Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다Research Article Published on 2016-09-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast [DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L ActivationResearch Article Published on 2016-03-292022-10-29 Journal: mBio [Category] Coronavirus, [키워드] accessory protein activate Activation acute respiratory syndrome antiviral activity Betacoronavirus calu-3 cells cell death characterized cleave contribute coronavirus Coronaviruses CoV Critical cytoplasmic dsRNA enzyme expressed expression level genes encoding Genome highly pathogenic homolog Host host antiviral response host innate immunity IFN IFN signaling in vivo model inactivation Infection Innate immunity interferon involved Like Lineage mechanism MERS MERS-CoV MERS-CoV infection Middle East murine mutant NLS NS2 NS4b nuclear localization signal nucleus offer other coronaviruses Pathogenesis pathway potential mechanism Prevent Protein provide Replication reported required respiratory respiratory syndrome coronavirus RNA RNase SARS-CoV single-stranded Spread ssRNA subsequent therapeutic intervention translational type I interferon viral double-stranded RNA viral pathogenesis viral replication virulence [DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
The Nucleocapsid Protein of Human Coronavirus NL63Research Article Published on 2015-02-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis binding C-terminal domain Cell cell cycle progression cellular processes Characteristics Coronaviral coronavirus described disease expressing feature Genetic genomes HCoV-229E HCoV-NL63 homologous Human human coronavirus human coronavirus 229E infected cells involved N-terminal domain NL63 nucleic acid nucleocapsid protein nucleus oligomerization other coronaviruses pathogen Protein respiratory tract responsible reveal SARS-CoV severity subcellular localization the N protein transfected cells unique viral replication [DOI] 10.1371/journal.pone.0117833 PMC 바로가기 [Article Type] Research Article
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisResearch Article Published on 2014-08-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus attenuation was reduced yeast [DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
Inhibitory Effect of Resveratrol against Duck Enteritis Virus In VitroResearch Article Published on 2013-06-112022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addition age Cell Concentration contagious disease dose-dependent manner duck early stage Effect Enteritis exhibit expression fibroblast found host cells immunofluorescence assay impacted in vitro inactivation Infected Infection inhibit inhibitory activity Mortality nucleus plant Post-infection Protein Replication responsible resveratrol supported suppressed ultrastructure Viral protein virus virus multiplication virus nucleic acid virus replication [DOI] 10.1371/journal.pone.0065213 PMC 바로가기 [Article Type] Research Article
Suppression of Coronavirus Replication by Cyclophilin InhibitorsReview Published on 2013-05-222022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activated T cell activities acute respiratory syndrome bind block bronchitis cellular chaperone coronavirus Coronavirus replication Coronaviruses cyclophilin cyclosporin A cytokine cytosol described different disease Diseases Effect effective genes encoding hepatitis C virus Human immunodeficiency virus humans immunosuppressive include infect infectious inhibit inhibitor mammalian mice molecular mechanism mouse hepatitis NF-AT NO nuclear nucleus phosphatase physiological function Replication reported SARS-coronavirus suppression Transcription translocation Treatment Vaccine variety vesicular stomatitis virus viral replication virus viruses [DOI] 10.3390/v5051250 PMC 바로가기 [Article Type] Review
Only One Isoform of Drosophila melanogaster CTP Synthase Forms the CytoophidiumDrosophila melanogaster CTP Synthase의 단 하나의 Isoform이 Cytoophidium을 형성합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition ATP ATP synthase Author Bacteria biogenesis biological processe biological processes block Cell cell types cells conserved cytoplasm demonstrated different disrupt disrupting dissect distribution DNA and RNA domain Drosophila Drosophila melanogaster ectopic expression embryos energy metabolism enzyme example expression expression profiles form growth human cells identify independent induce isoform locus metabolism Mitochondria mutants Mutation nucleotide nucleotides nucleus organism overexpression provide shown Structure subcellular distribution subcellular structure Synthase synthase gene transcript while yeast [DOI] 10.1371/journal.pgen.1003256 PMC 바로가기 [Article Type] Research Article
Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expressionResearch Published on 2013-01-192022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated addition BCL-2 cause Cell cell cycle progression cells E protein Effect Endoplasmic reticulum epidemic diarrhea ER stress Express expressing expression function growth had no IEC IL-8 intestinal epithelial cell investigated NF-Κb NF-κB nucleus pathogen PEDV previous study Research responsible Result Stress subcellular localization survival the cell up-regulate virus [DOI] 10.1186/1743-422X-10-26 PMC 바로가기 [Article Type] Research