no effect – Page 8 – Communicable Diseases Research

COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics—a review

COVID-19: 분자 병태생리학, 유전적 진화 및 전향적 치료법—검토

Review

Published on 2021-02-082022-08-31
Journal: Archives of Microbiology [Category] 신약개발, 치료제,

Remdesivir for Adults With COVID-19 : A Living Systematic Review for American College of Physicians Practice Points

COVID-19가 있는 성인을 위한 렘데시비르: 미국 의사 학회(American College of Physicians) 실습 포인트에 대한 살아있는 체계적인 검토

Article

Published on 2021-02-012022-09-11
Journal: Annals of internal medicine [Category] Fulltext, SARS, 임상, 치료제,

[키워드] age ARD assessment assessments benefit certainty Clinical improvement college coronavirus disease Coronavirus disease 2019 Course COVID-19 Department development disease severity drug Effectiveness evaluate Evidence excluded extracorporeal membrane oxygenation food health administration hospital Hospitalized hospitalized patient hospitalized patients IMPROVE kidney kidney or liver disease Liver disease mechanical ventilation moderate New no effect office Open-label open-label trials physician Placebo Point Practice pregnant women preliminary report Program randomized trial receiving reduce reduce mortality reduction in mortality Remdesivir research and development review risk risk difference searched Serious Adverse Event Serious Adverse Events service severe COVID-19 Sex symptom duration synthesis Time to recovery Treatment trials U.S. Food and Drug Administration veteran website with COVID-19
[DOI] 10.7326/M20-5752 PMC 바로가기 [Article Type] Article

Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?

폭풍과의 싸움: 새로운 항-TNFα 및 항-IL-6 C. sativa 품종이 COVID-19의 사이토카인 폭풍을 길들일 수 있습니까?

Research Paper

Published on 2021-01-312022-08-31
Journal: Aging (Albany NY) [Category] 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome addition aging anti-IL-6 anti-inflammatory effect Anti-inflammatory effects anti-inflammatory regimen approach ARDS autoinflammatory disease Cancer cannabis cascade CCL2 cell line complications conditions COVID-19 COVID-19 cytokine storm COVID-19 disease COVID-19 patient COVID-19 patients COX2 cytokine Cytokine storm Cytokines death Deleterious disease disease severity down-regulation downregulate effective Escalation expression fibroblast fibrosis Fighting frailty Gene Expression had no IL-6 include induce Inflammation Inflammatory Inflammatory cytokine Initially involved lead leads lung Lung fibrosis medical cannabis modulate molecular MOST no effect novel Pathogenesis pathway Pathways Prevent pro-inflammatory cytokine pro-inflammatory cytokines proinflammatory cytokines respiratory distress responsible rheumatological SARS-CoV2 Seven severe COVID-19 disease syndrome target tested therapeutic These data tissue tissues TNFα TNFα treat treated Treatment
[DOI] 10.18632/aging.202500 PMC 바로가기 [Article Type] Research Paper

Summary of the Available Molecular Methods for Detection of SARS-CoV-2 during the Ongoing Pandemic

진행중인 유행성 전염병 동안 SARS-CoV-2의 검출에 사용 가능한 분자 방법의 요약

Review

Published on 2021-01-282022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, 변종, 진단, 치료기술, 치료제,

[키워드] 501Y.V2 501Y.V2 variant affected B.1.1.7 variant caused Containment containment strategies Coronaviridae COVID-19 COVID-19 pandemic described detection Diagnosis diagnostic diagnostic protocol Evolution excess genetic variability genomic gold gold standard in silico analysis Laboratory laboratory diagnosis molecular molecular methods morbidity morbidity and mortality mortality rates Mutation no effect pandemic probes protocol protocols Region reliability respiratory respiratory sample Respiratory samples SARS-CoV-2 SARS-CoV-2 genome sensitivity situation South Africa target UK variant variants Viral viral genome virus virus variant
[DOI] 10.3390/ijms22031298 PMC 바로가기 [Article Type] Review

Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19

SARS-CoV-2 수용체 ACE2 활성 수준은 대동맥 협착증이 있는 고령 환자에서 매우 높아집니다. COVID-19의 중증도에 대한 바이오마커로서의 ACE2의 의미

Original Article

Published on 2021-01-202022-09-11
Journal: GeroScience [Category] MERS, 바이오마커,

[키워드] ACE2 ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Aortic stenosis Biomarker blood pressure cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular diseases cellular receptor chronic inflammation circulating Clinical data coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlated COVID-19 COVID-19 mortality COVID-19 susceptibility CRP drug Ejection fraction elderly Elderly patient elderly patients elevated flow velocity functions GFR healthy individual healthy individuals high mortality higher risk hypertension hypertensive implication independent independent of inflammatory state inhibitor inhibitory Kidney function left ventricular ejection fraction Level no effect Older Patient patients RAAS receptor ACE2 respiratory SARS-CoV-2 SARS-CoV-2 susceptibility serum severe acute respiratory syndrome Coronavirus severity of COVID-19 Support systolic pressure TAPSE the SARS-CoV-2 ventricular ventricular ejection were measured
[DOI] 10.1007/s11357-020-00300-2 PMC 바로가기 [Article Type] Original Article

