Low dose lung radiotherapy for COVID-19 pneumonia: A potential treatmentMini review Published on 2021-09-012022-10-05 Journal: Respiratory medicine [Category] SARS, 치료법, [키워드] acute respiratory syndrome affecting Anti-inflammatory Care country COVID-19 COVID-19 pneumonia cytokine detrimental dose Health immunomodulatory effect Inflammation low dose Low dose radiation therapy lung Lung fibrosis macrophages Most patient occur pandemic Potential treatment Radiotherapy reduce Respiratory disease risk SARS-CoV-2 pneumonia severely ill patients Side effect systemic inflammatory response therapy [DOI] 10.1016/j.rmed.2021.106531 [Article Type] Mini review
Screening of Chloroquine, Hydroxychloroquine and its derivatives for their binding affinity to multiple SARS-CoV-2 protein drug targets클로로퀸, 하이드 록시 클로로 퀴인 및 다중 SARS-COV-2 단백질 약물 표적에 대한 결합 친화력에 대한 유도체의 스크리닝Article Published on 2021-09-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] active site binding binding affinity Chloroquine Chloroquine derivatives clinician conducted COVID-19 COVID-19 pandemic derivative derivatives disrupting drug target Efficacy enzyme Enzymes Health authority Hydroxychloroquine implicated in silico approaches Infection inhibit mechanism of action molecular docking multiplication non-structural protein non-structural proteins Pathogenesis pathogenesis of SARS-CoV-2 Potential treatment Protein Proteins remodeling Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 replication SARS-CoV-2 viral Screening selected targets therapeutic potential Viral Viral protein Viral proteins was performed [DOI] 10.1080/07391102.2020.1782265 PMC 바로가기 [Article Type] Article
Combined intravenous immunoglobulin and baricitinib treatment for severe COVID-19 with rhabdomyolysis: A case report횡문근 융해증을 동반한 중증 COVID-19에 대한 정맥 면역글로불린 및 바리시티닙 병용 치료: 증례 보고Case Reports Published on 2021-09-012022-09-12 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory distress ARDS Asymptomatic carrier Baricitinib biochemical Biomarker Case report Clinical course Clinical improvement clinical recovery Combined combined use coronavirus disease correlated correlation COVID-19 creatine creatine kinase Cytokines disease severity Effects elevated Evidence female High dose Hydroxychloroquine Hypogammaglobulinemia Inflammatory biomarker inflammatory biomarkers Injury Intensive Intravenous immunoglobulin intubation IVIG IVIg. Laboratory laboratory biomarker lactate dehydrogenase Lymphocytes lymphopenia mechanical ventilation multiple organ complication neurological deficits Numerous outbreak outcome Patient patients with COVID-19 Platelets Potential treatment prognostic progressed Radiographic reflected serum severe COVID-19 severity of COVID-19 shown Spread syndrome therapy Treatment Treatment response [DOI] 10.1016/j.jfma.2021.03.014 PMC 바로가기 [Article Type] Case Reports
Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 InfectionHCN-2 세포의 전사체 분석은 SARS-CoV-2 감염 후 산화 스트레스, 노화 및 신경 세포 사멸 간의 연관성을 시사합니다Article Published on 2021-08-252022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis antioxidant Apoptosis blocking caspase caspase 3 CDK4 CDK6 CDKN2A Cell cell cycle cells cortical cell death decrease deregulation evaluate the effect explain followed by functions HCN-2 impairment increase in indicated KAT5 mechanism nervous system Neurological symptom Neurological symptoms Neuron neuronal neurons outcome oxidative stress pediatric PMAIP1 Potential treatment potential treatments Prevent PROTECT r death reduction reported required resulting ROS homeostasis SARS-CoV-2 SARS-COV-2 infection senescence SOD1 supported the cell Transcriptome transcriptomic analysis TXN upregulation virus western blot Western blot analysis [DOI] 10.3390/cells10092189 PMC 바로가기 [Article Type] Article
An Analysis Based on Molecular Docking and Molecular Dynamics Simulation Study of Bromelain as Anti-SARS-CoV-2 VariantsPharmacology Published on 2021-08-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] antiviral activity antiviral property approaches approved bind binding binding affinity binding site Bromelain changes in complex complexes COVID-19 destabilized Dynamics enzyme exhibited hACE2 human Angiotensin-converting enzyme in vitro in vivo increases in indicated inhibitor inhibitory effect Interaction molecular molecular docking Molecular dynamics simulation Mutation mutations new SARS-CoV-2 new virus Novel coronavirus potential mechanism Potential treatment Prevent Protein RBD RBD protein RBD proteins RBD variant Receptor-binding domain remained required Research resulting RMSD SARS-CoV-2 SARS-CoV-2 variants shown Simulation Spread stability the receptor-binding domain the SARS-CoV-2 treat Treatment variant variants viral spike protein virus while [DOI] 10.3389/fphar.2021.717757 PMC 바로가기 [Article Type] Pharmacology
