High Levels of Neutrophil Extracellular Traps Persist in the Lower Respiratory Tract of Critically Ill Patients With Coronavirus Disease 2019코로나바이러스 질병 2019를 앓고 있는 중환자의 하기도에서 높은 수준의 호중구 세포외 트랩이 지속됨Article Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Admission alveolar alveolar spaces ARDS baseline Blood chemokine chemokines contribute coronavirus correlated Course COVID-19 Critically ill Critically ill patient critically ill patients Deceased deteriorate disease disease severity Extracellular Ill implicated Inflammatory marker inflammatory markers intensive care intensive care unit admission investigated Level Lower Lower respiratory tract LRT lung tissue marker NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Pathogenesis patient with COVID-19 peaked plasma plasma samples produced respiratory respiratory distress Respiratory distress syndrome respiratory tract retained RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sputum syndrome the SARS-CoV-2 thrombosis tract with COVID-19 [DOI] 10.1093/infdis/jiab050 PMC 바로가기 [Article Type] Article
Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019호중구는 코로나바이러스 질병 2019에서 폐를 손상시키기 위해 세포외 트랩을 설정합니다Editorial Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar ARDS Blood chemokine chemokines contribute correlated Course COVID-19 COVID-19 patients critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients deteriorate disease disease severity fatal COVID-19 ICU admission implicated Inflammatory marker inflammatory markers investigated Lower respiratory tract LRT lung tissue marker NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Pathogenesis pathology patients peaked plasma produced respiratory distress retained SARS-CoV-2 SARS-CoV-2 RNA sputum syndrome thrombosis [DOI] 10.1093/infdis/jiab053 PMC 바로가기 [Article Type] Editorial
The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19Review Published on 2021-05-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activate aggregation cell damage chemokine circulation contributing to COVID-19 COVID-19 patients Endothelitis highlighting IL-8 immunothrombosis Infection Innate immunity killing mechanism mechanisms morbidity and mortality NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils Pathogenesis pathogenesis of COVID-19 Pathogens Platelet previous study promote prothrombotic regulated Research role SARS CoV-2 shown Thromboinflammation Thrombotic complications White blood cell [DOI] 10.3390/ijms22105368 PMC 바로가기 [Article Type] Review
Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation결함 있는 NET 제거는 COVID-19 관련 폐 혈전 염증에서 지속적인 FXII 활성화에 기여합니다Research paper Published on 2021-05-142022-09-11 Journal: EBioMedicine [Category] 유전자 메커니즘, [키워드] accumulation Activation activity alveolar alveolar spaces Analysis clearance clinical Coagulation coagulation factor Coagulopathy Contact contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNase Donor European expression Extracellular factor XII FIBRIN finding foundation funding FXII hallmark hallmarks Hamburg healthy control immunostaining in vitro increased mortality Inflammation leads lung lung parenchyma lung tissue mechanism NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps offer pathogenic Pathologies Patient performed plasma sample plasma samples procoagulant Proinflammatory response proteomic Proteomic analysis Pulmonary thrombo-inflammation reduced Support supported sustained targeting therapeutic strategy thrombosis union vasculature was increased [DOI] 10.1016/j.ebiom.2021.103382 PMC 바로가기 [Article Type] Research paper
Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular TrapsCOVID-19의 면역혈전증: 호중구 세포외 트랩의 의미Review Published on 2021-05-062022-09-01 Journal: Biomolecules [Category] SARS, 바이오마커, 진단, [키워드] Activation activation pathway acute phase reactant acute phase reactants analyzed Bacterial causative agent Cell CID clinical manifestation clinical manifestations Coagulation coronavirus COVID-19 COVID-19 pandemic CRP D-dimer Disseminated intravascular coagulation DNA elevated etiological Extracellular family fungal hospitalized patient hospitalized patients immunothrombosis include increased risk infection control Inflammatory mediators innate immune response Interaction interleukin intravascular coagulation involved Kidney disease Lactate lactate dehydrogenase leads marker mechanism member Mortality MPO NET NETs neutrophil Neutrophil extracellular traps Neutrophils outbreak patients with COVID-19 Previous studies previous study Recognition recruit respiratory Respiratory disease respiratory diseases SARS-CoV-2 severe COVID-19 severe disease shown thrombotic thrombotic event Thrombotic events total neutrophil count Vascular Viral with COVID-19 [DOI] 10.3390/biom11050694 PMC 바로가기 [Article Type] Review
Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration Research Published on 2021-05-032022-10-05 Journal: Nature cancer [Category] 진단, [키워드] body mass index Breast cancer cancer cell cancer-related deaths Cytometry elevated endothelial extracellular DNA Genetic imaging impairment induce inhibitor junctions lung mechanism Metastasis mice NET NETs neutrophil obese obese adipose tissue obesity oxidative stress Patients with cancer peripheral circulation preclinical study progression reactive oxygen specy reversed shown Treatment tumor cell underlie Vascular vascular dysfunction [DOI] 10.1038/s43018-021-00194-9 [Article Type] Research
Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markersCOVID-19에 걸린 어린이의 혈액 호중구는 염증 및 항염증 마커를 모두 나타냅니다Observational Study Published on 2021-05-012022-08-31 Journal: EBioMedicine [Category] SARS, 바이오마커, 임상, 진단, [키워드] Activation acute lung injury Adhesion Molecule adhesion molecules Adults analyzed Anti-inflammatory Asymptomatic Blood Blood samples Buenos Aire Buenos Aires CD11b CD64 CD66b Cell-adhesion molecules cell-free DNA children children with COVID-19 circulating neutrophil circulating neutrophils Concentration COVID-19 cytokine cytokine production Cytokines DNA ELISA expression Fcγ receptor flow cytometry fluorometry healthy children healthy controls HLA-DR IgG IgG antibodies IgG antibody immune response infiltration Inflammatory inhibitory receptor Inhibitory Receptors L-selectin low expression lower expression Lung function Lung injury marker Mild MIS-C Moderate COVID-19 NET NETs neutrophil Neutrophils no differences observational study PD-L1 pediatric pediatric COVID-19 phenotype plasma Plasma levels Prevent promotion quantified receptor respiratory respiratory symptoms SARS-CoV-2 Science serum severe COVID-19 severe respiratory symptom severe respiratory symptoms Spike protein supported syndrome technology the spike protein tissue university was performed were measured [DOI] 10.1016/j.ebiom.2021.103357 PMC 바로가기 [Article Type] Observational Study
Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2SARS-CoV-2에 감염된 골든 시리아 햄스터의 폐에 있는 혈관염 및 호중구 세포외 트랩Immunology Published on 2021-04-122022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] alterations animal model animal models Antigen cause characterized contribute correlation COVID-19 COVID-19 pathogenesis COVID-19 patients days post infection disease edema endothelial damage extracellular trap FIBRIN hamster Human humans hyperplasia Infection infiltration Inflammation interstitial inflammation interstitial pneumonia lesion lung Lungs Macrophage macrophages NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils neutrophils extracellular traps (NETs) Pathogenesis pulmonary pulmonary lesion pulmonary lesions resolved SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity shown These data Trigger Type II pneumocyte type II pneumocyte hyperplasia Vascular vascular lesion vascular lesions Vasculitis vessel virus [DOI] 10.3389/fimmu.2021.640842 PMC 바로가기 [Article Type] Immunology
Association of Neutrophil Activation, More Than Platelet Activation, With Thrombotic Complications in Coronavirus Disease 20192019년 코로나바이러스 질병의 혈전 합병증과 함께 혈소판 활성화 이상의 호중구 활성화 연관성Article Published on 2021-03-292022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] activated activating acute respiratory syndrome age analyzed Antithrombotic Aspirin association Biomarker Biomarkers blocked Complication coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 disease severity enzyme feature healthy control help heparin hospitalized patients hypercoagulability Infection inhibiting less leukocyte leukocyte activation leukocytes low-molecular weight heparin matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil extracellular traps (NETs) Neutrophils normalized Patient patients with COVID-19 plasma Platelet platelet activation Platelets predict respiratory SARS-CoV-2 Severe acute respiratory syndrome significantly increased thrombosis Treatment triggered Venous Thromboembolism venous thromboembolism (VTE) VTE were measured worsening [DOI] 10.1093/infdis/jiaa756 PMC 바로가기 [Article Type] Article
Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19Research Article Published on 2021-03-242022-10-28 Journal: ACS Central Science [Category] COVID-19, [키워드] activate agonist cascade caused cell death characterized complications coronavirus disease COVID-19 cytokine death Deleterious hyperinflammation Hyperinflammatory hyperinflammatory responses immune response induce Infection infection with SARS-CoV-2 Inflammation inhibit key factor limit molecular pattern NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap neutrophilic pathway Patient plasma Production proinflammatory receptor severe COVID-19 Signaling suggested suppress synthetic therapeutic therapeutic strategy tissue damage TLRs Toll-like receptor viral pathogen viral-induced with COVID-19 [DOI] 10.1021/acscentsci.0c01669 PMC 바로가기 [Article Type] Research Article