Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors Research Published on 2021-05-012022-10-05 Journal: Nature biomedical engineering [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Antigen complex coronavirus disease Coronavirus-2 COVID-19 detect fluids fluorescent fusion protein high-density human saliva maintain MERS MERS-CoV Middle East nanobody Nasopharyngeal swab pandemic point-of-care Polymer Protein quantification Rapid respiratory syndrome coronavirus robust Saliva SARS-CoV-2 sensitivity serum specific antigen specificity Spike proteins viral loads widespread [DOI] 10.1038/s41551-021-00734-9 [Article Type] Research
The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19)무기다인산의 치료 가능성: 코로나바이러스(COVID-19)를 제어하는 다목적 생리학적 고분자Review Published on 2021-04-152022-09-10 Journal: Theranostics [Category] MERS, SARS, 신약개발, 치료제, [키워드] ACE2 receptor addition airway airway epithelia airways alkaline phosphatase anhydride attachment binding cationic cause caused ciliary Combination coronavirus disease Course COVID-19 damages drug therapy epithelial epithelial cell epithelial cells form Gene Expression glycoprotein help hydrolysis IMPROVE Inhaled initial life cycle metabolic energy molecule MUC1 MUC5AC mucin multiorgan failure Nanoparticles Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Particle phosphatase phosphate physiological Polymer polyp polyphosphate Prevent rationale Research residues SARS-CoV-2 significantly subsequent Support target cells the disease the RBD therapeutic potential therapy transported viral receptor-binding domain virus Virus life cycle [DOI] 10.7150/thno.59535 PMC 바로가기 [Article Type] Review
Polymer-based nano-therapies to combat COVID-19 related respiratory injury: progress, prospects, and challengesReview Article Published on 2021-04-142023-06-15 Journal: Journal of Biomaterials Science. Polymer Edition [Category] MERS, SARS, [키워드] ARDS COVID-19 hydrogel nanocarrier Polymer respiratory injury Scaffold tissue engineering [DOI] 10.1080/09205063.2021.1909412 PMC 바로가기 [Article Type] Review Article
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNAArticle Published on 2021-03-292022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] binding Computational models contribute Critical domain flexible full-length Interaction Intrinsically disordered proteins macroscopic molecular motifs N protein occur offer Polymer predict Protein provide Region responsible RNA SARS-CoV-2 nucleocapsid single-genome Single-molecule biophysics underlie viral genome [DOI] 10.1038/s41467-021-21953-3 PMC 바로가기 [Article Type] Article
Self-injectable extended release formulation of Remdesivir (SelfExRem): A potential formulation alternative for COVID-19 treatment렘데시비르(SelfExRem)의 자가 주사 가능한 연장 방출 제형: COVID-19 치료를 위한 잠재적 제형 대안Article Published on 2021-03-152022-08-31 Journal: International journal of pharmaceutics [Category] MERS, SARS, 신약개발, 진단, 치료법, 치료제, [키워드] administer analyzed approach approval autoinjector benefit biodegradable polymer Care carried Concentration coronavirus Coronavirus 2019 COVID-19 COVID-19 patients COVID19 drug Drug administration effective evaluated face-to-face contact FDA food force Frequency globe Health Health care help Hospitalization In situ depot formulations indicated injection Intravenous injection Intravenous remdesivir Long-acting injectables low molecular weight mass vaccination pandemic Patient phosphate phosphate buffer PLGA Polymer provided RDV receiving reducing Remdesivir required Research SARS-CoV2 subcutaneous injection therapeutic Treatment treatment of COVID-19 tween vaccination w/v [DOI] 10.1016/j.ijpharm.2021.120329 PMC 바로가기 [Article Type] Article
Biomaterials-based formulations and surfaces to combat viral infectious diseasesReviews Published on 2021-03-092022-10-28 Journal: APL Bioengineering [Category] COVID-19, [키워드] acute respiratory syndrome Antiviral antiviral properties approach biomaterial clinical trial contagious coronavirus drug Ebola effective herbal medicine hydrophobic immunomodulatory inhibit introduced Modification molecular novel antiviral drug offer platform Polymer Prevent public health recognize reduce Research risk Safe SARS-CoV-2 translation Vaccine viral infection viral infections viral infectious disease Viral load virus virus replication viruses Zika [DOI] 10.1063/5.0029486 PMC 바로가기 [Article Type] Reviews
Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers자가 소독 음이온 폴리머에 대한 SARS-CoV-2 및 인간 코로나바이러스의 신속하고 반복적인 비활성화Communication Published on 2021-03-082022-09-10 Journal: Advanced Science [Category] MERS, SARS, 변종, 치료기술, [키워드] anionic antiviral materials application charged block polymers complications Contact contact with contaminated surfaces coronavirus COVID‐19 demonstrated Detection limit detrimental develop disease effective vaccine Effective vaccines equipment Health human coronavirus Infection mechanism microphase‐ordered materials minutes mutant virus pandemic pathogenic coronavirus pathogenic coronaviruses polyanions Polymer polymers Prevent Rapid SARS‐CoV‐2 SARS‐CoV‐2 virus Strains sulfonated thermoplastic elastomers Transmission water while [DOI] 10.1002/advs.202003503 PMC 바로가기 [Article Type] Communication
Proof of Concept for a Quick and Highly Sensitive On-Site Detection of SARS-CoV-2 by Plasmonic Optical Fibers and Molecularly Imprinted Polymers플라즈몬 광섬유 및 분자 각인 폴리머에 의한 SARS-CoV-2의 빠르고 고감도 현장 탐지를 위한 개념 증명Article Published on 2021-03-012022-09-10 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus Analysis caused chain Chain Reaction concept coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated detection diagnostic diagnostics Effectiveness equipment fiber international public health layer medium MIP molecularly imprinted polymers (MIPs) NaCl nasopharyngeal optical Optical fiber optical fiber sensors optical-chemical sensors pandemic pathogen performed physiological solution point-of-care Polymer polymerase chain reaction proof proof of concept Protein reaction reagent reagents real time receptor respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virions SARS-CoV-2 virus sensitive sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein Spread subunit surface plasmon resonance (SPR) Swab tested the SARS-CoV-2 the SARS-CoV-2 virus Transport transport medium Universal Transport Medium UTM virus was obtained [DOI] 10.3390/s21051681 PMC 바로가기 [Article Type] Article
A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial파키스탄에서 경증에서 중등도의 COVID-19 환자에 대한 요오드 복합체의 효과를 평가하기 위한 4중 맹검 위약 대조 무작위 시험(I-COVID-PK): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-102022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 30-Day mortality Admission age alleviation alleviation of symptom approved Arm ARMS baseline blinded Blinding calculated Care care providers Chest chest scan Chronic illness clinic clinical Clinical improvement Clinical management co-morbidities co-morbidity comparator complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patient COVID-19 adult patients Disinfection dissemination doctor Effectiveness Efficacy element enrolled evaluate excluded four group four groups Gender groups HRCT Infection information initial initial symptom initial symptoms Intention investigator investigators Iodine IRB lung involvement management guidelines Mild mild to moderate mild to moderate disease Moderate COVID-19 moderate disease morbidities National Health Service National Health Services non-pregnant females number objective outcome Pakistan participant Participants Patient patients PCR Placebo placebo-controlled Polymer positive Primary outcomes protocol radiological radiological improvement randomised randomised controlled trial Randomised trial randomization Randomized receiving recruited recruitment Registered remained reported resolved RT-PCR Sample size SARS-CoV-2 RT-PCR secondary outcome severity severity of symptom shown Standard standard care status Study protocol supplementary material Symptom symptomatic syrup the patient time Trial Version Viral viral clearance website [DOI] 10.1186/s13063-021-05081-3 PMC 바로가기 [Article Type] Letter
HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoVSARS-CoV-2 및 MERS-CoV의 고분자 억제제로서의 HTCCArticle Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity bats block Care characterization China chitosan chloride circulating Cluster Compound Coronaviridae coronavirus demonstrated Entry epithelia escaped ex vivo model HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Health Health care highly pathogenic HKU1 host cell HTCC human airway human airway epithelia human coronavirus humans in vitro infect information inhibited inhibition inhibitor Interaction life-threatening Local measure mechanism mechanism of action member MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus multiorgan failure NL63 Novel coronavirus OC43 pandemic pathogen Polymer Rapid Research respiratory respiratory infection respiratory syndrome coronavirus S protein SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome Coronavirus Spread the S protein virus virus entry viruses [DOI] 10.1128/JVI.01622-20 PMC 바로가기 [Article Type] Article