Necrosis – Page 8 – Communicable Diseases Research

The role of tumor necrosis factor alpha − 308A > G polymorphism on the clinical states of SARS-CoV-2 infection

Research

Published on 2022-03-072022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,

[키워드] 95% CI A allele acute respiratory syndrome Affect allele Alpha Asymptomatic coronavirus Coronavirus infections country COVID-19 COVID-19 patients cytokine Defense described determine expression form G allele Genotype Host include increase individual mechanism Mild Mutation Necrosis pathogenesis of COVID-19 patients polymorphism Polymorphisms presenting promoter region Result risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 single-nucleotide subject Symptom symptomatic Symptomatic patients symptoms of COVID-19 the disease TNFα transcriptional activity tumor necrosis tumor necrosis factor alpha was used
[DOI] 10.1186/s43042-022-00274-0 PMC 바로가기 [Article Type] Research

Clinicopathologic characteristics of severe COVID-19 patients in Mexico City: A post-mortem analysis using a minimally invasive autopsy approach

Research Article

Published on 2022-03-032022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

[키워드] alteration Analysis approach Autopsies Autopsy Characteristics characterized Clinical finding cohort study cohorts correlation COVID-19 Deceased demonstrated described diagnosis of SARS-CoV-2 diagnostic Diffuse alveolar damage Endothelitis feature hallmark hepatic histologic histological histology Histopathology Inflammation Injury Interstitial nephritis invasive kidney Liver function Liver histology liver tissue lung Lung compliance mechanical ventilation Mexico City Necrosis neutrophilic objective Patient performed Pneumonia Post-mortem predominant reported Result SARS-CoV-2 positivity setting severe COVID-19 patient severe SARS-CoV-2 steatosis the disease thrombosis
[DOI] 10.1371/journal.pone.0262783 PMC 바로가기 [Article Type] Research Article

Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury

급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘

Article

Published on 2022-03-012022-08-31
Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제,

[키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting
[DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article

A four-month follow-up study of Cardiac performance in patients hospitalized with COVID-19 in a Tertiary Care Government Medical Hospital

Conference abstract

Published on 2022-03-012022-10-05
Journal: International Journal of Infectious Diseases [Category] 바이오마커,

[키워드] abnormality acute COVID-19 acute phase age alteration Analysis analyzed average Biomarker Cardiac abnormality cardiac disease cardiac function Cardiac performance cardiac troponin cardiovascular risk cardiovascular risk factor change clinical symptom conducted contrary coronavirus disease COVID-19 COVID-19 hospitalization COVID-19 illness COVID-19 infection diabetes diastolic dysfunction Dyspnea echocardiographic Elevation Factor follow-up study hypertension Infection information Injury laboratory-confirmed male manifestation marker material Myocardial infarction myocardial injury myocarditis Necrosis Patient patients hospitalized Pneumonia pulmonary artery pressure questionnaire reported Result sensitivity analysis significant increase statistically significant symptomatic Tertiary the SARS-CoV-2 ventricular with COVID-19
[DOI] 10.1016/j.ijid.2021.12.135 [Article Type] Conference abstract

Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19

SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할

Review

Published on 2022-03-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료법,

[키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor
[DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review

Acute SARS-CoV-2 alpha variant infection leading to placental insufficiency and fetal distress

태반 기능 부전 및 태아 고통을 유발하는 급성 SARS-CoV-2 알파 변이체 감염

Case Reports

Published on 2022-03-012022-09-11
Journal: Journal of medical virology [Category] SARS, 변종,

[키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age Alpha Alpha variant B.1.1.7 B.1.1.7 lineage Brain Care Cesarean section coronavirus demonstrated distress fetal fetal distress fetal movement FIBRIN gestational age high viral load hospital induce Infection intensive care Ischemic necrosis Maternal Health Medical care Necrosis Neonatal neonatal intensive care unit Neonate Obstetric obstetric infection obstetrics oligohydramnios pathological Pathological examination pathology Placenta placental placental insufficiency placental tissue placentitis positive Pregnancy reduced reduced fetal movement SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 infected patients seeking severe acute respiratory syndrome Coronavirus subsequent tested the SARS-CoV-2 umbilical umbilical artery variant Viral load VOC 202012/01 was performed
[DOI] 10.1002/jmv.27379 PMC 바로가기 [Article Type] Case Reports

Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study

COVID-19로 입원한 환자의 낮은 생존율에 대한 위험 요인으로 입원 시 낮은 비타민 D 상태: 이탈리아 후향적 연구

Article

Published on 2022-03-012022-09-11
Journal: Journal of the American Nutrition Association [Category] MERS, SARS, 바이오마커,

[키워드] 25-hydroxyvitamin D 95% confidence interval Admission Alpha Analysis association available data best Biomarker blood cell C-reactive protein characteristic Clinical course Coagulation Cohort conducted consecutive patient count COVID-19 cytokine Cytokine storm D-dimer different time point evaluate exhibited Factor ferritin fibrinogen High-sensitivity C-reactive protein hospital Hospital mortality Hospitalization hospitalized patient hospitalized patients hsCRP hypovitaminosis Hypovitaminosis D IL-6 in-hospital mortality incidence independent risk factor Inflammation Inflammatory inflammatory markers institution interleukin interleukin 6 Italian logistic regression model lymphocyte marker median Mortality Multivariate analysis Necrosis neutrophil NLR non-survivor Non-survivors Odds ratio Patient PCT performed Poor poor prognosis Predictive preliminary findings Prevalence procalcitonin receiver operating characteristic Retrospective study risk SARS-CoV-2 SARS-COV-2 infection Sepsis serum serum 25-hydroxyvitamin D severity of COVID-19 significantly significantly higher status subsequent survivor the disease TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha two groups Vitamin Vitamin D Vitamin D status WBC WBC count White blood cell with COVID-19
[DOI] 10.1080/07315724.2021.1877580 PMC 바로가기 [Article Type] Article

Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection

SARS-CoV-2 감염에 대한 아유르베다 전통 약용 식물의 항바이러스 활성

Article

Published on 2022-03-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제,

[키워드] ACE2 ACE2 receptor amarogentin Analysis angiotensin Antiviral antiviral activity antiviral role apoptotic pathway approach attachment inhibitor Ayurveda belladonnine COVID-19 criteria demonstrated disease drug design drug-likeness drug-target interaction Drug-target interactions Efficacy etiological agent G-protein gene network gene network analysis highest affinity Host membrane protein MOST Necrosis network analysis nuclear parameter pathway Pathways pharmacokinetic pharmacokinetics Phosphorylation plant positive potential therapy predicted Protein protein kinase Protein kinase B receptor Regulation responsible SARS-CoV-2 SARS-COV-2 infection secretion Serine Signaling spike glycoprotein Structure-based drug design suggested target target prediction. Toxicity Transport Tumor tumor necrosis tumor necrosis factor Vaccine was performed
[DOI] 10.1080/07391102.2020.1832577 PMC 바로가기 [Article Type] Article

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

입원한 COVID-19 환자의 표준 치료와 비교한 나밀루맙 또는 인플릭시맙(CATALYST): 무작위, 다기관, 다군, 다단계, 공개 라벨, 적응형, 2상, 개념 증명 시험

Clinical Trial

Published on 2022-03-012022-09-12
Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단,

[키워드] 95% CI adaptive adverse event analysed assigned Bayesian C-reactive protein (CRP Care colony stimulating factor Complete Concentration COVID-19 CRP Efficacy enrolled Evidence FIVE greater hospital hospitalised patient Inflammation inhibitor intensive care Interaction Intervention intravenous dose investigator ISRCTN Medical Research Council multi-arm multicentre Necrosis nine occurred Open-label outcome parallel-group participant Patient Phase 3 trials Pneumonia point estimate primary endpoint Primary outcome Probability randomised Randomly recruited reducing reduction in Registered screened Standard of care stratified treatment allocation Trial usual care usual care alone usual care group with COVID-19
[DOI] 10.1016/S2213-2600(21)00460-4 PMC 바로가기 [Article Type] Clinical Trial

Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection leading to extensive skin necrosis

Research article

Published on 2022-03-012022-10-05
Journal: Clinics in dermatology [Category] COVID19(2023년), SARS, 변종,