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance프로테옴 전반에 걸친 유전자 조사는 임상 관련성이 있는 여러 SARS-CoV-2 악용 숙주 표적을 식별합니다.Research Article Published on 2021-08-172022-09-10 Journal: eLife [Category] MERS, SARS, 유전자 메커니즘, [키워드] ABO Accepted Affect affecting age Alpha Analysis Antiviral Apoptosis applied approach arising association Author cause CD209 clinical trial contribute COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 phenotypes datasets DC-SIGN death Demographic factors demonstrated disease severity evade explain Factor Factors funding Gender gene expression level gene mutation Genetic genetic colocalization genetic profile healthy individuals help Host host cells host protein host proteins Human identify identifying IL-6R immune immune response individual individuals infect Infection interact Interaction involved Karim MAK mechanism Medical Research Council mendelian randomization minor symptom minor symptoms molecular mutate natural experiment new strain no symptom no symptoms OAS1 open Open Access opens Patient patients with COVID-19 pleiotropic Potential treatment precursor predict predicted Probability PROTECT Protein Proteins proteome provide randomisation reaction receptor receptor protein reduce Research response responsible risk SARS-CoV-2 severe COVID-19 severity of COVID-19 SIGN Spike protein Strains submission susceptibility susceptible susceptible hosts Symptoms target targets the spike protein the strongest Therapeutics treat Treatment Trigger unique unit variety virus virus strains viruses Wellcome Trust with COVID-19 [DOI] 10.7554/eLife.69719 PMC 바로가기 [Article Type] Research Article
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 ReplicationBrief Report Published on 2021-08-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Antiviral Antiviral agents Antiviral assays block caused COVID-19 demonstrated derivative disease enzyme inhibit SARS-CoV-2 inhibitor molecular target non-nucleotide inhibitor pandemic of COVID-19 polymerase Potential treatment RdRP Replication RNA RNA-dependent RNA polymerase SAR-CoV-2 SARS-CoV-2 significantly targets Viral RNA [DOI] 10.3390/v13081585 PMC 바로가기 [Article Type] Brief Report
Neuroimmunology and Novel Methods of Treatment for Acute Transverse MyelitisNeurology Published on 2021-08-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute transverse myelitis addition age ATM Biomarker blocker Cell clinical trial defined described Diagnostic Criteria etiology fampridine highlight immunomodulatory therapy immunopathology Immunosuppressive agents Inflammatory response Injury Myelitis Neuroimmunology neurologic novel outcome pathophysiology plasma exchange therapy Potassium Potential treatment Radiographic Research restricted progenitor cells therapeutic Transverse Treatment [DOI] 10.7759/cureus.17043 PMC 바로가기 [Article Type] Neurology
Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin ConditionsOriginal Research Reports Published on 2021-08-012022-10-28 Journal: Stem cells and development [Category] COVID-19, MERS, SARS, [키워드] addition approach Calu-3 calu-3 cells chronic inflammation Comorbidity Concentration condition contribute contributed contributing to correlation COVID-19 COVID-19 patient Cytokine storm Diabetes Mellitus disease DM downregulation effort epithelial cell examined extracellular vesicle Extracellular vesicles Factor function Glucose human lung Jelly Meta-analysis Mortality MSCs NF-κB nuclear Organ failure outcome p65 Patient patients with COVID-19 Potential treatment RD reaction reduce renal Research SARS-CoV SARS-CoV-2 severe symptom severity of COVID-19 significant decrease STEM stem cell suggested systematic review the cytokine storm toxin toxins uremic viral infection was increased [DOI] 10.1089/scd.2021.0065 PMC 바로가기 [Article Type] Original Research Reports
TRP channels in COVID-19 disease: Potential targets for prevention and treatmentReview article Published on 2021-08-012022-10-05 Journal: Chemico-biological interactions [Category] 치료법, [키워드] acute respiratory syndrome Ageusia angiotensin-converting enzyme 2 Anosmia antibodies caused Compound coronavirus Coronavirus disease 2019 cough COVID-19 COVID-19 disease desensitization Effectiveness expressed Fever Health highlight Inflammation literature mechanism Neurological complication Pain Patient Pneumonia Potential Potential treatment prevention problems protease Protein provide SARS-CoV-2 serine 2 small molecule Symptom Symptoms target Treatment TRP TRP channels various tissue [DOI] 10.1016/j.cbi.2021.109567 [Article Type] Review article