A Treatment to Eliminate SARS-CoV-2 Replication in Human Airway Epithelial Cells Is Safe for Inhalation as an Aerosol in Healthy Human Subjects

인간 기도 상피 세포에서 SARS-CoV-2 복제를 제거하는 치료법은 건강한 인간 대상에서 에어로졸로 흡입하기에 안전합니다

Article

Published on 2021-01-012022-08-31
Journal: Respiratory care [Category] SARS, 유전자 메커니즘, 치료법, 치료제,

[키워드] Activation aerosol airway Airway inflammation airway pH. Cell cells clinical trial Concentration COVID-19 Defense determine Diseases endosomal trafficking expression had no healthy subjects Host host defense Human human airway epithelial humans impair in vivo Infection inhalation Inhaled inhibited isotonicity Lung function mechanisms multiplicity multiplicity of infection N protein no effect nucleocapsid osmolality Oxygenation Patient patient safety phase Placebo Plaque assay Prevent prevented protein levels raise raised Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral replication subject subjects Treatment Trial USA-WA1/2020 viability Viral viral infection viral replication vital signs was determined
[DOI] 10.4187/respcare.08425 PMC 바로가기 [Article Type] Article

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis

코로나19 환자에 대한 클로로퀸 또는 하이드록시클로로퀸의 효능: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-01-012022-09-11
Journal: Journal of Antimicrobial Chemotherapy [Category] 임상, 치료제,

[키워드] 95% CI adjusted Admission Azithromycin Chloroquine clinical Clinical studies clinical trials Cohort studies cohort study Combination COVID-19 COVID-19 disease COVID-19 patients demonstrated Efficacy estimate evaluate the effect Evidence examined Grey literature had no HCQ Hospitalization hospitalized patient Hydroxychloroquine ICU lack mechanical ventilation Meta-analysis Mortality no effect no significant effect outcome Outpatient outpatients patients patients hospitalized randomized clinical trial RCT RCTs reducing reported risk searched Seven significant effect systematic review Ventilation Viral viral clearance with COVID-19
[DOI] 10.1093/jac/dkaa403 PMC 바로가기 [Article Type] Meta-Analysis

Patient Flow Dynamics in Hospital Systems During Times of COVID-19: Cox Proportional Hazard Regression Analysis

Public Health

Published on 2020-12-082022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS,

Early hydroxychloroquine but not chloroquine use reduces ICU admission in COVID-19 patients

초기 하이드록시클로로퀸(클로로퀸은 사용하지 않음)은 COVID-19 환자의 ICU 입원을 감소시킵니다.

Article

Published on 2020-12-012022-09-11
Journal: International Journal of Infectious Diseases [Category] SARS, 치료제,

[키워드] 28-day mortality 95% CI all-cause mortality Analysis Azithromycin Chloroquine clinical Clinical course competing controls COVID COVID-19 COVID-19 patient death drugs Effect groups hazard ratio HCQ hospitalized patient hospitalized patients Hydroxychloroquine ICU ICU admission intensive care intensive care unit investigated lack Mortality Netherlands no effect no significant effect non-ICU Observational cohort study observational study outcome Patient Primary outcome Primary outcomes Prospective Study recent reduce reduction in regression analysis remained reported risk significantly Toxicity transfer Treatment use of hydroxychloroquine was performed were given
[DOI] 10.1016/j.ijid.2020.09.1460 PMC 바로가기 [Article Type] Article

Is there any potential management against COVID-19? A systematic review and meta-analysis

COVID-19에 대한 잠재적인 관리가 있습니까? 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2020-12-012022-09-11
Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] 치료제,

[키워드] 95% CI 95% confidence interval Anakinra antiviral therapy article articles calculate Clinical effect Clinical improvement Clinical management convalescent plasma Convalescent plasma therapy COVID-19 COVID-19 infection COVID-19 pandemic Critical database declined Effect Efficacy eligibility criteria estimation Frequency had no Hydroxychloroquine ICU identify immunomodulator immunomodulators Immunomodulatory agent Immunomodulatory agents Improvements inception infected patients intensive care intensive care unit Intervention management mechanical ventilation medication medications Meta-analysis Mortality mortality rate Negative conversion no effect outcome outcomes Patient plasma plasma therapy Quantitative analysis random-effects model reduce Relative risk risk SARS-CoV-2 Scholar searched shown significantly standard treatment suggested systematic review therapy Tocilizumab Treatment was performed
[DOI] 10.1007/s40199-020-00367-4 PMC 바로가기 [Article Type] Meta-Analysis