Potential of a Luminex-Based Coronavirus Disease 2019 Suspension Immunoassay (COVID-19 SIA) for the Detection of Antibodies against SARS-CoV-2SARS-CoV-2에 대한 항체 검출을 위한 Luminex 기반 코로나바이러스 질병 2019 Suspension Immunoassay(COVID-19 SIA)의 진단 가능성Article Published on 2021-05-262022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid amino acids antibody Antibody test Antigen antigens assays best blood donor Blood donors Cell Concentration convalescent coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cross-react detectable detection Diagnostic method enzyme enzyme immunoassay evaluated expressed False positive IgG IgM IgM and IgG immunoassay individual Infants insect cells mammalian negative control other coronaviruses pandemic Patient PCR positive sample Potential Protein Quantitative rapid antibody test respiratory S protein SARS-CoV-2 sensitivity Serologically serology serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 specificity suggested Suspension Swedish virus infection was selected with COVID-19 [DOI] 10.3390/v13060993 PMC 바로가기 [Article Type] Article
A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders면역 매개 장애가 있는 개인의 글리칸 알파-갈에 대한 항체 반응 분석을 위한 데이터세트Data Note Published on 2021-05-252022-09-12 Journal: F1000Research [Category] MERS, SARS, 진단, [키워드] age and sex allergic reaction allergies allergy alpha Gal alpha-Gal syndrome Analysis antibody Antibody Response Blood Group Clinical characteristics coronavirus COVID-19 dataset develop diagnosed disease disorder Factor Guillain-Barré syndrome Human IgE immune response Immune-mediated in healthy individual individual mammalian Membrane proteins Modification pathogen Patient patients with COVID-19 protective mechanisms syndrome tick [DOI] 10.12688/f1000research.27495.2 PMC 바로가기 [Article Type] Data Note
Functional-genomic analysis reveals intraspecies diversification of antiviral receptor transporter proteins in Xenopus laevis기능 게놈 분석은 Xenopus laevis에서 항바이러스 수용체 수송체 단백질의 종 내 다양화를 보여줍니다Research Article Published on 2021-05-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African African clawed frog Analysis Antiviral assays clade described effector Evolution expression family functional G-protein homolog identify immune immune stimulation independent Infection inhibit Innate immunity involved knowledge less mammal Mammalia mammalian mammals MOST Olfaction olfactory physiological Positive selection Protein receptor regulate reveal RNA sequencing RNA viruses Signaling transporter upregulated vertebrates Viral viral infection Xenopus [DOI] 10.1371/journal.pgen.1009578 PMC 바로가기 [Article Type] Research Article
Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenzaArticle Published on 2021-05-202022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 신종인플루엔자, 치료기술, 치료법, [키워드] Co-infection Combined COVID-19 COVID-19 pathogenesis demonstrated disease effective ferret ferrets flu vaccine H1N1 hACE2 Host immune responses immunization indicated Infection Infectious diseases Influenza influenza A K18 lung mammalian mice Mortality Neutralizing antibody titer no significant difference outcome PiCoVacc Pneumonia prevention of COVID-19 pulmonary damage reduced Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine the SARS-CoV-2 virus throat swab vaccination Viral load viral shedding virus was increased was performed [DOI] 10.1038/s41392-021-00618-z PMC 바로가기 [Article Type] Article
mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA virusesReview Published on 2021-05-162022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome coronavirus coronavirus disease COVID-19 demonstrated Efficacy Evidence Frequently highlight in viral Infection infections inhibiting mammalian modulated modulation mTOR mTOR inhibitor mTORi pathway Rapamycin recent Replication RNA virus RNA viruses SARS-CoV-2 Support Treatment virus growth [DOI] 10.1002/jmv.26728 PMC 바로가기 [Article Type] Review